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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
8782
World Ranking
16786
National Ranking
1323

Overview

Chris Denning is affiliated with the University of Nottingham in the United Kingdom. Their research spans multiple fields, primarily focusing on medicine and biochemistry, genetics, and molecular biology. Within these broad fields, they have contributed extensively to subfields such as molecular biology, cardiology and cardiovascular medicine, clinical psychology, biomedical engineering, and infectious diseases.

Denning's research topics cover a diverse range of subjects. Major themes include COVID-19 and mental health, pluripotent stem cells research, neuroscience and neural engineering, tissue engineering and regenerative medicine, 3D printing in biomedical research, SARS-CoV-2 detection and testing, as well as cardiomyopathy and myosin studies.

Recent significant publications by Denning and collaborators include:

  • Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease (2021, Journal of the American Heart Association)
  • Students' Views towards Sars-Cov-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021, International Journal of Environmental Research and Public Health)
  • Impacts of the COVID-19 Pandemic and Self-Isolation on Students and Staff in Higher Education: A Qualitative Study (2021, International Journal of Environmental Research and Public Health)
  • Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format (2020, Stem Cell Reports)
  • Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes (2020, Toxicological Sciences)

Denning frequently publishes in several academic venues, among which the following stand out for their volume of publications:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Environmental Research and Public Health
  • Stem Cell Reports
  • F1000Research
  • Journal of Molecular and Cellular Cardiology

The scientist also collaborates regularly with a group of frequent co-authors, including Holly Blake, Jessica Corner, Jonathan K. Ball, Katja Gehmlich, and Nguyen T.N. Vo. Their collaborations reflect a network spanning expertise in related biomedical and clinical research areas.

Best Publications

  • Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

    Katherine Amps;Peter W. Andrews;George Anyfantis;Lyle Armstrong

  • Small molecule absorption by PDMS in the context of drug response bioassays

    B.J. van Meer;H. de Vries;K.S.A. Firth;J. van Weerd

  • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

    Elena Matsa;Divya Rajamohan;Emily Dick;Lorraine Young

  • Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep.

    C Denning;S Burl;A Ainslie;J Bracken

  • Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V-96 Plate Aggregation System Highlights Interline Variability

    Paul W. Burridge;David Anderson;Helen Priddle;Maria D. Barbadillo Muñoz

  • Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

    Chris Denning;Viola Borgdorff;James Crutchley;Karl S.A. Firth

  • MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

    Luca Sala;Berend J. Van Meer;Leon G.J. Tertoolen;Jeroen Bakkers

  • Transgenic Enrichment of Cardiomyocytes From Human Embryonic Stem Cells

    David Anderson;Tim Self;Ian R Mellor;Gareth Goh

  • CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

    Diogo Mosqueira;Ingra Mannhardt;Jamie R Bhagwan;Katarzyna Lis-Slimak

  • Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome

    Cinzia Allegrucci;Yue Zhong Wu;Alexandra Thurston;Chris N. Denning

  • Automated, scalable culture of human embryonic stem cells in feeder‐free conditions

    Robert James Thomas;David Anderson;Amit Chandra;Nigel M. Smith

  • Materials for stem cell factories of the future

    Adam Celiz;James G W Smith;Robert Samuel M Langer;Daniel G Anderson

  • N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

    Abdulkadir Abakir;Tom C. Giles;Agnese Cristini;Jeremy M. Foster

  • Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

    Elena Matsa;James E. Dixon;Christopher Medway;Orestis Georgiou

  • Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.

    Caitlin Hall;Katja Gehmlich;Katja Gehmlich;Chris Denning;Davor Pavlovic

  • Improved genetic manipulation of human embryonic stem cells

    Stefan R Braam;Chris Denning;Stieneke van den Brink;Peter Kats

  • Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening

    Emily Dick;Divya Rajamohan;Jonathon Ronksley;Chris Denning

  • Bystander Effects of Different Enzyme-Prodrug Systems for Cancer Gene Therapy Depend on Different Pathways for Intercellular Transfer of Toxic Metabolites, a Factor That Will Govern Clinical Choice of Appropriate Regimes

    C. Denning;J. D. Pitts

  • Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy.

    Bo Lin;Yang Li;Lu Han;Aaron D. Kaplan

  • Current status of drug screening and disease modelling in human pluripotent stem cells

    Divya Rajamohan;Elena Matsa;Spandan Kalra;James Crutchley

Frequent Co-Authors

Christine L. Mummery
Christine L. Mummery Leiden University Medical Center
Morgan R. Alexander
Morgan R. Alexander University of Nottingham
Thomas Eschenhagen
Thomas Eschenhagen Universität Hamburg
Martyn C. Davies
Martyn C. Davies University of Nottingham
Robert Passier
Robert Passier University of Twente
Leon G.J. Tertoolen
Leon G.J. Tertoolen Leiden University Medical Center
Godfrey L. Smith
Godfrey L. Smith University of Glasgow
David A. Barrett
David A. Barrett University of Nottingham

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