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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
21830
World Ranking
4105
National Ranking
80

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

John Westwick is affiliated with Novartis in Switzerland and has a research focus bridging biochemistry, genetics, molecular biology, and medicine. Their body of work encompasses significant contributions within molecular biology, immunology, oncology, genetics, and pathology and forensic medicine.

The scientist's research topics include:

  • Protein Kinase Regulation and GTPase Signaling
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Cell Adhesion Molecules Research
  • Melanoma and MAPK Pathways
  • Cancer-related Molecular Pathways

John Westwick has published extensively, with numerous papers appearing in venues such as UNC Libraries, Cancer Research, The Journal of Immunology, JCI Insight, and Cancer Immunology Research. Key recent publications include:

  • "Ceramide Activates the Stress-activated Protein Kinases," 2021, UNC Libraries
  • "Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy," 2021, The Journal of Immunology
  • "A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy," 2022, JCI Insight
  • "Oncogenic ras induces gastrin gene expression in colon cancer," 2021, UNC Libraries
  • "Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-B-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation," 2021, UNC Libraries

Their frequent collaborators include:

  • Channing J. Der
  • Eric Lazear
  • Alexander S. Krupnick
  • Anirban Banerjee
  • Dongge Li

John Westwick's publications primarily center on biochemistry, genetics, and molecular biology with a narrower focus on molecular biology. Additional emphasis is placed on immunology and oncology, reflecting a cross-disciplinary engagement with cancer biology and immune mechanisms.

Overall, the author's research intersects molecular signaling pathways and immune system functions relevant to cancer biology and therapeutic approaches such as immunotherapy and CAR-T cell therapy.

Best Publications

  • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

    Patricia J. Keely;John K. Westwick;Ian P. Whitehead;Channing J. Der

  • Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung.

    T J Standiford;S L Kunkel;M A Basha;S W Chensue

  • IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

    David J. Jackson;David J. Jackson;Heidi Makrinioti;Batika M. J. Rana;Betty W. H. Shamji

  • Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.

    J K Westwick;Q T Lambert;G J Clark;M Symons

  • Chemokines and T lymphocytes: more than an attraction.

    Stephen G Ward;Kevin Bacon;John Westwick

  • Ceramide Activates the Stress-activated Protein Kinases

    John K. Westwick;Alicja E. Bielawska;Ghassan Dbaibo;Yusuf A. Hannun

  • Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

    Timothy S. Finco;John K. Westwick;Jacqueline L. Norris;Amer A. Beg

  • The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

    Fabrizio Mainiero;Chiara Murgia;Chiara Murgia;Kishore K. Wary;Kishore K. Wary;Anna Maria Curatola

  • Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.

    R Khosravi-Far;M A White;J K Westwick;P A Solski

  • Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.

    John K. Westwick;Christoff Weitzel;Audrey Minden;Michael Karin

  • Lck Regulates Vav Activation of Members of the Rho Family of GTPases

    J Han;B Das;W Wei;L Van Aelst

  • Identifying off-target effects and hidden phenotypes of drugs in human cells

    Marnie MacDonald;Jane Lamerdin;Stephen Owens;Brigitte Keon

  • Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway

    David Joyce;Boumediene Bouzahzah;Maofu Fu;Chris Albanese

  • Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle

    Amel Mettouchi;Sharon Klein;Wenjun Guo;Wenjun Guo;Miguel Lopez-Lago

  • Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

    Janine Beale;Janine Beale;Janine Beale;Annabelle Jayaraman;Annabelle Jayaraman;Annabelle Jayaraman;David J. Jackson;Jonathan D. R. Macintyre

  • Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

    Brion W. Murray;Chuangxing Guo;Joseph Piraino;John K. Westwick

  • The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes

    Yannis Sotsios;Gillian C. Whittaker;John Westwick;Stephen G. Ward

  • Chemokines: understanding their role in T-lymphocyte biology

    Stephen G. Ward;John Westwick

  • IL-4 inhibits the expression of IL-8 from stimulated human monocytes.

    Theodore J. Standiford;Robert M. Strieter;Stephen W. Chensue;John Westwick

  • A Novel Murine Model of Severe Pulmonary Arterial Hypertension

    Loredana Ciuclan;Olivier Bonneau;Martin Hussey;Nicholas Duggan

Frequent Co-Authors

Stephen G. Ward
Stephen G. Ward University of Bath
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Steven L. Kunkel
Steven L. Kunkel University of Michigan–Ann Arbor
David A. Brenner
David A. Brenner University of California, San Diego
Sebastian L. Johnston
Sebastian L. Johnston Imperial College London
Barry V. L. Potter
Barry V. L. Potter University of Oxford
Robert M. Strieter
Robert M. Strieter University of Virginia
Stephen W. Michnick
Stephen W. Michnick University of Montreal
Patrick Mallia
Patrick Mallia Imperial College London
Nathan W. Bartlett
Nathan W. Bartlett Imperial College London

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