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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
13747
World Ranking
14273
National Ranking
348

Overview

Leon G.J. Tertoolen is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, their work delves into specialized subfields including Cardiology and Cardiovascular Medicine, Molecular Biology, Surgery, Cellular and Molecular Neuroscience, and Hematology.

The scientist's main topics of study cover a range of biomedical and clinical interests. These include:

  • Cardiac electrophysiology and arrhythmias
  • Tissue Engineering and Regenerative Medicine
  • Pluripotent Stem Cells Research
  • Neuroscience and Neural Engineering
  • Cardiovascular Effects of Exercise
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Acute Myeloid Leukemia Research

Leon G.J. Tertoolen has made contributions to several peer-reviewed journals. The frequent publication venues where their work appears are:

  • Cell stem cell
  • Proceedings of the National Academy of Sciences
  • Journal of Molecular and Cellular Cardiology
  • Toxicological Sciences
  • Stem Cell Reports

They have authored and co-authored multiple research papers, some notable recent publications include:

  • "Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease" (2020, Cell stem cell)
  • "Uncoupling DNA damage from chromatin damage to detoxify doxorubicin" (2020, Proceedings of the National Academy of Sciences)
  • "A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness" (2020, Journal of Molecular and Cellular Cardiology)
  • "Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes" (2020, Toxicological Sciences)
  • "Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias" (2020, Stem Cell Reports)

Their research has involved collaboration with several frequent co-authors, including:

  • Christine L. Mummery
  • Berend J. van Meer
  • Elisa Giacomelli
  • Ana Krotenberg García
  • Richard P. Davis

Best Publications

  • Differentiation of human embryonic stem cells to cardiomyocytes

    Christine Lindsay Mummery;Petrus Adrianus Frederik Maria Doevendans;Leon Gerardus Joseph Tertoolen

  • FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

    Armando van der Horst;Leon G.J. Tertoolen;Lydia M.M. de Vries-Smits;Roy A. Frye

  • Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH.

    W. H. Moolenaar;L. G. J. Tertoolen;S. W. de Laat

  • Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

    W H Moolenaar;L G Tertoolen;S W de Laat

  • Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction.

    Linda W. van Laake;Robert Passier;Jantine Monshouwer-Kloots;Arie J. Verkleij

  • Small molecule absorption by PDMS in the context of drug response bioassays

    B.J. van Meer;H. de Vries;K.S.A. Firth;J. van Weerd

  • Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.

    Stefan R. Braam;Leon Tertoolen;Anja van de Stolpe;Thomas Meyer

  • Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

    Elisa Giacomelli;Viviana Meraviglia;Giulia Campostrini;Amy Cochrane

  • The epidermal growth factor-induced calcium signal in A431 cells.

    W. H. Moolenaar;R. J. Aerts;L. G. J. Tertoolen;S. W. De Laat

  • Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

    Malkel P. Peppelenbosch;Leon G.J. Tertoolen;Willem J. Hage;Slegfried W. de Laat

  • Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

    J. Den Hertog;C. E. G. M. Pals;M. P. Peppelenbosch;L. G. J. Tertoolen

  • Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

    Vanesa Muncan;Owen J. Sansom;Leon Tertoolen;Toby Phesse

  • Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.

    Elisa Giacomelli;Milena Bellin;Luca Sala;Berend J. van Meer

  • MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

    Luca Sala;Berend J. Van Meer;Leon G.J. Tertoolen;Jeroen Bakkers

  • Rac mediates growth factor-induced arachidonic acid release

    Maikel P Peppelenbosch;Rong-Guo Qiu;Alicia M.M de Vries-Smits;Leon G.J Tertoolen

  • Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors.

    L H K Defize;J Boonstra;J Meisenhelder;W Kruijer

  • Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

    Maikel P. Peppelenbosch;Leon G.J. Tertoolen;Jeroen den Hertog;Siegfried W. de Laat

  • Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.

    Marcelo C. Ribeiro;Leon G. Tertoolen;Juan A. Guadix;Milena Bellin

  • Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long‐QT syndrome

    Milena Bellin;Simona Casini;Richard P. Davis;Cristina D'Aniello

  • FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the

    Armando van der Horst;Leon G. J. Tertoolen;Roy A. Frye;Boudewijn M. T. Burgering

Frequent Co-Authors

Christine L. Mummery
Christine L. Mummery Leiden University Medical Center
S. W. De Laat
S. W. De Laat Utrecht University
Robert Passier
Robert Passier University of Twente
Maikel P. Peppelenbosch
Maikel P. Peppelenbosch Erasmus University Rotterdam
Wouter H. Moolenaar
Wouter H. Moolenaar Antoni van Leeuwenhoek Hospital
Johannes Boonstra
Johannes Boonstra Utrecht University
Jeroen den Hertog
Jeroen den Hertog Hubrecht Institute for Developmental Biology and Stem Cell Research
Chris Denning
Chris Denning University of Nottingham
Godfrey L. Smith
Godfrey L. Smith University of Glasgow
Thomas Eschenhagen
Thomas Eschenhagen Universität Hamburg

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