World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
14999
World Ranking
12393
National Ranking
848

Overview

Hiroshi Ichinose is affiliated with the Tokyo Institute of Technology in Japan, contributing extensively to research in medicine, neuroscience, and biochemistry, genetics, and molecular biology. Their research spans several subfields, including cellular and molecular neuroscience, molecular biology, neurology, nutrition and dietetics, and physiology.

Their recent publications reflect a focus on neurobiology, immune response, and vascular health, with papers addressing diverse topics such as neurotoxicity, inflammation, and dopamine biosynthesis. Notable recent works include:

  • Exposure to acrylamide decreases noradrenergic axons in rat brain, 2020, NeuroToxicology
  • Neutrophil-derived catecholamines mediate negative stress effects on bone, 2023, Nature Communications
  • Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice, 2022, Frontiers in Pharmacology
  • Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways, 2021, Journal of Biological Chemistry
  • Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis, 2021, Frontiers in Immunology

Their frequent co-authors include Satoshi Hara, Shuhei Niiyama, Yasuyuki Kakihana, Chiho Sumi-Ichinose, and Chinatsu Kamikokuryo, indicating ongoing collaborative efforts within the scientific community.

Ichinose's research has been published in several prominent venues, with multiple contributions to Biochemical and Biophysical Research Communications, The Journal of Biochemistry, Research Square, Proceedings for Annual Meeting of The Japanese Pharmacological Society, and Nature Communications.

Among the central research themes in their work are Vitamin C and antioxidants research, sepsis diagnosis and treatment, Vitamin K research studies, COVID-19 clinical research studies, neuroscience and neuropharmacology research, stress responses and cortisol, and studies involving S100 proteins and annexins. This range highlights a multidisciplinary approach integrating biochemical, molecular, and clinical perspectives.

Best Publications

  • Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

    Hiroshi Ichinose;Tamae Ohye;Ei ichi Takahashi;Ei ichi Takahashi;Naohiko Seki

  • A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

    B Le Douarin;A L Nielsen;J M Garnier;H Ichinose

  • Changes in cytokines and neurotrophins in Parkinson's disease.

    T Nagatsu;M Mogi;H Ichinose;A Togari

  • Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

    Hiroshi Kawasaki;Hirofumi Suemori;Kenji Mizuseki;Kiichi Watanabe

  • Patrolling monocytes control tumor metastasis to the lung

    Richard N. Hanna;Caglar Cekic;Duygu Sag;Robert Tacke

  • Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.

    Makio Mogi;Akifumi Togari;Tomoyoshi Kondo;Yoshikuni Mizuno

  • Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

    Banafsheh Kadkhodaei;Takehito Ito;Eliza Joodmardi;Bengt Mattsson

  • Cytokines in Parkinson’s Disease

    T. Nagatsu;M. Mogi;H. Ichinose;A. Togari

  • Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

    Takashi Sekiya;Ikkou Kashiwagi;Rei Yoshida;Tomohiro Fukaya

  • Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain.

    M. Mogi;A. Togari;T. Kondo;Y. Mizuno

  • A quantitative-trait analysis of human plasma-dopamine β-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus

    Cyrus P. Zabetian;George M. Anderson;Sarah G. Buxbaum;Robert C. Elston

  • Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

    Nobuyuki Yamasaki;Motoko Maekawa;Katsunori Kobayashi;Yasushi Kajii

  • Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease

    Yang Shen;Shin-Ichi Muramatsu;Kunihiko Ikeguchi;Ken-Ichi Fujimoto

  • The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.

    Takashi Sekiya;Ikkou Kashiwagi;Naoko Inoue;Rimpei Morita

  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

    Shin-Ichi Muramatsu;Ken-Ichi Fujimoto;Kunihiko Ikeguchi;Nami Shizuma

  • Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2

    Hiroshi Ichinose;Jean-Marie Garnier;Pierre Chambon;Régine Losson

  • Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

    L Wang;S Muramatsu;Y Lu;K Ikeguchi

  • SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells.

    Chiho Sumi-Ichinose;Hiroshi Ichinose;Daniel Metzger;Pierre Chambon

  • Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.

    Norio Kaneda;Kazuto Kobayashi;Hiroshi Ichinose;Fumio Kishi

  • Behavioral Recovery in 6-Hydroxydopamine-Lesioned Rats by Cotransduction of Striatum with Tyrosine Hydroxylase and Aromatic l-Amino Acid Decarboxylase Genes Using Two Separate Adeno-Associated Virus Vectors

    Dong-Shen Fan;Matsuo Ogawa;Ken-Ichi Fujimoto;Kunihiko Ikeguchi

Frequent Co-Authors

Toshiharu Nagatsu
Toshiharu Nagatsu Fujita Health University
Shin-ichi Muramatsu
Shin-ichi Muramatsu Jichi Medical University
Kazuto Kobayashi
Kazuto Kobayashi Fukushima Medical University
Ikuko Nagatsu
Ikuko Nagatsu Fujita Health University
Keiya Ozawa
Keiya Ozawa Jichi Medical University
Daniel Metzger
Daniel Metzger Institute of Genetics and Molecular and Cellular Biology
Makoto Naoi
Makoto Naoi Nagoya Institute of Technology
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Yukio Shimosato
Yukio Shimosato National Cancer Research Institute, UK
Koiti Titani
Koiti Titani Fujita Health University

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