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Ahcène Boumendjel

Ahcène Boumendjel

D-Index & Metrics

Chemistry

D-Index
45
Citations
6467
World Ranking
16560
National Ranking
723

Overview

Ahcène Boumendjel is affiliated with Grenoble Alpes University in France and contributes extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, pharmacology, oncology, materials chemistry, and biochemistry.

The scientist's main topics of work include:

  • Drug Transport and Resistance Mechanisms
  • Phytochemicals and Antioxidant Activities
  • Synthesis of Organic Compounds
  • Computational Drug Discovery Methods
  • HIV/AIDS drug development and treatment
  • Cancer therapeutics and mechanisms
  • Trace Elements in Health

Ahcène Boumendjel has published in several frequent venues, demonstrating a broad engagement in medicinal chemistry and molecular studies. These venues include:

  • European Journal of Medicinal Chemistry (8 publications)
  • Molecules (4 publications)
  • Future Medicinal Chemistry (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • The Cambridge Structural Database (3 publications)

Recent published papers by Boumendjel and colleagues cover a range of topics related to drug mechanisms, cancer therapeutics, and molecular transport. Examples include:

  • Focus on the high therapeutic potentials of quercetin and its derivatives, 2022, Phytomedicine Plus
  • Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter, 2022, Science Advances
  • Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1, 2020, Scientific Reports
  • Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance, 2020, Molecules
  • Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery, 2022, Pharmaceutics

The scientist frequently collaborates with a consistent group of co-authors, indicating sustained research partnerships. Key co-author names include:

  • Pierre Falson (15 collaborations)
  • Basile Pérès (10 collaborations)
  • Vincent Chaptal (7 collaborations)
  • Kim-Anh Nguyen (6 collaborations)
  • Christian Philouze (6 collaborations)

Best Publications

  • Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

    A. Di Pietro;G. Conseil;J.M. Pérez-Victoria;G. Dayan

  • Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.

    Ahcène Boumendjel;Julien Boccard;Pierre-Alain Carrupt;Edwige Nicolle

  • Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

    Gergely Szakács;Matthew D. Hall;Michael M. Gottesman;Ahcène Boumendjel

  • Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance

    Ahcène Boumendjel;Attilio Di Pietro;Charles Dumontet;Denis Barron

  • Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.

    Sabrina Okombi;Delphine Rival;Sébastien Bonnet;Anne-Marie Mariotte

  • Aurones: a subclass of flavones with promising biological potential.

    Ahcene Boumendjel

  • Halogenated Chalcones with High-Affinity Binding to P-Glycoprotein: Potential Modulators of Multidrug Resistance

    F. Bois;C. Beney;A. Boumendjel;A.-M. Mariotte

  • Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Flavonoid Derivatives and Analogues

    Mohamed Hadjeri;Magali Barbier;Xavier Ronot;Anne-Marie Mariotte

  • Recent advances in the medicinal chemistry of aurones.

    Haudecoeur R;Boumendjel A

  • Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase

    Sabrina Okombi;Delphine Rival;Sébastien Bonnet;Anne-Marie Mariotte

  • Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

    Romain Haudecoeur;Abdelhakim Ahmed-Belkacem;Wei Yi;Antoine Fortuné

  • Flavonoids as promising lead compounds in type 2 diabetes mellitus: molecules of interest and structure-activity relationship.

    E. Nicolle;F. Souard;P. Faure;A. Boumendjel

  • Chalcones Derivatives Acting as Cell Cycle Blockers: Potential Anti Cancer Drugs?

    Ahcene Boumendjel;Xavier Ronot;Jean Boutonnat

  • Flavonoids as RTK inhibitors and potential anticancer agents

    Florence Teillet;Ahcene Boumendjel;Jean Boutonnat;Xavier Ronot

  • Flavonoide esters and their use notably in cosmetics

    Eric Perrier;Anne-Marie Mariotte;Ahcene Boumendjel;Delphine Bresson-Rival

  • Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2

    Ahcene Boumendjel;Sira Macalou;Abdelhakim Ahmed-Belkacem;Madeleine Blanc

  • Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones.

    Mohamed Hadjeri;Eva-Laure Peiller;Chantal Beney;Nabajyoti Deka

  • Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance.

    Frédéric Bois;Ahcène Boumendjel;Anne-Marie Mariotte;Gwenaëlle Conseil

  • Occurrences, biosynthesis and properties of aurones as high-end evolutionary products.

    Benjamin Boucherle;Marine Peuchmaur;Ahcène Boumendjel;Romain Haudecoeur

  • A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

    Ahcene Boumendjel;Anne McLeer-Florin;Pierre Champelovier;Diane Allegro

  • Investigation of Chalcones as Selective Inhibitors of the Breast Cancer Resistance Protein: Critical Role of Methoxylation in both Inhibition Potency and Cytotoxicity

    Glaucio Valdameri;Glaucio Valdameri;Charlotte Gauthier;Raphaël Terreux;Rémy Kachadourian

  • Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (syn. Waltheria americana): a review.

    F. Zongo;C. Ribuot;A. Boumendjel;I. Guissou

Frequent Co-Authors

Attilio Di Pietro
Attilio Di Pietro University of Lyon System
Michel De Waard
Michel De Waard University of Nantes
Pierre-Alain Carrupt
Pierre-Alain Carrupt École Polytechnique Fédérale de Lausanne
Jean-Luc Wolfender
Jean-Luc Wolfender University of Geneva
Brian J. Day
Brian J. Day National Jewish Health
Luigi Bubacco
Luigi Bubacco University of Padua
Rajendra Prasad
Rajendra Prasad Amity University
Denis Barron
Denis Barron Nestlé (Switzerland)
Antoine Depaulis
Antoine Depaulis Grenoble Alpes University

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