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Makoto Naoi

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Neuroscience 69 2683 2452 67 63 284 13161

Makoto Naoi publications per year

The chart shows the history of publications by Makoto Naoi between 1964 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Makoto Naoi published across 62 years, from 1964 to 2025, averaging 4.8 papers a year. Output peaked at 21 publications in 1993. 5 of the 298 publications appeared in the last two years.

No. of publications
5 10 15 20
Bar chart. Horizontal axis: year, 1964 to 2025. Vertical axis: number of publications, 0 to 21. Peak 21 publications in 1993. 1964: 1 publication 1965: 0 publications 1966: 4 publications 1967: 2 publications 1968: 0 publications 1969: 3 publications 1970: 2 publications 1971: 1 publication 1972: 0 publications 1973: 1 publication 1974: 2 publications 1975: 0 publications 1976: 1 publication 1977: 1 publication 1978: 2 publications 1979: 2 publications 1980: 1 publication 1981: 2 publications 1982: 2 publications 1983: 0 publications 1984: 3 publications 1985: 2 publications 1986: 5 publications 1987: 13 publications 1988: 15 publications 1989: 10 publications 1990: 9 publications 1991: 8 publications 1992: 9 publications 1993: 21 publications 1994: 13 publications 1995: 13 publications 1996: 11 publications 1997: 8 publications 1998: 13 publications 1999: 7 publications 2000: 10 publications 2001: 6 publications 2002: 20 publications 2003: 3 publications 2004: 6 publications 2005: 4 publications 2006: 8 publications 2007: 2 publications 2008: 4 publications 2009: 4 publications 2010: 3 publications 2011: 1 publication 2012: 4 publications 2013: 3 publications 2014: 2 publications 2015: 1 publication 2016: 4 publications 2017: 3 publications 2018: 3 publications 2019: 2 publications 2020: 3 publications 2021: 2 publications 2022: 6 publications 2023: 2 publications 2024: 4 publications 2025: 1 publication
1964 2025

298 publications in total across all disciplines

View publications per year as a table
Makoto Naoi: publications per year, 1964 to 2025
Year Publications
1964 1
1965 0
1966 4
1967 2
1968 0
1969 3
1970 2
1971 1
1972 0
1973 1
1974 2
1975 0
1976 1
1977 1
1978 2
1979 2
1980 1
1981 2
1982 2
1983 0
1984 3
1985 2
1986 5
1987 13
1988 15
1989 10
1990 9
1991 8
1992 9
1993 21
1994 13
1995 13
1996 11
1997 8
1998 13
1999 7
2000 10
2001 6
2002 20
2003 3
2004 6
2005 4
2006 8
2007 2
2008 4
2009 4
2010 3
2011 1
2012 4
2013 3
2014 2
2015 1
2016 4
2017 3
2018 3
2019 2
2020 3
2021 2
2022 6
2023 2
2024 4
2025 1
Total 298
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Makoto Naoi publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where Makoto Naoi sits on this spectrum.

No. of scientists
100 200 300 400 500
Bar chart with 86 bars. Horizontal axis: publications, 38–47 to 887+. Vertical axis: number of scientists, 0 to 539. Most scientists, 539, have 98–107 publications. The last bar groups every scientist with 887 publications or more. The highlighted bar, 278–287 publications, is where this scientist sits. 38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientist 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38–47 publications 887+

This scientist: 284 publications — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

View publications distribution as a table
Number of Neuroscience scientists by publication count, Research.com 2026 ranking edition. Based on 9,597 ranked scientists.
Publications Scientists This scientist
38–47 18
48–57 79
58–67 193
68–77 323
78–87 406
88–97 452
98–107 539
108–117 505
118–127 522
128–137 469
138–147 456
148–157 459
158–167 397
168–177 383
178–187 350
188–197 302
198–207 306
208–217 262
218–227 242
228–237 220
238–247 203
248–257 174
258–267 176
268–277 175
278–287 125 284
288–297 116
298–307 127
308–317 128
318–327 99
328–337 89
338–347 78
348–357 96
358–367 66
368–377 59
378–387 65
388–397 54
398–407 48
408–417 49
418–427 34
428–437 31
438–447 30
448–457 31
458–467 36
468–477 40
478–487 35
488–497 30
498–507 23
508–517 26
518–527 20
528–537 23
538–547 20
548–557 20
558–567 17
568–577 14
578–587 20
588–597 20
598–607 19
608–617 18
618–627 17
628–637 11
638–647 11
648–657 11
658–667 8
668–677 7
678–687 11
688–697 10
698–707 4
708–717 6
718–727 5
728–737 5
738–747 9
748–757 9
758–767 3
768–777 7
778–787 7
788–797 6
798–807 2
808–817 2
818–827 7
828–837 0
838–847 9
848–857 3
858–867 1
868–877 3
878–886 6
887+ 100
Download as CSV

Makoto Naoi D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where Makoto Naoi sits on this spectrum.

