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Giovanni Manfredi

Giovanni Manfredi

D-Index & Metrics

Molecular Biology

D-Index
83
Citations
19273
World Ranking
912
National Ranking
482

Overview

Giovanni Manfredi is affiliated with Cornell University in the United States. Their research contributions span multiple areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on neurodegenerative diseases and mitochondrial functions.

The primary fields of study for Manfredi include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their work further specializes in subfields such as:

  • Molecular Biology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Physiology
  • Genetics

Manfredi's main research topics cover:

  • Amyotrophic Lateral Sclerosis Research
  • Mitochondrial Function and Pathology
  • Genetic Neurodegenerative Diseases
  • Neurogenetic and Muscular Disorders Research
  • Endoplasmic Reticulum Stress and Disease
  • Biochemical Acid Research Studies
  • Adipose Tissue and Metabolism

Among their recent publications are:

  • "Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration" (2022) published in Cell
  • "Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations" (2020) published in EMBO Reports
  • "Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes" (2021) published in Autophagy
  • "Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy" (2022) published in Cell Reports
  • "Effects of PB-TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts" (2022) published in Annals of Clinical and Translational Neurology

Frequent co-authors who have collaborated with Manfredi include:

  • Csaba Konràd
  • Hibiki Kawamata
  • Nicole M. Sayles
  • Gabriella Casalena
  • Kevin McAvoy

Manfredi regularly publishes in several key scientific venues, with the most common being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • EMBO Reports
  • Research Square (Research Square)
  • Scientific Reports
  • Human Molecular Genetics

Best Publications

  • Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

    Marina Mattiazzi;Marilena D'Aurelio;Carl D. Gajewski;Katherine Martushova

  • Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation

    Rebeca Acin-Perez;Eric Salazar;Margarita Kamenetsky;Jochen Buck

  • Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

    Prashant Mishra;Valerio Carelli;Giovanni Manfredi;David C. Chan

  • Neuronal degeneration and mitochondrial dysfunction

    Eric A. Schon;Giovanni Manfredi

  • Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

    Falk R. Wiedemann;Giovanni Manfredi;Christian Mawrin;M. Flint Beal

  • IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

    Minkyung Song;Tito A. Sandoval;Chang-Suk Chae;Sahil Chopra

  • Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

    Jordi Magrané;Czrina Cortez;Wen-Biao Gan;Giovanni Manfredi

  • Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

    Der-Fen Suen;Derek P. Narendra;Atsushi Tanaka;Giovanni Manfredi

  • Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis

    Yujiro Shidara;Kumi Yamagata;Takashi Kanamori;Kazutoshi Nakano

  • Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.

    Giovanni Manfredi;Jin Fu;Jin Fu;Joseline Ojaimi;James E Sadlock;James E Sadlock

  • Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy

    John Guy;Xiaoping Qi;Francesco Pallotti;Eric A. Schon

  • Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice.

    Maria Damiano;Anatoly A. Starkov;Susanne Petri;Kathuna Kipiani

  • Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice

    Chetan Vijayvergiya;M. Flint Beal;Jochen Buck;Giovanni Manfredi

  • Measurements of ATP in mammalian cells.

    Giovanni Manfredi;Lichuan Yang;Carl D Gajewski;Marina Mattiazzi

  • Mitochondrial dysfunction and its role in motor neuron degeneration in ALS

    Giovanni Manfredi;Zuoshang Xu

  • The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants

    Marina Mattiazzi;Chetan Vijayvergiya;Carl D. Gajewski;Darryl C. DeVivo

  • Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

    Suzanne M. Cloonan;Suzanne M. Cloonan;Kimberly Glass;Kimberly Glass;Maria E. Laucho-Contreras;Abhiram R. Bhashyam

  • Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

    Marjatta Son;Krishna Puttaparthi;Hibiki Kawamata;Bhagya Rajendran

  • The role of mitochondria in inherited neurodegenerative diseases.

    Jennifer Q. Kwong;M. Flint Beal;Giovanni Manfredi

  • Mitochondrial dysfunction and intracellular calcium dysregulation in ALS.

    Hibiki Kawamata;Giovanni Manfredi

Frequent Co-Authors

Paolo Girardi
Paolo Girardi Sapienza University of Rome
Eric A. Schon
Eric A. Schon Columbia University Medical Center
M. Flint Beal
M. Flint Beal Cornell University
Georgios D. Kotzalidis
Georgios D. Kotzalidis Sapienza University of Rome
Anatoly A. Starkov
Anatoly A. Starkov Cornell University
Isabella Pacchiarotti
Isabella Pacchiarotti University of Barcelona
Costantino Iadecola
Costantino Iadecola Cornell University
Carlos T. Moraes
Carlos T. Moraes University of Miami
Stefano Ferracuti
Stefano Ferracuti Sapienza University of Rome
Salvatore DiMauro
Salvatore DiMauro Columbia University

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