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Genetics

D-Index
99
Citations
33792
World Ranking
782
National Ranking
390

Molecular Biology

D-Index
99
Citations
33792
World Ranking
555
National Ranking
303

Overview

Carlos T. Moraes is affiliated with the University of Miami in the United States. Their research is primarily situated within the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology and Clinical Biochemistry. Subfields within their work also include Cancer Research, Genetics, and Cellular and Molecular Neuroscience.

Their scientific output includes numerous publications, with recurrent appearances in notable journals such as Nature Communications, EMBO Molecular Medicine, Trends in Genetics, Journal of Biological Chemistry, and Diabetes.

Key areas of research for Carlos T. Moraes encompass Mitochondrial Function and Pathology, Metabolism and Genetic Disorders, and CRISPR and Genetic Engineering. Additional topics of interest cover ATP Synthase and ATPases Research, Cancer, Hypoxia, and Metabolism, Genetic Neurodegenerative Diseases, and Metabolism, Diabetes, and Cancer.

Among their recent published papers are the following:

  • Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV, 2020, The EMBO Journal
  • Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency, 2020, Nature Communications
  • Mitochondrial DNA heteroplasmy in disease and targeted nuclease-based therapeutic approaches, 2020, EMBO Reports
  • Nuclear-Mitochondrial Interactions, 2022, Biomolecules
  • ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly, 2021, Cell Reports

Frequent collaborators in their research include Sandra R. Bacman, Francisca Díaz, Nadee Nissanka, Jose Domingo Barrera-Paez, and Milena Pinto.

Publication venues where Carlos T. Moraes has contributed multiple times include:

  • Nature Communications
  • EMBO Molecular Medicine
  • Trends in Genetics
  • Journal of Biological Chemistry
  • Diabetes

Their work addresses complex interactions and mechanisms related to mitochondrial integrity and pathology, genetic disorders of metabolism, and molecular genetic tools such as CRISPR for therapeutic approaches.

Best Publications

  • Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

    Ursula Fünfschilling;Lotti Marianna Supplie;Don Mahad;Don Mahad;Susann Boretius

  • Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome

    Carlos T. Moraes;Salvatore Dimauro;Massimo Zeviani;Anne Lombes

  • Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

    M. Zeviani;C. T. Moraes;S. DiMauro;H. Nakase

  • Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

    Tina Wenz;Susana G. Rossi;Richard L. Rotundo;Bruce M. Spiegelman

  • A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA

    Eric A. Schon;Rosario Rizzuto;Carlos T. Moraes;Hirofumi Nakase

  • mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.

    Carlos T. Moraes;Sara Shanske;Hans Jürgen Tritschler;June R. Aprille

  • The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

    Eric L. Bell;Tatyana A. Klimova;James Eisenbart;Carlos T. Moraes

  • Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

    E. Arnaudo;S. Shanske;S. DiMauro;E.A. Schon

  • MELAS: Clinical features, biochemistry, and molecular genetics

    E. Ciafaloni;E. Ricci;S. Shanske;C. T. Moraes

  • Respiratory Complex III Is Required to Maintain Complex I in Mammalian Mitochondria

    Rebeca Acı́n-Pérez;Marı́a Pilar Bayona-Bafaluy;Marı́a Pilar Bayona-Bafaluy;Patricio Fernández-Silva;Raquel Moreno-Loshuertos

  • Reactive oxygen species and mitochondrial diseases.

    Ilias G. Kirkinezos;Carlos T. Moraes

  • Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer.

    Robert P. Lanza;Jose B. Cibelli;Francisca Diaz;Carlos T. Moraes

  • Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

    Sandra R Bacman;Siôn L Williams;Milena Pinto;Susana Peralta

  • Titrating the effects of mitochondrial complex I impairment in the cell physiology.

    Antoni Barrientos;Carlos T. Moraes

  • Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA

    Shuji Mita;Rosario Rizzuto;Carlos T. Moraes;Sara Shanske

  • What regulates mitochondrial DNA copy number in animal cells

    Carlos T Moraes

  • RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype

    Tina Wenz;Francisca Diaz;Bruce M. Spiegelman;Carlos T. Moraes

  • Pattern of Organization of Human Mitochondrial Pseudogenes in the Nuclear Genome

    Markus Woischnik;Carlos T. Moraes

  • The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle.

    C T Moraes;E Ricci;E Bonilla;S DiMauro

  • Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

    Nadee Nissanka;Carlos T. Moraes

Frequent Co-Authors

Salvatore DiMauro
Salvatore DiMauro Columbia University
Eric A. Schon
Eric A. Schon Columbia University Medical Center
Eduardo Bonilla
Eduardo Bonilla Columbia University
Massimo Zeviani
Massimo Zeviani University of Padua
Sara Shanske
Sara Shanske Columbia University Medical Center
Giovanni Manfredi
Giovanni Manfredi Cornell University
Antoni Barrientos
Antoni Barrientos University of Miami
Stephan Züchner
Stephan Züchner University of Miami
Walter G. Bradley
Walter G. Bradley University of Miami

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