What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Phosphorylation
John M. Kyriakis spends much of his time researching Cell biology, Kinase, Mitogen-activated protein kinase, Signal transduction and Mitogen-activated protein kinase kinase.
His Cell biology research is multidisciplinary, incorporating elements of Apoptosis and Fas ligand.
His Kinase research incorporates elements of Transcription factor and Phosphorylation.
Mitogen-activated protein kinase is the subject of his research, which falls under Biochemistry.
His Signal transduction study combines topics in areas such as Ceramide, Programmed cell death, c-jun and Transactivation.
His Mitogen-activated protein kinase kinase research integrates issues from MAP2K7, Cancer research and MAP kinase kinase kinase.
His most cited work include:
- Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation (2913 citations)
- The stress-activated protein kinase subfamily of c-Jun kinases. (2395 citations)
- Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. (1660 citations)
What are the main themes of his work throughout his whole career to date?
John M. Kyriakis focuses on Cell biology, Kinase, MAP kinase kinase kinase, Signal transduction and ASK1.
His research in the fields of Mitogen-activated protein kinase and p38 mitogen-activated protein kinases overlaps with other disciplines such as RNA interference.
His study in the fields of MAPK7 under the domain of Mitogen-activated protein kinase overlaps with other disciplines such as GRB10.
John M. Kyriakis combines subjects such as Transcription factor and Phosphorylation with his study of Kinase.
As a part of the same scientific study, John M. Kyriakis usually deals with the MAP kinase kinase kinase, concentrating on Mitogen-activated protein kinase kinase and frequently concerns with MAP2K7 and Akt/PKB signaling pathway.
As part of the same scientific family, John M. Kyriakis usually focuses on Signal transduction, concentrating on Transactivation and intersecting with c-jun.
He most often published in these fields:
- Cell biology (70.45%)
- Kinase (43.18%)
- MAP kinase kinase kinase (38.64%)
What were the highlights of his more recent work (between 2006-2016)?
- Cell biology (70.45%)
- Kinase (43.18%)
- Signal transduction (31.82%)
In recent papers he was focusing on the following fields of study:
John M. Kyriakis mainly investigates Cell biology, Kinase, Signal transduction, Transcription factor and Programmed cell death.
His work on MAP kinase kinase kinase and Protein kinase A as part of general Cell biology study is frequently connected to RNA interference, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His studies deal with areas such as Mitogen-activated protein kinase and Cell signaling as well as MAP kinase kinase kinase.
His work in the fields of Kinase, such as MAPK/ERK pathway, intersects with other areas such as Hes3 signaling axis.
His study in Signal transduction is interdisciplinary in nature, drawing from both Serine, Cellular differentiation, Cell growth and Homology.
His biological study spans a wide range of topics, including Proinflammatory cytokine, Pathogen-associated molecular pattern, p38 mitogen-activated protein kinases and Innate immune system.
Between 2006 and 2016, his most popular works were:
- Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update (778 citations)
- Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (49 citations)
- Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function (46 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Cell biology, Signal transduction, Programmed cell death, RNA interference and Transcription factor.
His work on p38 mitogen-activated protein kinases is typically connected to Acquired immune system as part of general Cell biology study, connecting several disciplines of science.
John M. Kyriakis interconnects Interferon regulatory factors, Pathogen-associated molecular pattern, Pattern recognition receptor, Innate immune system and Proinflammatory cytokine in the investigation of issues within p38 mitogen-activated protein kinases.
John M. Kyriakis integrates many fields, such as Acquired immune system, MAPK/ERK pathway, Kinase, Transgene, Conditional gene knockout and Signal transducing adaptor protein, in his works.
His work carried out in the field of Caspase brings together such families of science as Golgi apparatus, Nucleus, Protein kinase A and Cell polarity.
The study incorporates disciplines such as Autophagy, ATG5, Gene knockdown, Transcriptional regulation and FOXO3 in addition to Gene silencing.
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