No. of scientists
100 200 300 400 500
Bar chart with 68 bars. Horizontal axis: D-Index, 30–31 to 163+. Vertical axis: number of scientists, 0 to 512. Most scientists, 512, have 46–47 D-Index. The last bar groups every scientist with 163 D-Index or more. The highlighted bar, 68–69 D-Index, is where this scientist sits. 30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30–31 D-Index 163+

This scientist: 69 D-Index — 73rd percentile

73% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

View D-Index distribution as a table
Number of Neuroscience scientists by D-index, Research.com 2026 ranking edition. Based on 9,597 ranked scientists.
D-Index Scientists This scientist
30–31 42
32–33 172
34–35 296
36–37 435
38–39 459
40–41 456
42–43 467
44–45 478
46–47 512
48–49 435
50–51 425
52–53 418
54–55 392
56–57 357
58–59 334
60–61 328
62–63 260
64–65 278
66–67 239
68–69 250 69
70–71 210
72–73 200
74–75 189
76–77 170
78–79 146
80–81 113
82–83 126
84–85 100
86–87 84
88–89 99
90–91 84
92–93 85
94–95 72
96–97 76
98–99 45
100–101 49
102–103 43
104–105 32
106–107 45
108–109 50
110–111 32
112–113 39
114–115 32
116–117 29
118–119 27
120–121 19
122–123 23
124–125 27
126–127 16
128–129 24
130–131 13
132–133 21
134–135 17
136–137 14
138–139 15
140–141 10
142–143 10
144–145 13
146–147 9
148–149 8
150–151 6
152–153 6
154–155 7
156–157 7
158–159 10
160–161 4
162 8
163+ 100
Download as CSV

Overview

Makoto Naoi is affiliated with the Nagoya Institute of Technology in Japan and has contributed extensively to the fields of Medicine and Neuroscience, focusing particularly on neurology and cellular and molecular neuroscience. Their research covers physiological aspects as well as complementary and alternative medicine approaches related to neurological diseases.

The scientist's work deeply investigates mechanisms and treatments for Parkinson's disease, with a significant emphasis on mitochondrial function, apoptosis, and neurotransmitter systems. Their studies also cover Alzheimer's disease research, neurodegenerative diseases involving cholinesterase, and the role of bioactive compounds from medicinal plants.

Makoto Naoi has published in several notable journals, with frequent contributions to:

  • Journal of Neural Transmission
  • International Journal of Molecular Sciences
  • Journal of Instrumentation
  • SSRN Electronic Journal

Prominent topics addressed in their research include:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurotransmitter Receptor Influence on Behavior
  • Alzheimer's disease research and treatments
  • Ginkgo biloba and Cashew Applications
  • Cholinesterase and Neurodegenerative Diseases
  • Tryptophan and brain disorders
  • Medicinal Plants and Bioactive Compounds

Their main research interests revolve around the pathology and treatment of neurodegenerative disorders, mitochondrial homeostasis, and the modulation of monoamine oxidases, particularly in relation to synucleinopathies and psychiatric diseases. The work also addresses the interactions of dopamine, α-synuclein, and mitochondrial genes in Parkinson's disease.

Notable recent publications include:

  • "Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease" (2020, Journal of Neural Transmission)
  • "Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies" (2022, International Journal of Molecular Sciences)
  • "Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors" (2021, Journal of Neural Transmission)
  • "Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases" (2025, International Journal of Molecular Sciences)
  • "Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease" (2024, Journal of Neural Transmission)

Frequent collaborators in Naoi's research include Wakako Maruyama, Masayo Shamoto-Nagai, Peter Riederer, Yuqiu Wu, and K. Ogawa. These partnerships have supported investigations primarily into the molecular and biochemical aspects of neurodegenerative diseases.

Best Publications

  • Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running

    Satoshi Hattori;Makoto Naoi;Hitoo Nishino

  • Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.

    Masashi Tanaka;Harm-Jan Borgeld;Jin Zhang;Shin-ichi Muramatsu

  • Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.

    Wakako Maruyama;Yukihiro Akao;Moussa B. H. Youdim;Bruce A. Davis

  • Hydroxyl radical formation in diabetic rats induced by streptozotocin.

