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Biology and Biochemistry

D-Index
131
Citations
64717
World Ranking
389
National Ranking
255

Overview

Thomas W. Kensler is affiliated with Johns Hopkins University in the United States and has made contributions primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Biology, Public Health, Environmental and Occupational Health, Physiology, Epidemiology, and Health, Toxicology and Mutagenesis.

The main topics of Kensler's research include:

  • Genomics, phytochemicals, and oxidative stress
  • Nutritional Studies and Diet
  • Glutathione Transferases and Polymorphisms
  • Liver Disease Diagnosis and Treatment
  • Synthesis and Biological Evaluation
  • Health, Environment, Cognitive Aging
  • Air Quality and Health Impacts

Kensler has published research in several frequent venues, reflecting a focus on redox biology and toxicology as well as molecular and biological communication. These publication venues include:

  • Redox Biology
  • Toxins
  • Communications Biology
  • Antioxidants and Redox Signaling
  • International Journal of Molecular Sciences

Among recent papers authored or co-authored by Kensler are:

  • Current Landscape of NRF2 Biomarkers in Clinical Trials, 2020, Antioxidants
  • Biomarkers of NRF2 signalling: Current status and future challenges, 2024, Redox Biology
  • Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice, 2020, Kidney International
  • Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction, 2020, Antioxidants and Redox Signaling
  • The Challenges of Designing and Implementing Clinical Trials With Broccoli Sprouts... and Turning Evidence Into Public Health Action, 2021, Frontiers in Nutrition

Frequent co-authors collaborating with Kensler include:

  • Masayuki Yamamoto
  • Yoko Yagishita
  • Jianguo Chen
  • John D. Groopman
  • Nobunao Wakabayashi

Best Publications

  • Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

    Thomas W. Kensler;Nobunao Wakabayashi;Shyam Biswal

  • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

    Rajesh K. Thimmulappa;Kim H. Mai;Sorachai Srisuma;Thomas W. Kensler

  • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.

    Minerva Ramos-Gomez;Mi Kyoung Kwak;Patrick M. Dolan;Ken Itoh

  • The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

    Masayuki Yamamoto;Thomas W. Kensler;Hozumi Motohashi

  • Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

    Nobunao Wakabayashi;Albena T. Dinkova-Kostova;W. David Holtzclaw;Moon Il Kang

  • Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

    Rajesh K. Thimmulappa;Hannah Lee;Tirumalai Rangasamy;Sekhar P. Reddy

  • Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

    Tirumalai Rangasamy;Chung Y. Cho;Rajesh K. Thimmulappa;Lijie Zhen

  • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

    Jed W. Fahey;Xavier Haristoy;Patrick M. Dolan;Thomas W. Kensler

  • Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

    Antonio Cuadrado;Ana I. Rojo;Geoffrey Wells;John D. Hayes

  • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

    Yuesheng Zhang;Thomas W. Kensler;Cheon Gyu Cho;Gary H. Posner

  • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

    R. H. Hruban;A. D.M. Van Mansfeld;G. J.A. Offerhaus;D. H.J. Van Weering

  • Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

    Deepti Malhotra;Elodie Portales-Casamar;Anju Singh;Siddhartha Srivastava

  • Role of NRF2 in protection against hyperoxic lung injury in mice

    Hye Youn Cho;Anne E. Jedlicka;Sekhar P.M. Reddy;Thomas W. Kensler

  • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

    Mi Kyoung Kwak;Nobunao Wakabayashi;Nobunao Wakabayashi;Ken Itoh;Hozumi Motohashi

  • Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

    Thomas W. Kensler;Bill D. Roebuck;Gerald N. Wogan;John D. Groopman

  • The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

    Junko Wakabayashi;Zhongyan Zhang;Nobunao Wakabayashi;Yasushi Tamura

  • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.

    Mi Kyoung Kwak;Ken Itoh;Masayuki Yamamoto;Thomas W. Kensler

  • Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.

    Tirumalai Rangasamy;Jia Guo;Wayne A. Mitzner;Jessica Roman

  • Oxidative mechanisms in carcinogenesis.

    K Z Guyton;T W Kensler

  • When NRF2 Talks, Who's Listening?

    Nobunao Wakabayashi;Stephen L. Slocum;John J. Skoko;Soona Shin

Frequent Co-Authors

John D. Groopman
John D. Groopman Johns Hopkins University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Gary H. Posner
Gary H. Posner Johns Hopkins University
Shyam Biswal
Shyam Biswal Johns Hopkins University
Alvaro Muñoz
Alvaro Muñoz Johns Hopkins University
Thomas R. Sutter
Thomas R. Sutter University of Memphis
Lisa P. Jacobson
Lisa P. Jacobson Johns Hopkins University
Jed W. Fahey
Jed W. Fahey Johns Hopkins University
Michael A. Trush
Michael A. Trush Johns Hopkins University
Nancy E. Davidson
Nancy E. Davidson University of Washington

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