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D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
38032
World Ranking
1016
National Ranking
614

Medicine

D-Index
107
Citations
36984
World Ranking
6324
National Ranking
3372

Overview

Steven Grant is affiliated with Virginia Commonwealth University in the United States and has a significant research presence in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans key subfields including Molecular Biology, Hematology, Genetics, Oncology, and Epidemiology.

Their research topics notably focus on Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, Histone Deacetylase Inhibitors Research, Chronic Myeloid Leukemia Treatments, Multiple Myeloma Research and Treatments, Myeloproliferative Neoplasms: Diagnosis and Treatment, and Cell death mechanisms and regulation.

Frequent coauthors in their publications include:

  • Keri Maher
  • Ian Bouligny
  • Graeme Murray
  • Juhi Gor
  • Nolan A. Wages

Steven Grant's research has been published in a variety of scientific venues. The most frequent publication platforms include:

  • Blood
  • Journal of Clinical Oncology
  • Cancer Chemotherapy and Pharmacology
  • Clinical Cancer Research
  • Chemistry - A European Journal

Selected recent publications illustrate the scope and focus of their work:

  • Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives, 2022, Blood Reviews
  • Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses, 2024, Nature Cancer
  • Phase 1 study of belinostat and adavosertib in patients with relapsed or refractory myeloid malignancies, 2023, Cancer Chemotherapy and Pharmacology
  • Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax, 2023, Clinical Cancer Research
  • Venetoclax with decitabine or azacitidine in the first-line treatment of acute myeloid leukemia, 2023, eJHaem

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

    Marcel Verheij;Marcel Verheij;Ron Bose;Xin Hua Lin;Bei Yao

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • MAPK pathways in radiation responses.

    Paul Dent;Adly Yacoub;Paul B Fisher;Michael P Hagan

  • Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

    W D Jarvis;R N Kolesnick;F A Fornari;R S Traylor

  • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors.

    Xin-Yan Pei;Yun Dai;Steven Grant

  • Stress and radiation-induced activation of multiple intracellular signaling pathways.

    Paul Dent;Adly Yacoub;Joseph Contessa;Ruben Caron

  • Induction of Apoptotic DNA Fragmentation and Cell Death in HL-60 Human Promyelocytic Leukemia Cells by Pharmacological Inhibitors of Protein Kinase C

    W D Jarvis;A J Turner;L F Povirk;R S Traylor

  • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

    Shuang Chen;Yun Dai;Hisashi Harada;Paul Dent

  • Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53.

    J A Vrana;R H Decker;C R Johnson;Z Wang

  • Signal transduction and cellular radiation responses

    Rupert K. Schmidt-Ullrich;Paul Dent;Steven Grant;Ross B. Mikkelsen

  • Radiation-induced cell signaling: inside-out and outside-in

    Kristoffer Valerie;Adly Yacoub;Michael P. Hagan;David T. Curiel

  • Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease

    Robert J McKallip;Catherine Lombard;Michael T Fisher;Billy R Martin

  • Differentiation therapy of human cancer: basic science and clinical applications

    Magdalena Leszczyniecka;Terry Roberts;Paul Dent;Steven Grant

  • Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation

    Mohamed Rahmani;Eric Maynard Davis;Cheryl Bauer;Paul Dent

  • The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

    Chunrong Yu;Mohamed Rahmani;Daniel Conrad;Mark Subler

  • Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation

    Yun Dai;Mohamed Rahmani;Paul Dent;Steven Grant

  • Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis

    Liang Qiao;Elaine Studer;Kevin Leach;Robert McKinstry

  • A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

    Steven W. Paugh;Barbara S. Paugh;Mohamed Rahmani;Dmitri Kapitonov

  • Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.

    Prithviraj Bose;Yun Dai;Steven Grant

Frequent Co-Authors

Paul Dent
Paul Dent Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Mohamed Rahmani
Mohamed Rahmani Khalifa University
Adly Yacoub
Adly Yacoub Virginia Commonwealth University
David T. Curiel
David T. Curiel Washington University in St. Louis
John D. Roberts
John D. Roberts Yale University
Devanand Sarkar
Devanand Sarkar Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Jonathan W. Friedberg
Jonathan W. Friedberg University of Rochester

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