World's Best Scientists 2026 revealed!

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Chemistry

D-Index
67
Citations
13438
World Ranking
7061
National Ranking
2098

Biology and Biochemistry

D-Index
67
Citations
13191
World Ranking
8362
National Ranking
3772

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Steven E. Ealick is affiliated with Cornell University in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional work related to Medicine. The scientist's subfields of study include Molecular Biology, Parasitology, Epidemiology, Public Health, Environmental and Occupational Health, and Genetics.

The research conducted by Steven E. Ealick covers multiple topics, such as RNA modifications and cancer, biochemical and molecular research, vector-borne infectious diseases, RNA regulation and disease, Trypanosoma species research and implications, research on leishmaniasis studies, and virus-based gene therapy research.

Steven E. Ealick has published papers in several peer-reviewed venues, including:

  • Biochemistry (2 publications)
  • mBio
  • Cancer Chemotherapy and Pharmacology
  • Current Research in Structural Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent publications include:

  • "Structural Basis of the Substrate Selectivity of Viperin," 2020, Biochemistry
  • "The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors," 2020, Cancer Chemotherapy and Pharmacology
  • "Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi," 2025, mBio
  • "Structural basis of elongation factor 2 switching," 2020, Current Research in Structural Biology
  • "Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi," 2025, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include Michael K. Fenwick, Ching Wooen Sze, Michael J. Lynch, David B. Neau, and Brian R. Crane. Collaborations with these co-authors have resulted in multiple publications across the topics and venues listed.

In 2010, Steven E. Ealick was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Three-dimensional structure of recombinant human interferon-gamma

    Unknown

  • Thiamin biosynthesis in prokaryotes.

    Begley Tp;Downs Dm;Ealick Se;McLafferty Fw

  • The Structural and Biochemical Foundations of Thiamin Biosynthesis

    Christopher T. Jurgenson;Tadhg P. Begley;Steven E. Ealick

  • Flavogenomics – a genomic and structural view of flavin‐dependent proteins

    Unknown

  • Structural biology of the purine biosynthetic pathway

    Unknown

  • Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors

    S.E. Ealick;Y.S. Babu;C.E. Bugg;Erion

  • The crystal structure and mechanism of orotidine 5′-monophosphate decarboxylase

    Todd C. Appleby;Cynthia Kinsland;Tadhg P. Begley;Steven E. Ealick

  • Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.

    Ruchi Anand;Pieter C. Dorrestein;Cynthia Kinsland;Tadhg P. Begley

  • Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

    Yang Zhang;Xuling Zhu;Andrew T. Torelli;Michael Lee

  • Purine nucleoside phosphorylase. 2. Catalytic mechanism.

    Mark D. Erion;Johanna D. Stoeckler;Wayne C. Guida;Richard L. Walter

  • Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase

    Abhishek Chatterjee;Abhishek Chatterjee;N. Dinuka Abeydeera;Shridhar Bale;Shridhar Bale;Pei-Jing Pai

  • Structure of Human Adenosine Kinase at 1.5 Å Resolution<sup>,</sup>

    Unknown

  • Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

    Abhishek Chatterjee;Yue Li;Yang Zhang;Tyler L Grove

  • Crystallographic and modeling methods in molecular design

    Charles E. Bugg;Steven E. Ealick

  • Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

    J. A. Montgomery;S. Niwas;J. D. Rose;J. A. Secrist

  • Active Site Amino Acids That Participate in the Catalytic Mechanism of Nucleoside 2′-Deoxyribosyltransferase

    Steven A. Short;Shelly R. Armstrong;Steven E. Ealick;David J.T. Porter

  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.

    Maria A Schumacher;Daniel M Scott;Iripam I Mathews;Steven E Ealick

  • Multiple wavelength anomalous diffraction (MAD) crystal structure of rusticyanin: a highly oxidizing cupredoxin with extreme acid stability.

    Richard L. Walter;Steven E. Ealick;Alan M. Friedman;Robert C. Blake

  • Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues.

    Chen Mao;William J. Cook;Min Zhou;Alexander A. Federov

  • Structural analyses reveal two distinct families of nucleoside phosphorylases

    Unknown

  • Crystal Structure and Mechanism of Tryptophan 2,3-Dioxygenase, a Heme Enzyme Involved in Tryptophan Catabolism and in Quinolinate Biosynthesis†,‡

    Yang Zhang;Seong A. Kang;Tathagata Mukherjee;Shridhar Bale

  • Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.

    DJ Thiel;M-H le Du;RL Walter;A D’Arcy

  • Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.

    Ethan C. Settembre;Pieter C. Dorrestein;Joo-Heon Park;Amy M. Augustine

  • Structural biology of enzymes of the thiamin biosynthesis pathway

    Ethan Settembre;Tadhg P Begley;Steven E Ealick

  • Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis

    Christopher Lehmann;Tadhg P. Begley;Steven E. Ealick

Frequent Co-Authors

Tadhg P. Begley
Tadhg P. Begley Texas A&M University
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University
Sol M. Gruner
Sol M. Gruner Cornell University
Kanagalaghatta R. Rajashankar
Kanagalaghatta R. Rajashankar Argonne National Laboratory
Sean T. O’Leary
Sean T. O’Leary University of Colorado Anschutz Medical Campus
Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego
Robert S. Klein
Robert S. Klein Washington University in St. Louis
Juan C. Fontecilla-Camps
Juan C. Fontecilla-Camps Centre national de la recherche scientifique, CNRS
Peter Macheroux
Peter Macheroux Graz University of Technology

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