Michael Maes

Research.com Recognitions

• 2026 - Research.com Neuroscience in China Leader Award
• 2023 - Research.com Medicine in Thailand Leader Award
• 2022 - Research.com Medicine in Thailand Leader Award

Overview

Best Publications

• So depression is an inflammatory disease, but where does the inflammation come from?

  Michael Berk;Lana Williams;Lana Williams;Felice N Jacka;Felice N Jacka;Adrienne O'Neil;Adrienne O'Neil

  1633
  Citations

• Cytokines and major depression.

  Olga J.G. Schiepers;Marieke C. Wichers;Michael Maes

  1607
  Citations

• Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies.

  C. A. Köhler;T. H. Freitas;M. Maes;N. Q. De Andrade

  1400
  Citations

• A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.

  Michael Maes;Piotr Galecki;Yong Seun Chang;Michael Berk;Michael Berk

  1334
  Citations

• Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors

  Michael Berk;Flavio P Kapczinski;Ana Cristina Andreazza;Ana Cristina Andreazza;Olivia Dean;Olivia Dean

  1330
  Citations

• Evidence for an immune response in major depression: a review and hypothesis

  Michael Maes

  1247
  Citations

• The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

  Michael Maes;Raz Yirmyia;Jens Noraberg;Stefan Brene

  1128
  Citations

• The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety

  Michael Maes;Cai Song;Aihua Lin;Raf De Jongh

  1004
  Citations

• INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION

  M Maes;E Bosmans;R De Jongh;G Kenis

  900
  Citations

• The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.

  M. Maes;B.E. Leonard;A.M. Myint;M. Kubera

  874
  Citations

• Major depression and activation of the inflammatory response system.

  Michael Maes

  846
  Citations

• Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

  Michael Maes;Herbert Y. Meltzer;Eugène Bosmans;Raf Bergmans

  820
  Citations

• Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression.

  Brian Leonard;Michael Maes

  742
  Citations

• The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

  Michael Maes;Marta Kubera;Jean-Claude Leunis

  740
  Citations

• Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

  Michael Maes;Michael Berk;Lisa Goehler;Cai Song

  725
  Citations

• Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression.

  Michael Maes

  659
  Citations

• Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

  Michael Maes;Armand Christophe;Joris Delanghe;Carlo Altamura

  638
  Citations

• The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications.

  S Moylan;M Maes;N R Wray;M Berk

  629
  Citations

• Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy.

  L Capuron;A Ravaud;P J Neveu;A H Miller

  618
  Citations

• Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids.

  Michael Maes;Ronald Smith;Armand Christophe;Paul Cosyns

  578
  Citations