World's Best Scientists 2026 revealed!
Michael B. Sporn

Michael B. Sporn

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Best Scientists
2025

D-Index & Metrics

Best Scientists

D-Index
178
Citations
132649
World Ranking
649
National Ranking
406

Medicine

D-Index
178
Citations
131653
World Ranking
389
National Ranking
242

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Michael B. Sporn was a researcher affiliated with Dartmouth College in the United States. Their work spanned several fields within Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on Molecular Biology and related subfields such as Pulmonary and Respiratory Medicine, Health, Toxicology and Mutagenesis, Critical Care and Intensive Care Medicine, and Radiology, Nuclear Medicine and Imaging.

The scientific topics that characterized their research included:

  • Genomics, phytochemicals, and oxidative stress
  • Glutathione Transferases and Polymorphisms
  • Coenzyme Q10 studies and effects
  • Heme Oxygenase-1 and Carbon Monoxide
  • Climate Change and Health Impacts
  • Thermal Regulation in Medicine
  • Oral health in cancer treatment

They published in a variety of venues, each contributing to the dissemination of their findings:

  • Journal of Medicinal Chemistry
  • Molecular and Cellular Biology
  • Free Radical Biology and Medicine
  • Molecular Oncology
  • Blood

Michael B. Sporn's recent papers illustrate diverse research interests and chronological progression:

  • CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1, 2020, Journal of Medicinal Chemistry
  • Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction, 2021, Molecular and Cellular Biology
  • Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening, 2022, Free Radical Biology and Medicine
  • The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma, 2023, Molecular Oncology
  • Targeting NLRP3 Inflammasome-Induced Therapy Resistance in ALL, 2020, Blood

The scientist collaborated frequently with several researchers, including:

  • Masayuki Yamamoto
  • John J. Letterio
  • Xiaoli Meng
  • J. Waddington
  • Arun Tailor

Michael B. Sporn was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1998.

Best Publications

  • Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

    A B Roberts;M B Sporn;R K Assoian;J M Smith

  • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

    Ashok B. Kulkarni;Chang-Goo Huh;Dean Becker;Andrew Geiser

  • Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

    Rik Derynck;Julie A. Jarrett;Ellson Y. Chen;Dennis H. Eaton

  • Can dietary beta-carotene materially reduce human cancer rates?

    R. Peto;R. Doll;J. D. Buckley;M. B. Sporn

  • Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

    R K Assoian;A Komoriya;C A Meyers;D M Miller

  • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

    John H. Kehrl;Lalage M. Wakefield;Anita B. Roberts;Sonia Jakowlew

  • Autocrine growth factors and cancer.

    Michael B. Sporn;Anita B. Roberts

  • Autocrine Secretion and Malignant Transformation of Cells

    Michael B. Sporn;George J. Todaro

  • The Retinoids : biology, chemistry, and medicine

    Michael B. Sporn;Anita B. Roberts;DeWitt S. Goodman

  • Transforming growth factor type beta induces monocyte chemotaxis and growth factor production

    Sharon M. Wahl;Denise A. Hunt;Lalage M. Wakefield;Nancy McCartney-Francis

  • Transforming growth factor-beta: biological function and chemical structure

    Michael B. Sporn;Anita B. Roberts;Lalage M. Wakefield;Richard K. Assoian

  • Type beta transforming growth factor: a bifunctional regulator of cellular growth.

    Anita B. Roberts;Mario A. Anzano;Lalage M. Wakefield;Nanette S. Roche

  • Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

    Wayne A. Border;Seiya Okuda;Lucia R. Languino;Michael B. Sporn

  • Peptide Growth Factors and Their Receptors

    健一 新井;James F. Battey;Michael B. Sporn;Anita B. Roberts

  • Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.

    Thomas A. Mustoe;Glenn F. Pierce;Arlen Thomason;Peggy Gramates

  • Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

    M B Sporn;N M Dunlop;D L Newton;J M Smith

  • NRF2 and cancer: the good, the bad and the importance of context

    Michael B. Sporn;Karen T. Liby

  • Expression and secretion of type beta transforming growth factor by activated human macrophages

    Richard K. Assoian;Barbara E. Fleurdelys;Henry C. Stevenson;Paul J. Miller

  • New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

    Anita B. Roberts;Mario A. Anzano;Lois C. Lamb;Joseph M. Smith

  • Recent advances in chemoprevention of cancer.

    Waun Ki Hong;Michael B. Sporn

Frequent Co-Authors

Anita B. Roberts
Anita B. Roberts National Institutes of Health
Tadashi Honda
Tadashi Honda Stony Brook University
Gordon W. Gribble
Gordon W. Gribble Dartmouth College
Kathleen C. Flanders
Kathleen C. Flanders National Institutes of Health
Seong-Jin Kim
Seong-Jin Kim Seoul National University
David Danielpour
David Danielpour Case Western Reserve University
Paturu Kondaiah
Paturu Kondaiah Indian Institute of Science
Robert Lafyatis
Robert Lafyatis University of Pittsburgh
Thomas W. Kensler
Thomas W. Kensler Johns Hopkins University
Curtis C. Harris
Curtis C. Harris National Institutes of Health

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