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D-Index & Metrics

Molecular Biology

D-Index
87
Citations
24861
World Ranking
805
National Ranking
426

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jonathan Chernoff is affiliated with Fox Chase Cancer Center in the United States. Their research spans multiple fields, with a focus on biochemistry, genetics, and molecular biology, as well as medicine. Subfields prominently represented in their work include molecular biology, oncology, cell biology, pulmonary and respiratory medicine, and immunology.

The scientist's main research topics cover several biological pathways and disease mechanisms. These include:

  • Ubiquitin and proteasome pathways
  • Melanoma and MAPK pathways
  • Hippo pathway signaling and YAP/TAZ
  • Protein kinase regulation and GTPase signaling
  • Cancer-related molecular pathways
  • Protein degradation and inhibitors
  • Colorectal cancer treatments and studies

Jonathan Chernoff's publication record includes research articles in various scientific journals. Notable recent papers include:

  • "RAC1 as a Therapeutic Target in Malignant Melanoma," published in 2020 in Trends in Cancer
  • "Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests," published in 2021 in PLoS ONE
  • "Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma," published in 2020 in Science Signaling
  • "Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart," published in 2022 in Frontiers in Cardiovascular Medicine
  • "Development and Utility of a PAK1-Selective Degrader," published in 2022 in Journal of Medicinal Chemistry

The scientist has collaborated frequently with several colleagues, including Cristina Uribe-Alvarez, Alexa C. Cannon, Daniela Araiza-Olivera, Kathy Q. Cai, and James S. Duncan. Publication venues where Jonathan Chernoff has contributed multiple works include Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, bioRxiv, Cancer Research, UNC Libraries, and PLoS ONE.

Jonathan Chernoff has been recognized with the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

    Shengjia Zhang;Jiahuai Han;Mary Ann Sells;Jonathan Chernoff

  • Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.

    Mary Ann Sells;Ulla G Knaus;Shubha Bagrodia;Diane M Ambrose

  • Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

    Peter Penzes;Alexander Beeser;Jonathan Chernoff;Martin R. Schiller

  • Apoptotic Phosphorylation of Histone H2B Is Mediated by Mammalian Sterile Twenty Kinase

    Wang L. Cheung;Kozo Ajiro;Kumiko Samejima;Malgorzata Kloc

  • p21-activated kinases: three more join the Pak.

    Zahara M. Jaffer;Jonathan Chernoff

  • PAK signalling during the development and progression of cancer.

    Maria Radu;Galina Semenova;Rachelle Kosoff;Rachelle Kosoff;Jonathan Chernoff

  • Identification of a Mouse p21Cdc42/Rac Activated Kinase

    Shubha Bagrodia;Stephen J. Taylor;Caretha L. Creasy;Jonathan Chernoff

  • Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

    Ulla G. Knaus;Sharron Morris;Hui-Jia Dong;Jonathan Chernoff

  • p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

    Mary Ann Sells;Jonathan T. Boyd;Jonathan Chernoff

  • Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1

    Jonathan D. Graves;Yukiko Gotoh;Yukiko Gotoh;Kevin E. Draves;Diane Ambrose

  • An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

    Sean W. Deacon;Alexander Beeser;Jami A. Fukui;Ulrike E.E. Rennefahrt

  • A tale of two Paks

    Luis E. Arias-Romero;Jonathan Chernoff

  • An in vivo assay to test blood vessel permeability.

    Maria Radu;Jonathan D. Chernoff

  • Regulation of Macropinocytosis by p21-activated Kinase-1

    Suranganie Dharmawardhane;Annette Schürmann;Mary Ann Sells;Jonathan Chernoff

  • Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

    Feng Liu;David E. Hill;Jonathan Chernoff

  • Emerging from the Pak: the p21-activated protein kinase family.

    Mary Ann Sells;Jonathan Chernoff

  • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.

    Liana Adam;Ratna Vadlamudi;Sudhir Babu Kondapaka;Jonathan Chernoff

  • The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

    M.L. Galisteo;J. Chernoff;Y.C. Su;E.Y. Skolnik

  • Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

    Juliane Bubeck Wardenburg;Rajita Pappu;Jia-Ying Bu;Bruce Mayer

  • The genetics of Pak.

    Clemens Hofmann;Mikhail Shepelev;Jonathan Chernoff

Frequent Co-Authors

Joseph R. Testa
Joseph R. Testa Fox Chase Cancer Center
D. Wade Clapp
D. Wade Clapp Indiana University
Owen J. T. McCarty
Owen J. T. McCarty Oregon Health & Science University
Erica A. Golemis
Erica A. Golemis Fox Chase Cancer Center
Gary M. Bokoch
Gary M. Bokoch Scripps Research Institute
David A. Williams
David A. Williams Boston Children's Hospital
R. John Solaro
R. John Solaro University of Illinois at Chicago
Ratna K. Vadlamudi
Ratna K. Vadlamudi The University of Texas at Austin
Jeffrey Field
Jeffrey Field University of Pennsylvania
Ulla G. Knaus
Ulla G. Knaus University College Dublin

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