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D-Index & Metrics

Biology and Biochemistry

D-Index
115
Citations
59573
World Ranking
778
National Ranking
490

Overview

Joseph Avruch is affiliated with Harvard University in the United States. Their research contributions span several interconnected fields, primarily within biochemistry, genetics, and molecular biology, along with medicine. The scientist's work covers subfields including molecular biology, cancer research, pediatrics, perinatology, child health, genetics, and aging.

Their research topics emphasize RNA modifications and cancer, cancer-related molecular mechanisms, RNA research and splicing, birth, development and health, digestive system health, genetics, aging, and longevity in model organisms, and thermoregulation and physiological responses. These areas reflect a multidisciplinary approach to understanding molecular and physiological processes.

Joseph Avruch has contributed to several recent academic papers, notable for their diversity in research focus and publication venues:

  • A MicroRNA Linking Human Positive Selection and Metabolic Disorders, 2020, Cell
  • RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression, 2021, Molecular Metabolism
  • Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage, 2022, Diabetes
  • Role of liver transplantation in acute liver failure due to exertional heat stroke, 2023, HPB

Frequent co-authors in Joseph Avruch's research include Laura Regué, Fei Ji, Ning Dai, Lifeng Wang, and Nasa Sinnott-Armstrong. This collaboration network likely supports interdisciplinary investigations and development of insights within the multiple research areas addressed.

Publication venues for Joseph Avruch's work include Cell, Molecular Metabolism, Diabetes, and HPB, each representing specialized journals in molecular biology, metabolism, endocrinology, and hepatobiliary medicine respectively.

Best Publications

  • Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

    John M. Kyriakis;Joseph Avruch

  • The stress-activated protein kinase subfamily of c-Jun kinases.

    John M. Kyriakis;Papia Banerjee;Eleni Nikolakaki;Eleni Nikolakaki;Tianang Dai

  • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

    Kenta Hara;Yoshiko Maruki;Xiaomeng Long;Ken ichi Yoshino

  • Phosphorylation of c- jun mediated by MAP kinases

    Bernd J. Pulverer;John M. Kyriakis;Joseph Avruch;Eleni Nikolakaki

  • Raf-1 activates MAP kinase-kinase.

    John M. Kyriakis;Harald App;Xian-feng Zhang;Papia Banerjee

  • Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

    Kenta Hara;Kazuyoshi Yonezawa;Qing-Ping Weng;Mark T. Kozlowski

  • Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

    John M. Kyriakis;Joseph Avruch

  • Sounding the alarm: protein kinase cascades activated by stress and inflammation.

    John M. Kyriakis;Joseph Avruch

  • Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.

    Sánchez I;Hughes Rt;Mayer Bj;Mayer Bj;Yee K

  • Rheb Binds and Regulates the mTOR Kinase

    Xiaomeng Long;Yenshou Lin;Sara Ortiz-Vega;Kazuyoshi Yonezawa

  • Yap1 acts downstream of α-catenin to control epidermal proliferation

    Karin Schlegelmilch;Morvarid Mohseni;Morvarid Mohseni;Oktay Kirak;Jan Pruszak;Jan Pruszak

  • Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.

    Xian-Feng Zhang;Jeffrey Settleman;John Kyriakis;Erika Takeuchi-Suzuki

  • Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

    Dawang Zhou;Claudius Conrad;Fan Xia;Ji Sun Park

  • Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells.

    Joseph Avruch;Donald F. Hoelzl Wallach

  • Protein kinase cascades activated by stress and inflammatory cytokines

    John M. Kyriakis;Joseph Avruch

  • Raf meets Ras: completing the framework of a signal transduction pathway

    Joseph Avruch;Xian-feng Zhang;John M. Kyriakis

  • The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

    Hiroki Nojima;Hiroki Nojima;Chiharu Tokunaga;Satoshi Eguchi;Noriko Oshiro

  • Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

    Daniel J. Price;J. Russell Grove;Victor Calvo;Joseph Avruch

  • 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

    Dario R. Alessi;Mark T. Kozlowski;Qing-Ping Weng;Nick Morrice

  • Regulation of eIF-4E BP1 Phosphorylation by mTOR

    Kenta Hara;Kazuyoshi Yonezawa;Mark T. Kozlowski;Tadanori Sugimoto

Frequent Co-Authors

John M. Kyriakis
John M. Kyriakis Tufts University
Kazuyoshi Yonezawa
Kazuyoshi Yonezawa Kobe University
Nabeel Bardeesy
Nabeel Bardeesy Harvard University
Zhijun Luo
Zhijun Luo Nanchang University
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute
Liliana Minichiello
Liliana Minichiello University of Oxford
Lee A. Witters
Lee A. Witters Dartmouth College
Joseph T. Neary
Joseph T. Neary University of Miami
Leonard I. Zon
Leonard I. Zon Harvard University
Ramnik J. Xavier
Ramnik J. Xavier Broad Institute

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