D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 66 Citations 25,857 119 World Ranking 3770 National Ranking 1904

Research.com Recognitions

Awards & Achievements

1987 - Member of the National Academy of Sciences

1973 - Fellow of John Simon Guggenheim Memorial Foundation

1965 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Gene

His primary areas of investigation include Biochemistry, Enzyme, Glutathione, Carcinogen and Reductase. Biochemistry is represented through his NADH Dehydrogenase, Oxidoreductase, Enzyme inducer, NAD+ kinase and Quinone research. His Oxidoreductase research is multidisciplinary, incorporating perspectives in Molecular biology and Stereochemistry.

His studies in Enzyme inducer integrate themes in fields like Inducer and Sulforaphane. His Enzyme study incorporates themes from DNA damage and Antioxidant. The study incorporates disciplines such as Cruciferous vegetables and Anticarcinogen in addition to Carcinogen.

His most cited work include:

  • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors (5663 citations)
  • A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. (1386 citations)
  • Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens (1074 citations)

What are the main themes of his work throughout his whole career to date?

Paul Talalay mostly deals with Biochemistry, Enzyme, Stereochemistry, Reductase and NAD+ kinase. His study in NADH Dehydrogenase, Glutathione, Carcinogen, Enzyme inducer and Oxidoreductase is carried out as part of his Biochemistry studies. His research in Enzyme intersects with topics in Inducer, Chromatography, Anticarcinogen and Methionine.

In his study, Intramolecular force and Catalysis is inextricably linked to Isomerase, which falls within the broad field of Stereochemistry. The Reductase study which covers Quinone that intersects with Quinone Reductases and Quinone oxidoreductase. Oxidative stress is closely connected to Flavoprotein in his research, which is encompassed under the umbrella topic of NAD+ kinase.

He most often published in these fields:

  • Biochemistry (56.29%)
  • Enzyme (43.71%)
  • Stereochemistry (26.95%)

What were the highlights of his more recent work (between 2003-2019)?

  • Biochemistry (56.29%)
  • Sulforaphane (11.98%)
  • Enzyme (43.71%)

In recent papers he was focusing on the following fields of study:

His main research concerns Biochemistry, Sulforaphane, Enzyme, Pharmacology and Inducer. NAD+ kinase, KEAP1, Oxidative stress, Quinone oxidoreductase and Quinone are subfields of Biochemistry in which his conducts study. His work in the fields of Sulforaphane, such as Broccoli sprouts, overlaps with other areas such as Glucoraphanin.

His studies deal with areas such as Stereochemistry and Carcinogen as well as Enzyme. His Inducer research includes themes of Cancer research and Cysteine. His Isothiocyanate study combines topics from a wide range of disciplines, such as Macrophage migration inhibitory factor and Anticarcinogen.

Between 2003 and 2019, his most popular works were:

  • Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. (792 citations)
  • NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector (464 citations)
  • Direct and indirect antioxidant properties of inducers of cytoprotective proteins. (353 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Biochemistry

Paul Talalay mainly focuses on Biochemistry, Sulforaphane, Oxidative stress, KEAP1 and Broccoli sprouts. His Biochemistry study frequently draws connections to other fields, such as Bioassay. His work deals with themes such as Glutathione, Crossover study and Excretion, which intersect with Sulforaphane.

Paul Talalay has researched Oxidative stress in several fields, including Antibiotics, Antioxidant and NAD+ kinase, Enzyme. His Enzyme research is multidisciplinary, incorporating elements of Curcumin, Oxidative phosphorylation and Quinone. His biological study deals with issues like Pharmacology, which deal with fields such as Biotechnology and Isothiocyanate.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting Chao Chou;Paul Talalay.
Advances in Enzyme Regulation (1984)

7235 Citations

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

Yuesheng Zhang;Paul Talalay;Cheon Gyu Cho;Gary H. Posner.
Proceedings of the National Academy of Sciences of the United States of America (1992)

2000 Citations

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Jed W. Fahey;Yuesheng Zhang;Paul Talalay.
Proceedings of the National Academy of Sciences of the United States of America (1997)

1599 Citations

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

Ann M. Benson;Markus J. Hunkeler;Paul Talalay.
Proceedings of the National Academy of Sciences of the United States of America (1980)

1079 Citations

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Nobunao Wakabayashi;Albena T. Dinkova-Kostova;W. David Holtzclaw;Moon Il Kang.
Proceedings of the National Academy of Sciences of the United States of America (2004)

1023 Citations

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

Jed W. Fahey;Xavier Haristoy;Patrick M. Dolan;Thomas W. Kensler.
Proceedings of the National Academy of Sciences of the United States of America (2002)

997 Citations

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

Yuesheng Zhang;Thomas W. Kensler;Cheon Gyu Cho;Gary H. Posner.
Proceedings of the National Academy of Sciences of the United States of America (1994)

946 Citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

P Talalay;M J De Long;H J Prochaska.
Proceedings of the National Academy of Sciences of the United States of America (1988)

788 Citations

Anticarcinogenic Activities of Organic Isothiocyanates: Chemistry and Mechanisms

Yuesheng Zhang;Paul Talalay.
Cancer Research (1994)

751 Citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

Albena T. Dinkova-Kostova;Michael A. Massiah;Richard E. Bozak;Ronald J. Hicks.
Proceedings of the National Academy of Sciences of the United States of America (2001)

642 Citations

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