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Chemistry

D-Index
49
Citations
9352
World Ranking
14754
National Ranking
3767

Overview

Tadashi Honda is affiliated with Stony Brook University in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Immunology, Cell Biology, Organic Chemistry, and Environmental Chemistry as subfields of study.

The main topics of Honda's scientific work include:

  • Genomics, phytochemicals, and oxidative stress
  • Aldose Reductase and Taurine
  • Heme Oxygenase-1 and Carbon Monoxide
  • Immune Cell Function and Interaction
  • Arsenic contamination and mitigation
  • Heavy Metal Exposure and Toxicity
  • Vitamin C and Antioxidants Research

Their recent publications cover various aspects of oxidative stress, metabolism, and biochemical processes:

  • "Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response," 2022, iScience
  • "Downregulation of Keap1 Confers Features of a Fasted Metabolic State," 2020, iScience
  • "The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity," 2022, Redox Biology
  • "Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives," 2022, Journal of Biological Chemistry
  • "Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity," 2020, Environmental Pollution

Honda's frequent co-authors include:

  • Albena T. Dinkova-Kostova
  • Maureen Higgins
  • Sharadha Dayalan Naidu
  • Elena V. Knatko
  • Laureano de la Vega

Common venues for their research publication are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience
  • Redox Biology
  • Journal of Biological Chemistry
  • Environmental Pollution

Best Publications

  • Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

    Albena T. Dinkova-Kostova;Karen T. Liby;Katherine K. Stephenson;W. David Holtzclaw

  • Novel Triterpenoids Suppress Inducible Nitric Oxide Synthase (iNOS) and Inducible Cyclooxygenase (COX-2) in Mouse Macrophages

    Nanjoo Suh;Tadashi Honda;Heather J. Finlay;Aaron Barchowsky

  • A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

    Nanjoo Suh;Yongping Wang;Tadashi Honda;Gordon W. Gribble

  • The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling

    Karen Liby;Thomas Hock;Mark M. Yore;Nanjoo Suh

  • Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

    Melinda S. Yates;Masafumi Tauchi;Fumiki Katsuoka;Kathleen C. Flanders

  • Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

    Tadashi Honda;Barbieann V. Rounds;Lothar Bore;Heather J. Finlay

  • Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1, 9(11)-dien-28-oyl]imidazole

    Melinda S. Yates;Mi Kyoung Kwak;Patricia A. Egner;John D. Groopman

  • Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

    Tadashi Honda;Barbie Ann V. Rounds;Gordon W. Gribble;Nanjoo Suh

  • Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

    Marina Konopleva;Twee Tsao;Peter Ruvolo;Irina Stiouf

  • A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ

    Yongping Wang;Weston W. Porter;Nanjoo Suh;Tadashi Honda

  • Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

    Ritu S. Sharma;David J. Harrison;Dorothy Kisielewski;Diane M. Cassidy

  • The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

    Andrew E. Place;Nanjoo Suh;Charlotte R. Williams;Renee Risingsong

  • A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.

    Tadashi Honda;Yukiko Honda;Frank G. Favaloro;Gordon W. Gribble

  • Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.

    Tadashi Honda;Gordon W. Gribble;Nanjoo Suh;Heather J. Finlay

  • The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

    Karen Liby;Darlene B. Royce;Charlotte R. Williams;Renee Risingsong

  • Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action

    Robin D. Couch;R. Greg Browning;Tadashi Honda;Gordon W. Gribble

  • Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.

    Nanjoo Suh;Anita B Roberts;Stephanie Birkey Reffey;Kohei Miyazono

  • The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.

    Yasumasa Ito;Pramod Pandey;Andrew Place;Michael B. Sporn

  • The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.

    Dharminder Chauhan;Guilan Li;Guilan Li;Klaus Podar;Klaus Podar;Teru Hideshima;Teru Hideshima

  • New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

    Tadashi Honda;Heather J. Finlay;Gordon W. Gribble;Nanjoo Suh

Frequent Co-Authors

Michael B. Sporn
Michael B. Sporn Dartmouth College
Gordon W. Gribble
Gordon W. Gribble Dartmouth College
Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova University of Dundee
Iwao Ojima
Iwao Ojima Stony Brook University
Dale F. Mierke
Dale F. Mierke Dartmouth College
Colin J. Henderson
Colin J. Henderson University of Dundee
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Masami Ishibashi
Masami Ishibashi Chiba University
John D. Hayes
John D. Hayes University of Dundee
Paul Talalay
Paul Talalay Johns Hopkins University School of Medicine

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