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Overview

Kapil N. Bhalla is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Hematology, Genetics, Oncology, and Public Health, Environmental and Occupational Health.

The scientist's work addresses several main research topics including:

  • Acute Myeloid Leukemia Research
  • Protein Degradation and Inhibitors
  • Multiple Myeloma Research and Treatments
  • Histone Deacetylase Inhibitors Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chromatin Remodeling and Cancer
  • Chronic Myeloid Leukemia Treatments

Bhalla has published extensively in multiple venues, with frequent contributions to:

  • Blood
  • Cancer Research
  • Blood Cancer Journal
  • JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
  • Clinical Lymphoma Myeloma & Leukemia

Their recent notable papers include:

  • "Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics" (2020) published in Nature Communications
  • "Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)" (2022) published in Blood Cancer Journal
  • "Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia" (2021) published in Nature Communications
  • "Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia" (2022) published in Journal of Clinical Oncology
  • "Patterns of Resistance Differ in Patients with Acute Myeloid Leukemia Treated with Type I versus Type II FLT3 Inhibitors" (2020) published in Blood Cancer Discovery

Kapil N. Bhalla has collaborated frequently with several coauthors, including:

  • Courtney D. DiNardo
  • Warren Fiskus
  • Tapan M. Kadia
  • Christopher P. Mill
  • Naval Daver

The accumulated body of work reflects a sustained research focus on acute myeloid leukemia and related hematological malignancies, encompassing mechanistic studies, therapeutic strategies, and clinical trials.

Best Publications

  • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.

    Hagop M Kantarjian;Francis Giles;Lydia Wunderle;Kapil Bhalla

  • Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

    Rui Hua Xu;Helene Pelicano;Yan Zhou;Jennifer S. Carew

  • Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90 A NOVEL BASIS FOR ANTILEUKEMIA ACTIVITY OF HISTONE DEACETYLASE INHIBITORS

    Purva Bali;Michael Pranpat;James Bradner;Maria Balasis

  • Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome–positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance

    Hagop M. Kantarjian;Francis Giles;Norbert Gattermann;Kapil Bhalla

  • Microtubule-targeted anticancer agents and apoptosis.

    Kapil N Bhalla

  • The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

    Alejandro Villagra;Fengdong Cheng;Hong Wei Wang;Ildelfonso Suarez

  • Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results

    Hagop M. Kantarjian;Francis J. Giles;Kapil N. Bhalla;Javier A. Pinilla-Ibarz

  • Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

    Siddharth Balachandran;Caryn N. Kim;Wen Chen Yeh;Tak W. Mak

  • Clinical experience with the BCL2‐inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies

    Courtney D. DiNardo;Caitlin R. Rausch;Christopher Benton;Tapan Kadia

  • Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies

    Kapil N. Bhalla

  • Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

    Prince George;Purva Bali;Srinivas Annavarapu;Anna Scuto

  • Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3

    Gustavo P. Amarante-Mendes;Caryn Naekyung Kim;Linda Liu;Yue Huang

  • SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

    Yonghua Yang;Wei Fu;Jiandong Chen;Jiandong Chen;Nancy Olashaw;Nancy Olashaw

  • Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells

    Ramadevi Nimmanapalli;Lianne Fuino;Purva Bali;Maura Gasparetto

  • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.

    Warren Fiskus;Yongchao Wang;Arun Sreekumar;Kathleen M. Buckley

  • CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs

    Guofu Fang;Caryn Naekyung Kim;Charles L. Perkins;Nimmanapalli Ramadevi

  • Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

    Siddharth Balachandran;Siddharth Balachandran;P. Christopher Roberts;P. Christopher Roberts;Todd Kipperman;Kapil N. Bhalla

  • Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

    Kapil Bhalla;Ana Maria Ibrado;Elena Tourkina;Caroline Tang

  • Targeting HSP90 for cancer therapy

    Devalingam Mahalingam;R. Swords;J. S. Carew;Steffan T Nawrocki

  • A Phase I Study of Intravenous LBH589, a Novel Cinnamic Hydroxamic Acid Analogue Histone Deacetylase Inhibitor, in Patients with Refractory Hematologic Malignancies

    Francis Giles;Thomas Fischer;Jorge Cortes;Guillermo Garcia-Manero

Frequent Co-Authors

Peter Atadja
Peter Atadja Novartis (Switzerland)
Hagop M. Kantarjian
Hagop M. Kantarjian The University of Texas MD Anderson Cancer Center
Francis J. Giles
Francis J. Giles Northwestern University
Jorge E. Cortes
Jorge E. Cortes Augusta University
Guillermo Garcia-Manero
Guillermo Garcia-Manero The University of Texas MD Anderson Cancer Center
Srdan Verstovsek
Srdan Verstovsek The University of Texas MD Anderson Cancer Center
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
Farhad Ravandi
Farhad Ravandi The University of Texas MD Anderson Cancer Center
Elias Jabbour
Elias Jabbour The University of Texas MD Anderson Cancer Center
Oliver G. Ottmann
Oliver G. Ottmann Cardiff University

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