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Michael Wiese

Michael Wiese

D-Index & Metrics

Chemistry

D-Index
42
Citations
5080
World Ranking
17634
National Ranking
1276

Overview

Michael Wiese is a researcher affiliated with the University of Bonn in Germany. Their research predominantly centers on medicine, with significant contributions to oncology, infectious diseases, molecular biology, and computational theory and mathematics. The work spans a variety of specialized topics that include drug transport and resistance mechanisms, HIV/AIDS drug development and treatment, pharmacological effects and toxicity studies, computational drug discovery methods, chemical synthesis and analysis, cancer therapeutics and mechanisms, and cholesterol and lipid metabolism.

Wiese's recent scholarly output includes the following publications:

  • C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors, 2021, Journal of Medicinal Chemistry
  • The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP, 2020, Cells
  • Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists, 2020, Journal of Medicinal Chemistry
  • Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA), 2021, Computational and Structural Biotechnology Journal
  • Structural feature-driven pattern analysis for multitarget modulator landscapes, 2021, Bioinformatics

Wiese has collaborated frequently with the following coauthors:

  • Vigneshwaran Namasivayam
  • Katja Silbermann
  • Sven Marcel Stefan
  • Jens Pahnke
  • Sahel Vahdati

Several scientific journals have served as common venues for Wiese's research publications, including:

  • Journal of Medicinal Chemistry
  • Cells
  • Computational and Structural Biotechnology Journal
  • Bioinformatics
  • European Journal of Medicinal Chemistry

Best Publications

  • Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines.

    Henrik Mueller;Matthias U. Kassack;Michael Wiese

  • Structure-activity relationships of multidrug resistance reversers.

    Michael Wiese;Ilza K. Pajeva

  • Structure–activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP)

    Anne Pick;Henrik Müller;Ralf Mayer;Britta Haenisch

  • Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

    Ilza K Pajeva;Michael Wiese

  • Drug-membrane interactions : analysis, drug distribution, modeling

    Joachim K. Seydel;Michael Wiese

  • Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.

    Kapil Juvale;Veronika F.S. Pape;Michael Wiese

  • Molecular Modeling of Phenothiazines and Related Drugs As Multidrug Resistance Modifiers: A Comparative Molecular Field Analysis Study

    Ilza Pajeva;Michael Wiese

  • Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance

    Joachim K. Seydel;Eugene A. Coats;Hans Peter Cordes;Michael Wiese

  • NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

    Sabine Meis;Alexandra Hamacher;Darunee Hongwiset;Claudia Marzian

  • Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).

    Anne Pick;Henrik Müller;Michael Wiese

  • Synthesis and Structure−Activity Relationships of Suramin-Derived P2Y11 Receptor Antagonists with Nanomolar Potency

    Heiko Ullmann;Sabine Meis;Darunee Hongwiset;Claudia Marzian

  • Combined Pharmacophore Modeling, Docking, and 3D QSAR Studies of ABCB1 and ABCC1 Transporter Inhibitors

    Ilza K. Pajeva;Ilza K. Pajeva;Christoph Globisch;Michael Wiese

  • Specific inhibitors of the breast cancer resistance protein (BCRP).

    Anne Pick;Werner Klinkhammer;Michael Wiese

  • Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.

    Veronika F.S. Pape;Veronika F.S. Pape;Szilárd Tóth;András Füredi;Kornélia Szebényi

  • Tyrosine Kinase Inhibitors Influence ABCG2 Expression in EGFR-Positive MDCK BCRP Cells via the PI3K/Akt Signaling Pathway

    Anne Pick;Michael Wiese

  • Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.

    Kapil Juvale;Katja Stefan;Michael Wiese

  • Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).

    Kapil Juvale;Jennifer Gallus;Michael Wiese

  • Determination of dissociation constants of cephalosporins by capillary zone electrophoresis

    Yahya Mrestani;Reinhard Neubert;Angela Munk;Michael Wiese

  • Identification of Putative Binding Sites of P-glycoprotein Based on its Homology Model

    Christoph Globisch;Ilza K. Pajeva;Ilza K. Pajeva;Michael Wiese

  • Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability.

    I. K. Pajeva;M. Wiese;H. P. Cordes;J. K. Seydel

  • Structure-function relationships of multidrug resistance P-glycoprotein.

    Ilza K Pajeva;Christoph Globisch;Michael Wiese

  • In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques

    Veronika Jekerle;Werner Klinkhammer;Deborah A. Scollard;Kerstin Breitbach

  • HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).

    Sebastian C Köhler;Michael Wiese

  • 4-Substituted-2-phenylquinazolines as inhibitors of BCRP.

    Kapil Juvale;Michael Wiese

  • Functional assay and structure–activity relationships of new third-generation P-glycoprotein inhibitors

    Henrik Müller;Ilza K. Pajeva;Ilza K. Pajeva;Christoph Globisch;Michael Wiese

Frequent Co-Authors

Martin Michaelis
Martin Michaelis University of Kent
Matthias U. Kassack
Matthias U. Kassack Heinrich Heine University Düsseldorf
Jindrich Cinatl
Jindrich Cinatl Goethe University Frankfurt
Christa E. Müller
Christa E. Müller University of Bonn
Gabriele M. König
Gabriele M. König University of Bonn
Michael Gütschow
Michael Gütschow University of Bonn
Günther Schmalzing
Günther Schmalzing RWTH Aachen University
Jean-Marie Boeynaems
Jean-Marie Boeynaems Université Libre de Bruxelles
Anthony D. Wright
Anthony D. Wright University of Bonn
Boris Fehse
Boris Fehse Universität Hamburg

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