    Tetsuo Ohkuwa;Yuzo Sato;Makoto Naoi

  • Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.

    Yukihiro Akao;Wakako Maruyama;Shigeomi Shimizu;Hong Yi

  • Neuroprotection by propargylamines in Parkinson's disease : suppression of apoptosis and induction of prosurvival genes

    Wakako Maruyama;Yukihiro Akao;Maria Chrisina Carrillo;Ken-ichi Kitani

  • Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

    Unknown

  • Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies

    Makoto Naoi;Wakako Maruyama;Philippe Dostert;Yoshio Hashizume

  • An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells.

    Yukihiro Akao;Wakako Maruyama;Hong Yi;Masayo Shamoto-Nagai

  • A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.

    Makoto Naoi;Wakako Maruyama;Philippe Dostert;Kohfuku Kohda

  • Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains

    Makoto Naoi;Wakako Maruyama;Georgy M Nagy

  • Antiapoptotic Properties of Rasagiline, N-Propargylamine-1(R)-aminoindan, and Its Optical (S)-Isomer, TV1022

    Wakako Maruyama;Moussa B.H. Youdim;Makoto Naoi

  • N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor

    Wakako Maruyama;Atusmi Nitta;Atusmi Nitta;Masayo Shamoto-Nagai;Yoko Hirata

  • Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.

    Kentaro Oh-hashi;Wakako Maruyama;Hong Yi;Tsutomu Takahashi

  • In parkinsonian substantia nigra, α-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity

    M. Shamoto-Nagai;W. Maruyama;Y. Hashizume;M. Yoshida

  • A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion.

    Makoto Naoi;Sadao Matsuura;Tsutomu Takahashi;Toshiharu Nagatsu

  • Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.

    Wakako Maruyama;Marta Weinstock;Moussa B.H Youdim;Masayo Nagai

  • The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells.

    W. Maruyama;T. Takahashi;M. Youdim;M. Naoi

  • A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid.

    Wakako Maruyama;Takashi Abe;Hideo Tohgi;Philippe Dostert

  • N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.

    Wakako Maruyama;Daiichiro Nakahara;Miyuki Ota;Tsutomu Takahashi

  • An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells.

    Wakako Maruyama;Makoto Naoi;Toshio Kasamatsu;Yoshio Hashizume

  • Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.

    T. Yamamoto;W. Maruyama;Y. Kato;H. Yi

Frequent Co-Authors

Toshiharu Nagatsu
Toshiharu Nagatsu Fujita Health University
Kunio Yagi
Kunio Yagi Nagoya University
Yulin Deng
Yulin Deng Georgia Institute of Technology
Yukihiro Akao
Yukihiro Akao Gifu University
Hiroshi Ichinose
Hiroshi Ichinose Tokyo Institute of Technology
Moussa B.H. Youdim
Moussa B.H. Youdim Technion – Israel Institute of Technology
Kazuyoshi Watanabe
Kazuyoshi Watanabe Nagoya University
Takashi Sugimura
Takashi Sugimura National Cancer Centre
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Yoshikuni Mizuno
Yoshikuni Mizuno Juntendo University

External Links

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Best Scientists Citing Makoto Naoi

Moussa B.H. Youdim

Moussa B.H. Youdim

Technion – Israel Institute of Technology

Publications: 94

Tamar Amit

Tamar Amit

Technion – Israel Institute of Technology

Publications: 53

Toshiharu Nagatsu

Toshiharu Nagatsu

Fujita Health University

Publications: 35

Ferenc Fülöp

Ferenc Fülöp

University of Szeged

Publications: 28

Yulin Deng

Yulin Deng

Georgia Institute of Technology

Publications: 27

Peter Riederer

Peter Riederer

University of Würzburg

Publications: 25

Kunio Yagi

Kunio Yagi

Nagoya University

Publications: 21

Yukihiro Akao

Yukihiro Akao

Gifu University

Publications: 20

Carlos T. Moraes

Carlos T. Moraes

University of Miami

Publications: 19

Anthony H.V. Schapira

Anthony H.V. Schapira

University College London

Publications: 15

Toshihiko Osawa

Toshihiko Osawa

Nagoya University

Publications: 15

Shigeru Ohta

Shigeru Ohta

Hiroshima University

Publications: 15

Peter Jenner

Peter Jenner

King's College London

Publications: 14

Yoshikuni Mizuno

Yoshikuni Mizuno

Juntendo University

Publications: 14

Yousef Tizabi

Yousef Tizabi

Howard University

Publications: 13

Michal Minczuk

Michal Minczuk

University of Cambridge

Publications: 13

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