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Biology and Biochemistry

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57
Citations
11276
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13876
National Ranking
5866

Overview

Leslie V. Parise is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Immunology and Allergy, Hematology, Cardiology and Cardiovascular Medicine, and Genetics.

Their scholarly work addresses several main topics, including:

  • Cell Adhesion Molecules Research
  • Ubiquitin and proteasome pathways
  • Platelet Disorders and Treatments
  • Cancer-related gene regulation
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Blood properties and coagulation
  • Hippo pathway signaling and YAP/TAZ

Recent publications by Parise and collaborators include:

  • "Discovery and Development of Cyclic Peptide Inhibitors of CIB1" (2021) published in ACS Medicinal Chemistry Letters
  • "Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1" (2020) published in ACS Chemical Biology
  • "Identification of a Novel Calcium-binding Protein That Interacts with the Integrin α IIb Cytoplasmic Domain" (2021) published in UNC Libraries
  • "CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer" (2020) published in UNC Libraries
  • "CIB1: a small protein with big ambitions" (2024) published in UNC Libraries

Parise frequently publishes in venues such as UNC Libraries, ACS Medicinal Chemistry Letters, ACS Chemical Biology, Arteriosclerosis Thrombosis and Vascular Biology, and Nature Genetics.

Collaborations are a consistent aspect of Parise's work. Frequent co-authors include:

  • Thomas Leisner
  • Stephen P. Holly
  • Justin L. Black
  • Cheryl A. Hillery
  • Victoria A. Haberman

The scope of Leslie V. Parise's research encompasses molecular mechanisms linked to cellular adhesion and signaling, particularly focusing on proteins such as CIB1 that have implications in cancer biology, cardiovascular research, and platelet function. The group's investigations explore protein interactions, signaling pathways, and the regulation of cell survival and growth within these contexts.

Best Publications

  • The platelet membrane glycoprotein IIb-IIIa complex

    D. R. Phillips;I. F. Charo;Leslie V Parise;L. A. Fitzgerald

  • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

    Patricia J. Keely;John K. Westwick;Ian P. Whitehead;Channing J. Der

  • Identification of a Novel Calcium-binding Protein That Interacts with the Integrin αIIb Cytoplasmic Domain

    Ulhas P. Naik;Pankaj M. Patel;Leslie V. Parise

  • Integrins and GTPases in tumour cell growth, motility and invasion.

    Patricia Keely;Leslie V Parise;Rudolph L Juliano

  • Regulation of vascular integrins

    S. S. Smyth;C. C. Joneckis;Leslie V Parise

  • Integrin alpha 4 beta 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia

    Christopher C. Joneckis;Rhonda L. Ackley;Eugene P. Orringer;Elizabeth A. Wayner

  • Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48

    Saima Riazuddin;Inna A Belyantseva;Arnaud P J Giese;Kwanghyuk Lee

  • Relationships between Rap1b, Affinity Modulation of Integrin αIIbβ3, and the Actin Cytoskeleton

    Alessandra Bertoni;Seiji Tadokoro;Koji Eto;Nisar Pampori

  • Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension.

    Kenneth I. Ataga;Charity G. Moore;Cheryl A. Hillery;Susan Jones

  • Multiple roles of integrins in cell motility.

    Stephen P. Holly;Mark K. Larson;Leslie V. Parise

  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion

    Patrick C. Hines;Qin Zen;Sharran N. Burney;Deborah A. Shea

  • R-Ras Signals through Specific Integrin α Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells

    Patricia J. Keely;Elena V. Rusyn;Adrienne D. Cox;Leslie V. Parise

  • Reconstitution of the purified platelet fibrinogen receptor. Fibrinogen binding properties of the glycoprotein IIb-IIIa complex.

    Leslie V Parise;D. R. Phillips

  • The α2β1 Integrin Is a Necessary Co-receptor for Collagen-induced Activation of Syk and the Subsequent Phosphorylation of Phospholipase Cγ2 in Platelets

    Patricia J. Keely;Leslie V. Parise

  • New aspects of integrin signaling in cancer

    Leslie V Parise;Jung Weon Lee;Rudolph L Juliano

  • Biologically Active CD40 Ligand Is Elevated in Sickle Cell Anemia: Potential Role for Platelet-Mediated Inflammation

    Sheritha P. Lee;Kenneth I. Ataga;Eugene P. Orringer;David R. Phillips

  • Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.

    Leslie V Parise;S. L. Helgerson;B. Steiner;L. Nannizzi

  • Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution.

    P. J. Newman;C. A. Hillery;R. Albrecht;Leslie V Parise

  • Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-αvβ3 interactions

    Rahima Zennadi;Patrick C. Hines;Patrick C. Hines;Patrick C. Hines;Laura M. De Castro;Laura M. De Castro;Laura M. De Castro;Jean Pierre Cartron;Jean Pierre Cartron;Jean Pierre Cartron

  • Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.

    Holly R. Gentry;Alex U. Singer;Laurie Betts;Cheng Yang

Frequent Co-Authors

Laurent Abel
Laurent Abel Université Paris Cité
Andrew S. Weyrich
Andrew S. Weyrich University of Utah
Emmanuelle Jouanguy
Emmanuelle Jouanguy Necker-Enfants Malades Hospital
Adrienne D. Cox
Adrienne D. Cox University of North Carolina at Chapel Hill
Xian Chen
Xian Chen University of North Carolina at Chapel Hill
Sherry Niessen
Sherry Niessen Pfizer (United States)
John Sondek
John Sondek University of North Carolina at Chapel Hill
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Zubair M. Ahmed
Zubair M. Ahmed University of Maryland, Baltimore
Sheikh Riazuddin
Sheikh Riazuddin University of Health Sciences Lahore

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