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Shin-ichi Muramatsu

Shin-ichi Muramatsu

D-Index & Metrics

Neuroscience

D-Index
50
Citations
10071
World Ranking
5703
National Ranking
181

Overview

Shin-ichi Muramatsu is affiliated with Jichi Medical University in Japan and has a research portfolio spanning Neuroscience, Biochemistry, Genetics and Molecular Biology, and Medicine. Their scientific output encompasses publications in main fields such as Neuroscience with 67 papers, Biochemistry, Genetics and Molecular Biology totaling 54 publications, and Medicine with 53 contributions.

The scientist's work delves particularly into subfields including Cellular and Molecular Neuroscience (36 publications), Molecular Biology (29), Genetics (21), Cognitive Neuroscience (15), and Neurology (12). This diversity highlights a focus on both fundamental and applied aspects of brain and molecular function.

Themes addressed in their research cover several main topics: Neuroscience and Neuropharmacology Research (36 publications), Virus-based Gene Therapy Research (26), Memory and Neural Mechanisms (14), Sleep and Wakefulness Research (10), Neurotransmitter Receptor Influence on Behavior (10), Traditional Chinese Medicine Studies (10), and Neurogenetic and Muscular Disorders Research (8).

Frequent co-authors collaborating with Muramatsu include Atsumi Nitta (20 collaborations), Naotaka Izuo (15), Takashi Asano (12), Kaoru Inokuchi (7), and Hajime Miyanishi (6), indicating ongoing research partnerships within related biomedical fields.

The scientist's work has appeared in various publication venues, notably:

  • Proceedings for Annual Meeting of The Japanese Pharmacological Society (9 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5)
  • The International Journal of Neuropsychopharmacology (5)
  • Nature Communications (4)
  • Neurochemical Research (3)

Recent papers include:

  • Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency, 2021, Molecular Therapy
  • YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology, 2020, Nature Communications
  • An ultra-stable cytoplasmic antibody engineered for in vivo applications, 2020, Nature Communications
  • Gene Therapy in a Mouse Model of Niemann-Pick Disease Type C1, 2020, Human Gene Therapy
  • Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease, 2021, EMBO Molecular Medicine

Additionally, Muramatsu has contributed to literature in environmental health, with a book published by Global environmental studies: Living in the Megacity: Towards Sustainable Urban Environments (2021).

Best Publications

  • Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

    Banafsheh Kadkhodaei;Takehito Ito;Eliza Joodmardi;Bengt Mattsson

  • A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.

    Shin-ichi Muramatsu;Ken-ichi Fujimoto;Seiya Kato;Hiroaki Mizukami

  • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

    Li-Jun Wang;Yan-Yan Lu;Shin-ichi Muramatsu;Kunihiko Ikeguchi

  • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain

    Nobuhisa Iwata;Hiroaki Mizukami;Keiro Shirotani;Yoshie Takaki

  • Gene therapy for aromatic L-amino acid decarboxylase deficiency.

    Wuh-Liang Hwu;Shin-ichi Muramatsu;Sheng-Hong Tseng;Kai-Yuan Tzen

  • Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease

    Yang Shen;Shin-Ichi Muramatsu;Kunihiko Ikeguchi;Ken-Ichi Fujimoto

  • Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.

    Masashi Tanaka;Harm-Jan Borgeld;Jin Zhang;Shin-ichi Muramatsu

  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

    Shin-Ichi Muramatsu;Ken-Ichi Fujimoto;Kunihiko Ikeguchi;Nami Shizuma

  • Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

    Akihiko Noguchi;Satoko Matsumura;Mari Dezawa;Mari Dezawa;Mari Tada

  • Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

    L Wang;S Muramatsu;Y Lu;K Ikeguchi

  • Synapse-specific representation of the identity of overlapping memory engrams

    Kareem Abdou;Mohammad Shehata;Kiriko Choko;Hirofumi Nishizono

  • Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.

    Masaki Wakamatsu;Aiko Ishii;Shingo Iwata;Junko Sakagami

  • Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors

    Atsushi Handa;Shin-ichi Muramatsu;Jianming Qiu;Hiroaki Mizukami

  • Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

    Wataru Kakegawa;Nikolaos Mitakidis;Eriko Miura;Manabu Abe

  • Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease.

    Yoshihide Sehara;Ken-Ichi Fujimoto;Kunihiko Ikeguchi;Yuko Katakai

  • Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

    Takayuki Ohnishi;Takayuki Ohnishi;Masako Yanazawa;Tomoya Sasahara;Tomoya Sasahara;Yasuki Kitamura

  • Efficacy and safety of AAV2 gene therapy in children with aromatic L-amino acid decarboxylase deficiency: an open-label, phase 1/2 trial.

    Yin-Hsiu Chien;Ni-Chung Lee;Sheng-Hong Tseng;Chun-Hwei Tai

  • Long-term efficacy and safety of eladocageneexuparvovec in patients with AADC deficiency

    Chun-Hwei Tai;Ni-Chung Lee;Yin-Hsiu Chien;Barry J. Byrne

  • Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.

    Yuhe Liu;Takashi Okada;Kianoush Sheykholeslami;Kuniko Shimazaki

  • Gene therapy improves motor and mental function of aromatic l-amino acid decarboxylase deficiency.

    Karin Kojima;Takeshi Nakajima;Naoyuki Taga;Akihiko Miyauchi

  • Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

    Nobuhisa Iwata;Nobuhisa Iwata;Misaki Sekiguchi;Yoshino Hattori;Akane Takahashi

  • Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.

    Masahiro Maruyama;Makoto Higuchi;Makoto Higuchi;Yoshie Takaki;Yukio Matsuba

Frequent Co-Authors

Atsumi Nitta
Atsumi Nitta University of Toyama
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Kaoru Inokuchi
Kaoru Inokuchi University of Toyama
Hirokazu Hirai
Hirokazu Hirai Gunma University
Hideo Tsukada
Hideo Tsukada Hamamatsu Photonics (Japan)
Mitsuhiro Kato
Mitsuhiro Kato Showa University
Gen Sobue
Gen Sobue Aichi Medical University
Makoto Naoi
Makoto Naoi Nagoya Institute of Technology
Kevin E. Brown
Kevin E. Brown Public Health England
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University

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