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Molecular Biology

D-Index
77
Citations
21819
World Ranking
1111
National Ranking
574

Overview

Adrienne D. Cox is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions also made to Molecular Biology, Oncology, Cell Biology, Pathology and Forensic Medicine, and Epidemiology.

Their work covers multiple main topics including:

  • Protein Kinase Regulation and GTPase Signaling
  • Melanoma and MAPK Pathways
  • Pancreatic and Hepatic Oncology Research
  • PI3K/AKT/mTOR signaling in cancer
  • Autophagy in Disease and Therapy
  • Cancer Mechanisms and Therapy
  • Peptidase Inhibition and Analysis

Adrienne D. Cox has published extensively in a range of scientific journals. Frequent publication venues include:

  • UNC Libraries
  • Cancer Research
  • Molecular Cancer Research
  • Science
  • Cell Reports

Recent papers provide insight into their research focus and collaboration. Notable recent publications include:

  • "Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer" (2022, Cancer Research)
  • "Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers" (2020, Cell Reports)
  • "Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers" (2024, Science)
  • "TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors" (2023, Cancer Research)
  • "Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer" (2024, Science)

The scientist has frequently collaborated with a select group of coauthors, including:

  • Channing J. Der
  • Clint A. Stalnecker
  • Kirsten L. Bryant
  • Andrew M. Waters
  • Mariaelena Pierobon

Best Publications

  • Drugging the undruggable Ras: mission possible?

    Adrienne D. Cox;Stephen W. Fesik;Alec C. Kimmelman;Ji Luo

  • Ras history: The saga continues.

    Adrienne D. Cox;Channing J. Der

  • Ras signalling on the endoplasmic reticulum and the Golgi.

    Vi K. Chiu;Trever Bivona;Angela Hach;J. Bernard Sajous

  • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

    Kiyoko Kato;Adrienne D. Cox;Adrienne D. Cox;Mark M. Hisaka;Mark M. Hisaka;Suzanne M. Graham;Suzanne M. Graham

  • The dark side of Ras: regulation of apoptosis

    Adrienne D Cox;Channing J Der

  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

    Kirsten L. Bryant;Clint A. Stalnecker;Daniel Zeitouni;Jennifer E. Klomp

  • PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

    Trever G. Bivona;Steven E. Quatela;Brian O. Bodemann;Ian M. Ahearn

  • Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

    Trever G. Bivona;Ignacio Pérez de Castro;Ian M. Ahearn;Theresa M. Grana

  • Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.

    H Plutner;A D Cox;S Pind;R Khosravi-Far

  • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

    Edwina C. Lerner;Yimin Qian;Michelle A. Blaskovich;Renae D. Fossum

  • Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

    Brian C. Capell;Michael R. Erdos;James P. Madigan;James J. Fiordalisi

  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells

    Kian Huat Lim;Antonio T. Baines;James J. Fiordalisi;Michail Shipitsin

  • Rho Family GTPase Modification and Dependence on CAAX Motif-signaled Posttranslational Modification

    Patrick J. Roberts;Natalia Mitin;Patricia J. Keller;Emily J. Chenette

  • RALA and RALBP1 regulate mitochondrial fission at mitosis

    David F. Kashatus;Kian Huat Lim;Kian Huat Lim;Donita C. Brady;Donita C. Brady;Nicole L.K. Pershing

  • Farnesyltransferase inhibitors and cancer treatment: Targeting simply ras?

    Adrienne D Cox;Channing J Der

  • Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

    Adrienne D. Cox;Channing J. Der;Mark R. Philips

  • Protein prenylation: more than just glue?

    Adrienne D. Cox;Channing J. Der

  • Biological assays for Ras transformation.

    Geoffrey J. Clark;Adrienne D. Cox;Suzanne M. Graham;Channing J. Der

  • PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.

    James J. Fiordalisi;Patricia J. Keller;Adrienne D. Cox

  • L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases.

    J. M. Rhoads;R. A. Argenzio;W. Chen;R. A. Rippe

Frequent Co-Authors

Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Lee M. Graves
Lee M. Graves University of North Carolina at Chapel Hill
Mark R. Philips
Mark R. Philips New York University
Yoel Kloog
Yoel Kloog Tel Aviv University
Emanuel F. Petricoin
Emanuel F. Petricoin George Mason University
Otto Zhou
Otto Zhou University of North Carolina at Chapel Hill
Roya Khosravi-Far
Roya Khosravi-Far Beth Israel Deaconess Medical Center
Agnieszka K. Witkiewicz
Agnieszka K. Witkiewicz Roswell Park Cancer Institute
Sharon L. Campbell
Sharon L. Campbell University of North Carolina at Chapel Hill
John Westwick
John Westwick Novartis (Switzerland)

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