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Biology and Biochemistry

D-Index
64
Citations
14431
World Ranking
9684
National Ranking
44

Overview

Hsin-Chen Lee is affiliated with National Yang Ming University in Taiwan and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their publication record encompasses 30 works in biochemistry, genetics, and molecular biology, and 29 in medicine, with additional specialization in molecular biology, cancer research, physiology, pulmonary and respiratory medicine, and oncology.

The main topics addressed in Lee's research include:

  • Cancer, Hypoxia, and Metabolism
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Endoplasmic Reticulum Stress and Disease
  • Tryptophan and Brain Disorders
  • Epigenetics and DNA Methylation
  • GDF15 and Related Biomarkers

Their frequent co-authors are:

  • Sheng-Fan Wang
  • Ling-Ming Tseng
  • Yuh-Lih Chang
  • Chen-Huan Chen
  • Chian-Ying Chou

Lee's research often appears in journals such as:

  • Cancers
  • Journal of the Chinese Medical Association
  • Clinical Cancer Research
  • Journal of Biomedical Science
  • BMC Medical Education

Recent publications include:

  • Role of mitochondrial alterations in human cancer progression and cancer immunity, 2023, Journal of Biomedical Science
  • Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression, 2020, Cancers
  • Role of the mitochondrial stress response in human cancer progression, 2020, Experimental Biology and Medicine
  • Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression, 2020, EBioMedicine
  • Circulating microRNAs Associated With Reversible Cerebral Vasoconstriction Syndrome, 2020, Annals of Neurology

Best Publications

  • Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress.

    Hsin Chen Lee;Yau Huei Wei

  • Oxidative Stress, Mitochondrial DNA Mutation, and Impairment of Antioxidant Enzymes in Aging

    Yau Huei Wei;Hsin Chen Lee

  • Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells.

    Hsin Chen Lee;Pen Hui Yin;Ching You Lu;Chin Wen Chi

  • Mitochondrial DNA Mutations and Mitochondrial DNA Depletion in Breast Cancer

    Ling Ming Tseng;Pen Hui Yin;Pen Hui Yin;Chin Wen Chi;Chin Wen Chi;Chih Yi Hsu

  • Mitochondrial role in life and death of the cell.

    Hsin Chen Lee;Yau Huei Wei

  • Increase in Mitochondrial Mass in Human Fibroblasts under Oxidative Stress and during Replicative Cell Senescence

    Hsin Chen Lee;Pen Hui Yin;Chin Wen Chi;Yau Huei Wei

  • Oxidative Damage and Mutation to Mitochondrial DNA and Age-dependent Decline of Mitochondrial Respiratory Functiona

    Yau Huei Wei;Ching You Lu;Hsin Chen Lee;Cheng Yoong Pang

  • Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma

    Hsin Chen Lee;Shu Hui Li;Jin Ching Lin;Cheng Chung Wu

  • Mitochondrial genome instability and mtDNA depletion in human cancers.

    Hsin Chen Lee;Pen Hui Yin;Jin Ching Lin;Cheng Chung Wu

  • Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.

    Hsin Chen Lee;Yau Huei Wei

  • Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

    Hsin Chen Lee;Cheng Yoong Pang;Hueih Shing Hsu;Yau Huei Wei

  • Mitochondria and aging.

    Hsin Chen Lee;Yau Huei Wei;Yau Huei Wei

  • Role of mitochondrial dysfunction in cancer progression

    Chia Chi Hsu;Ling Ming Tseng;Hsin Chen Lee

  • CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway.

    Meng-Shian Chen;Sheng-Fan Wang;Sheng-Fan Wang;Chih-Yi Hsu;Pen-Hui Yin

  • Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma

    P H Yin;H C Lee;H C Lee;G Y Chau;G Y Chau;Y T Wu

  • Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin.

    Ching You Lu;Hsin Chen Lee;Huei Jyh Fahn;Yau Huei Wei

  • Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung

    Hsin Chen Lee;Ching You Lu;Huei Jyh Fahn;Yau Huei Wei

  • Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system.

    Yau Huei Wei;Ching You Lu;Chia Yu Wei;Yi Shing Ma

  • Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis.

    Chi Wei Wu;Yueh Hsin Ping;Yueh Hsin Ping;Jiin Cherng Yen;Jiin Cherng Yen;Chia Yu Chang

  • Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer

    Ling-Ming Tseng;Pen-Hui Yin;Chin-Wen Chi;Chih-Yi Hsu

Frequent Co-Authors

Yau-Huei Wei
Yau-Huei Wei Changhua Christian Hospital
Shih-Hwa Chiou
Shih-Hwa Chiou National Yang Ming Chiao Tung University
Tzeng-Ji Chen
Tzeng-Ji Chen Taipei Veterans General Hospital
Chun-Yu Liu
Chun-Yu Liu Boston University
Jen Chuen Hsieh
Jen Chuen Hsieh National Yang Ming Chiao Tung University
Cheng-Ta Li
Cheng-Ta Li Taipei Veterans General Hospital
Muh-Hwa Yang
Muh-Hwa Yang Taipei Veterans General Hospital
Shih-Chieh Hung
Shih-Chieh Hung China Medical University
Shuu-Jiun Wang
Shuu-Jiun Wang National Yang Ming Chiao Tung University
Hsien-Da Huang
Hsien-Da Huang Chinese University of Hong Kong, Shenzhen

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