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Biology and Biochemistry

D-Index
104
Citations
65070
World Ranking
1226
National Ranking
726

Overview

John H. Kehrl is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields including Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these broad areas, they focus on subfields such as Immunology, Molecular Biology, Infectious Diseases, Immunology and Allergy, and Physiology.

Their work covers a variety of scientific topics, including:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • SARS-CoV-2 and COVID-19 Research
  • Cell Adhesion Molecules Research
  • Calcium signaling and nucleotide metabolism
  • COVID-19 Clinical Research Studies
  • Phagocytosis and Immune Regulation

John H. Kehrl has published extensively, with contributions to significant scientific journals and venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Science Signaling
  • Frontiers in Immunology
  • Cell

Some recent papers authored or coauthored by Kehrl include:

  • β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway (2020, Cell)
  • AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5 (2020, The Journal of Immunology)
  • LRRK2 is required for CD38-mediated NAADP-Ca2+signaling and the downstream activation of TFEB (transcription factor EB) in immune cells (2021, Autophagy)
  • A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation (2022, eLife)
  • A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells (2022, Science Signaling)

The scientist collaborates regularly with a group of frequent coauthors, including:

  • Il-Young Hwang
  • Chung Park
  • Serena Li-Sue Yan
  • Claudia Cicala
  • James Arthos

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

    A B Roberts;M B Sporn;R K Assoian;J M Smith

  • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

    John H. Kehrl;Lalage M. Wakefield;Anita B. Roberts;Sonia Jakowlew

  • Activation of Autophagy by Inflammatory Signals Limits IL-1β Production by Targeting Ubiquitinated Inflammasomes for Destruction

    Chong Shan Shi;Kevin Shenderov;Ning Na Huang;Juraj Kabat

  • Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

    J H Kehrl;A B Roberts;L M Wakefield;S Jakowlew

  • Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

    Thomas M. Folks;Kathleen A. Clouse;Jesse Justement;Arnold Rabson

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

    Ned Watson;Maurine E. Linder;Kirk M. Druey;John H. Kehrl

  • Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

    A H Rook;J H Kehrl;L M Wakefield;A B Roberts

  • β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

    Sourish Ghosh;Teegan A. Dellibovi-Ragheb;Adeline Kerviel;Eowyn Pak

  • Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.

    Hannelore Ehrenreich;Robert W. Anderson;Cecil H. Fox;Peter Rieckmann

  • Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

    Guido Poli;Audrey Kinter;Jesse S. Justement;John H. Kehrl

  • Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

    Kirk M. Druey;Kendall J. Blumer;Kendall J. Blumer;Veronica H. Kang;Veronica H. Kang;John H. Kehrl;John H. Kehrl

  • TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

    Chong-Shan Shi;John H. Kehrl

  • SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

    Chong Shan Shi;Hai Yan Qi;Cedric Boularan;Ning Na Huang

  • SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.

    Chong-Shan Shi;Neel R. Nabar;Ning-Na Huang;John H. Kehrl

  • MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

    Chong-Shan Shi;John H. Kehrl

  • Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice

    Kathleen A. Harrison;Joshua Thaler;Samuel L. Pfaff;Hua Gu

Frequent Co-Authors

Anthony S. Fauci
Anthony S. Fauci Georgetown University
Michael B. Sporn
Michael B. Sporn Dartmouth College
Peter R. Williamson
Peter R. Williamson National Institutes of Health
Sergio Lavandero
Sergio Lavandero University of Chile
Daniel J. Klionsky
Daniel J. Klionsky University of Michigan–Ann Arbor
Evelina Gatti
Evelina Gatti Aix-Marseille University
Anita B. Roberts
Anita B. Roberts National Institutes of Health
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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