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Neuroscience

D-Index
69
Citations
13161
World Ranking
2683
National Ranking
67

Overview

Makoto Naoi is affiliated with the Nagoya Institute of Technology in Japan and has contributed extensively to the fields of Medicine and Neuroscience, focusing particularly on neurology and cellular and molecular neuroscience. Their research covers physiological aspects as well as complementary and alternative medicine approaches related to neurological diseases.

The scientist's work deeply investigates mechanisms and treatments for Parkinson's disease, with a significant emphasis on mitochondrial function, apoptosis, and neurotransmitter systems. Their studies also cover Alzheimer's disease research, neurodegenerative diseases involving cholinesterase, and the role of bioactive compounds from medicinal plants.

Makoto Naoi has published in several notable journals, with frequent contributions to:

  • Journal of Neural Transmission
  • International Journal of Molecular Sciences
  • Journal of Instrumentation
  • SSRN Electronic Journal

Prominent topics addressed in their research include:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurotransmitter Receptor Influence on Behavior
  • Alzheimer's disease research and treatments
  • Ginkgo biloba and Cashew Applications
  • Cholinesterase and Neurodegenerative Diseases
  • Tryptophan and brain disorders
  • Medicinal Plants and Bioactive Compounds

Their main research interests revolve around the pathology and treatment of neurodegenerative disorders, mitochondrial homeostasis, and the modulation of monoamine oxidases, particularly in relation to synucleinopathies and psychiatric diseases. The work also addresses the interactions of dopamine, α-synuclein, and mitochondrial genes in Parkinson's disease.

Notable recent publications include:

  • "Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease" (2020, Journal of Neural Transmission)
  • "Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies" (2022, International Journal of Molecular Sciences)
  • "Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors" (2021, Journal of Neural Transmission)
  • "Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases" (2025, International Journal of Molecular Sciences)
  • "Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease" (2024, Journal of Neural Transmission)

Frequent collaborators in Naoi's research include Wakako Maruyama, Masayo Shamoto-Nagai, Peter Riederer, Yuqiu Wu, and K. Ogawa. These partnerships have supported investigations primarily into the molecular and biochemical aspects of neurodegenerative diseases.

Best Publications

  • Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running

    Satoshi Hattori;Makoto Naoi;Hitoo Nishino

  • Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.

    Masashi Tanaka;Harm-Jan Borgeld;Jin Zhang;Shin-ichi Muramatsu

  • Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.

    Wakako Maruyama;Yukihiro Akao;Moussa B. H. Youdim;Bruce A. Davis

  • Hydroxyl radical formation in diabetic rats induced by streptozotocin.

    Tetsuo Ohkuwa;Yuzo Sato;Makoto Naoi

  • Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.

    Yukihiro Akao;Wakako Maruyama;Shigeomi Shimizu;Hong Yi

  • Neuroprotection by propargylamines in Parkinson's disease : suppression of apoptosis and induction of prosurvival genes

    Wakako Maruyama;Yukihiro Akao;Maria Chrisina Carrillo;Ken-ichi Kitani

  • Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

    Unknown

  • Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies

    Makoto Naoi;Wakako Maruyama;Philippe Dostert;Yoshio Hashizume

  • An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells.

    Yukihiro Akao;Wakako Maruyama;Hong Yi;Masayo Shamoto-Nagai

  • A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.

    Makoto Naoi;Wakako Maruyama;Philippe Dostert;Kohfuku Kohda

  • Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains

    Makoto Naoi;Wakako Maruyama;Georgy M Nagy

  • Antiapoptotic Properties of Rasagiline, N-Propargylamine-1(R)-aminoindan, and Its Optical (S)-Isomer, TV1022

    Wakako Maruyama;Moussa B.H. Youdim;Makoto Naoi

  • N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor

    Wakako Maruyama;Atusmi Nitta;Atusmi Nitta;Masayo Shamoto-Nagai;Yoko Hirata

  • Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.

    Kentaro Oh-hashi;Wakako Maruyama;Hong Yi;Tsutomu Takahashi

  • In parkinsonian substantia nigra, α-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity

    M. Shamoto-Nagai;W. Maruyama;Y. Hashizume;M. Yoshida

  • A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion.

    Makoto Naoi;Sadao Matsuura;Tsutomu Takahashi;Toshiharu Nagatsu

  • Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.

    Wakako Maruyama;Marta Weinstock;Moussa B.H Youdim;Masayo Nagai

  • The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells.

    W. Maruyama;T. Takahashi;M. Youdim;M. Naoi

  • A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid.

    Wakako Maruyama;Takashi Abe;Hideo Tohgi;Philippe Dostert

  • N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.

    Wakako Maruyama;Daiichiro Nakahara;Miyuki Ota;Tsutomu Takahashi

  • An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells.

    Wakako Maruyama;Makoto Naoi;Toshio Kasamatsu;Yoshio Hashizume

  • Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.

    T. Yamamoto;W. Maruyama;Y. Kato;H. Yi

Frequent Co-Authors

Yulin Deng
Yulin Deng Georgia Institute of Technology
Moussa B.H. Youdim
Moussa B.H. Youdim Technion – Israel Institute of Technology
Kazuyoshi Watanabe
Kazuyoshi Watanabe Nagoya University
Shin-ichi Muramatsu
Shin-ichi Muramatsu Jichi Medical University
Stefanie N. Vogel
Stefanie N. Vogel University of Maryland, Baltimore
Kuan-Teh Jeang
Kuan-Teh Jeang National Institutes of Health
Takeo Yoshikawa
Takeo Yoshikawa RIKEN Center for Brain Science
Hideo Tohgi
Hideo Tohgi Iwate Medical University
Masashi Tanaka
Masashi Tanaka Juntendo University
Alan A. Boulton
Alan A. Boulton University of Saskatchewan

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