World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
74
Citations
19112
World Ranking
4709
National Ranking
1484

Biology and Biochemistry

D-Index
74
Citations
19044
World Ranking
5615
National Ranking
2665

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Tadhg P. Begley is affiliated with Texas A&M University in the United States. Their research spans various interconnected fields including molecular biology, biochemistry, renewable energy, sustainability, nutrition, and organic chemistry. The scientist's work is documented through multiple publications across prominent scientific venues and involves collaborations with numerous coauthors.

Key recent publications include:

  • Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H-Cluster, 2020, Journal of the American Chemical Society
  • Mechanistic Studies on CysS - A Vitamin B12-Dependent Radical SAM Methyltransferase Involved in the Biosynthesis of the tert-Butyl Group of Cystobactamid, 2020, Journal of the American Chemical Society
  • Structural basis for antibiotic action of the B1 antivitamin 2'-methoxy-thiamine, 2020, Nature Chemical Biology
  • Alkylcysteine Sulfoxide C-S Monooxygenase Uses a Flavin-Dependent Pummerer Rearrangement, 2023, Journal of the American Chemical Society
  • Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction, 2021, Biochemistry

The scientist has frequent coauthors including Anand Bachhawat, Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, and Roger Colbran, each contributing to multiple joint publications.

Publication venues where the scientist has contributed most often include:

  • Journal of Biological Chemistry (38 publications)
  • Journal of the American Chemical Society (5 publications)
  • Biochemistry (3 publications)
  • ACS Central Science (2 publications)
  • Nature Chemical Biology (1 publication)

Tadhg P. Begley's research topics cover biochemical and molecular research, biochemical acid research studies, metalloenzymes and iron-sulfur proteins, amino acid enzymes and metabolism, metabolism and genetic disorders, porphyrin metabolism and disorders, and click chemistry and applications.

Subfields of study include molecular biology, biochemistry, renewable energy, sustainability and environment, nutrition and dietetics, and organic chemistry.

The scientist was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes

    Ross Overbeek;Tadhg P. Begley;Ralph M. Butler;Jomuna Choudhuri

  • Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

    G A Sprenger;U Schörken;T Wiegert;S Grolle

  • Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry.

    Ying Ge;Brian G Lawhorn;Mariam ElNaggar;Erick Strauss

  • Thiamin biosynthesis in prokaryotes.

    Begley Tp;Downs Dm;Ealick Se;McLafferty Fw

  • The Structural and Biochemical Foundations of Thiamin Biosynthesis

    Christopher T. Jurgenson;Tadhg P. Begley;Steven E. Ealick

  • High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin.

    Mei-Fen Jeng;A.Patricia Campbell;Tadhg Begley;Arne Holmgren

  • NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.

    Oleg Kurnasov;Vasiliy Goral;Keri Colabroy;Svetlana Gerdes

  • The biosynthesis of coenzyme A in bacteria.

    Tadhg P Begley;Cynthia Kinsland;Erick Strauss

  • Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin.

    Clifton E. Barry;Parmesh G. Nayar;Tadhg P. Begley

  • The crystal structure and mechanism of orotidine 5′-monophosphate decarboxylase

    Todd C. Appleby;Cynthia Kinsland;Tadhg P. Begley;Steven E. Ealick

  • Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.

    Ruchi Anand;Pieter C. Dorrestein;Cynthia Kinsland;Tadhg P. Begley

  • Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics.

    Fred W. McLafferty;Kathrin Breuker;Mi Jin;Xuemei Han

  • Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation.

    Sean V. Taylor;Neil L. Kelleher;Cynthia Kinsland;Hsiu-Ju Chiu

  • Crystal Structure of Mammalian Cysteine Dioxygenase: A NOVEL MONONUCLEAR IRON CENTER FOR CYSTEINE THIOL OXIDATION.

    Chad R. Simmons;Qun Liu;Qingqiu Huang;Quan Hao

  • Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase

    Abhishek Chatterjee;Abhishek Chatterjee;N. Dinuka Abeydeera;Shridhar Bale;Shridhar Bale;Pei-Jing Pai

  • Wiley encyclopedia of chemical biology

    Tadhg P. Begley

  • Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

    Abhishek Chatterjee;Yue Li;Yang Zhang;Tyler L Grove

  • Discovery of a SAR11 growth requirement for thiamin's pyrimidine precursor and its distribution in the Sargasso Sea.

    Paul Carini;Paul Carini;Emily O Campbell;Jeff Morré;Sergio A Sañudo-Wilhelmy

  • PHOTOENZYMES : A NOVEL CLASS OF BIOLOGICAL CATALYSTS

    Tadhg P. Begley

  • Phenoxazinone synthase: enzymatic catalysis of an aminophenol oxidative cascade

    Clifton E. Barry;Parmesh G. Nayar;Tadhg P. Begley

  • Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12.

    P B Vander Horn;A D Backstrom;V Stewart;T P Begley

  • The biosynthesis of nicotinamide adenine dinucleotides in bacteria

    Tadhg P Begley;Cynthia Kinsland;Ryan A Mehl;Andrei Osterman

Frequent Co-Authors

Steven E. Ealick
Steven E. Ealick Cornell University
Fred W. McLafferty
Fred W. McLafferty Cornell University
Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego
Neil L. Kelleher
Neil L. Kelleher Northwestern University
Sean T. O’Leary
Sean T. O’Leary University of Colorado Anschutz Medical Campus
Ying Ge
Ying Ge University of Wisconsin–Madison
Andrei L. Osterman
Andrei L. Osterman Discovery Institute
Kanagalaghatta R. Rajashankar
Kanagalaghatta R. Rajashankar Argonne National Laboratory
Kari I. Kivirikko
Kari I. Kivirikko University of Oulu
Johanna Myllyharju
Johanna Myllyharju University of Oulu

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