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Chemistry

D-Index
51
Citations
7263
World Ranking
14177
National Ranking
1098

Overview

Tohru Dairi is a researcher affiliated with Hokkaido University in Japan, specializing in the areas of biochemistry, genetics, and molecular biology. Their work spans multiple subfields, notably molecular biology and pharmacology, with additional contributions to plant science, nutrition and dietetics, and oncology. The main focus of their research lies in microbial natural products and biosynthesis, microbial metabolic engineering and bioproduction, genomics and phylogenetic studies, RNA and protein synthesis mechanisms, peptidase inhibition and analysis, as well as fungal biology and metal-catalyzed oxygenation mechanisms.

Dairi has contributed to numerous publications in a range of peer-reviewed journals, with frequent appearances in venues such as Bioscience Biotechnology and Biochemistry, Journal of Bioscience and Bioengineering, Nature Communications, The Journal of Antibiotics, and Journal of Agricultural and Food Chemistry.

Notable recent papers include:

  • Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes (2021), published in Angewandte Chemie International Edition
  • High Production of Ergothioneine in Escherichia coli using the Sulfoxide Synthase from Methylobacterium strains (2020), published in Journal of Agricultural and Food Chemistry
  • Recent advances in functional analysis of polyunsaturated fatty acid synthases (2020), published in Current Opinion in Chemical Biology
  • Identification of the peptide epimerase MslH responsible for d-amino acid introduction at the C-terminus of ribosomal peptides (2020), published in Chemical Science
  • First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria (2022), published in Communications Biology

Collaborations form a significant part of Dairi's scientific output. Frequent co-authors include Yasushi Ogasawara, Chitose Maruyama, Yoshimitsu Hamano, Yasuharu Satoh, and Takeshi Tsunoda.

Best Publications

  • An alternative menaquinone biosynthetic pathway operating in microorganisms.

    Tomoshige Hiratsuka;Kazuo Furihata;Jun Ishikawa;Haruyuki Yamashita

  • Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi

    Tomonobu Toyomasu;Mai Tsukahara;Akane Kaneko;Rie Niida

  • Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.

    Koichi Tagami;Chengwei Liu;Atsushi Minami;Motoyoshi Noike

  • Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol from 2-C-methyl-d-erythritol 4-phosphate by 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway

    Tomohisa Kuzuyama;Motoki Takagi;Kazuhide Kaneda;Tohru Dairi

  • Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase

    Tomohisa Kuzuyama;Motoki Takagi;Kazuhide Kaneda;Hiroyuki Watanabe

  • Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.

    Tohru Dairi;Tetsuo Nakano;Kazuo Aisaka;Ryoichl Katsumata

  • Gene cloning, biochemical characterization and physiological role of a thermostable low‐specificity L‐threonine aldolase from Escherichia coli

    Ji-Quan Liu;Tohru Dairi;Nobuya Itoh;Michihiko Kataoka

  • Chiral alcohol production by NADH-dependent phenylacetaldehyde reductase coupled with in situ regeneration of NADH.

    Nobuya Itoh;Michiko Matsuda;Mariko Mabuchi;Tohru Dairi

  • Biosynthesis of a Natural Polyketide-Isoprenoid Hybrid Compound, Furaquinocin A: Identification and Heterologous Expression of the Gene Cluster

    Takashi Kawasaki;Yutaka Hayashi;Tomohisa Kuzuyama;Kazuo Furihata

  • Studies on the nonmevalonate pathway: formation of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol

    Motoki Takagi;Tomohisa Kuzuyama;Kazuhide Kaneda;Hiroyuki Watanabe

  • Eubacterial Diterpene Cyclase Genes Essential for Production of the Isoprenoid Antibiotic Terpentecin

    Tohru Dairi;Yoshimitsu Hamano;Tomohisa Kuzuyama;Nobuya Itoh

  • fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

    Kia-Joo Puan;Hong Wang;Tohru Dairi;Tomohisa Kuzuyama

  • Functional Analysis of Eubacterial Diterpene Cyclases Responsible for Biosynthesis of a Diterpene Antibiotic, Terpentecin

    Yoshimitsu Hamano;Tomohisa Kuzuyama;Nobuya Itoh;Kazuo Furihata

  • Studies on Biosynthetic Genes and Enzymes of Isoprenoids Produced by Actinomycetes

    Tohru Dairi

  • Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.

    Shunji Takahashi;Atsushi Toyoda;Yasuyo Sekiyama;Hiroshi Takagi

  • Menaquinone Biosynthesis: Formation of aminofutalosine requires a unique radical SAM enzyme

    Nilkamal Mahanta;Dmytro Fedoseyenko;Tohru Dairi;Tadhg P. Begley

  • Biosynthetic Gene-Based Secondary Metabolite Screening: A New Diterpene, Methyl Phomopsenonate, from the Fungus Phomopsis amygdali

    Tomonobu Toyomasu;Akane Kaneko;Tetsuo Tokiwano;Yuya Kanno

  • Diversity of microbial threonine aldolases and their application

    Ji-Quan Liu;Tohru Dairi;Nobuya Itoh;Michihiko Kataoka

  • An Alkaline D-Stereospecific Endopeptidase with β-Lactamase Activity from Bacillus cereus

    Yasuhisa Asano;Hajime Ito;Tohru Dairi;Yasuo Kato

  • Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton

    Chiaki Nakano;Tomoo Okamura;Tsutomu Sato;Tohru Dairi

  • Alternative menaquinone biosynthetic pathway operating in microorganisms

    Tohru Dairi

Frequent Co-Authors

Tomohisa Kuzuyama
Tomohisa Kuzuyama University of Tokyo
Hideaki Oikawa
Hideaki Oikawa Hokkaido University
Sakayu Shimizu
Sakayu Shimizu Kyoto University
Kazuo Furihata
Kazuo Furihata University of Tokyo
Haruo Seto
Haruo Seto University of Tokyo
Yasuhisa Asano
Yasuhisa Asano Toyama Prefectural University
Toshikazu Oki
Toshikazu Oki Toyama Prefectural University
Katsuya Gomi
Katsuya Gomi Tohoku University
Tadhg P. Begley
Tadhg P. Begley Texas A&M University
Toshifumi Satoh
Toshifumi Satoh Hokkaido University

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