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Materials Science

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Chemistry

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Overview

John R. Helliwell is affiliated with the University of Manchester in the United Kingdom. Their research spans multiple disciplines, primarily focusing on biochemistry, genetics, and molecular biology, as well as materials science. Within these fields, their work delves into molecular biology and materials chemistry, with additional contributions related to radiation, spectroscopy, and information systems.

The main topics covered in John R. Helliwell's research include enzyme structure and function, protein structure and dynamics, advanced X-ray imaging techniques, research data management practices, advanced electron microscopy techniques and applications, scientific computing and data management, and RNA and protein synthesis mechanisms.

John R. Helliwell has contributed to several recent papers, including:

  • "Microgravity as an environment for macromolecular crystallization - an outlook in the era of space stations and commercial space flight" (2021) published in Crystallography Reviews
  • "What is the structural chemistry of the living organism at its temperature and pressure?" (2020) published in Acta Crystallographica Section D Structural Biology
  • "Fundamentals of neutron crystallography in structural biology" (2020) published in Methods in enzymology on CD-ROM/Methods in enzymology
  • "Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure" (2024) published in Chemical Communications
  • "Combining X-rays, neutrons and electrons, and NMR, for precision and accuracy in structure-function studies" (2021) published in Acta Crystallographica Section A Foundations and Advances

Frequent co-authors include Alice Brink, Frederick J. F. Jacobs, Loes M. J. Kroon-Batenburg, James Hester, and Lata Govada.

John R. Helliwell has published extensively in several venues, including:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Journal of Applied Crystallography
  • Crystallography Reviews
  • Acta Crystallographica Section A Foundations and Advances
  • Acta Crystallographica Section D Structural Biology

Among their book contributions is a publication by Springer International Publishing titled Certifying Central Facility Beamlines for Biological and Chemical Crystallography and Allied Methods, slated for 2025.

John R. Helliwell was recognized as a Fellow of the Royal Society of Canada in 1976, reflecting their involvement in the Academy of Social Sciences.

Best Publications

  • Macromolecular Crystallography with Synchrotron Radiation

    John R. Helliwell

  • The structure of the saccharide-binding site of concanavalin A.

    Z. Derewenda;J. Yariv;J.R. Helliwell;A.J. Kalb

  • The interaction of bee melittin with lipid bilayer membranes

    C.R Dawson;A.F Drake;J Helliwell;R.C Hider

  • The molecular basis of the coloration mechanism in lobster shell: β-Crustacyanin at 3.2-Å resolution

    Michele Cianci;Pierre J. Rizkallah;Andrzej Olczak;James Raftery

  • The recording and analysis of synchrotron X-radiation Laue diffraction photographs

    J. R. Helliwell;J. Habash;D. W. J. Cruickshank;M. M. Harding

  • Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution.

    S E Ealick;S A Rule;D C Carter;T J Greenhough

  • Improvements in lysozyme protein crystal perfection through microgravity growth.

    E. H. Snell;S. Weisgerber;J. R. Helliwell;E. Weckert

  • Laue crystallography: coming of age

    Zhong Ren;Dominique Bourgeois;John R. Helliwell;Keith Moffat

  • Synchrotron X-radiation protein crystallography: instrumentation, methods and applications

    J R Helliwell

  • Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.

    J. H. Naismith;C. Emmerich;J. Habash;S. J. Harrop

  • Protein crystal perfection and the nature of radiation damage

    J.R. Helliwell;J.R. Helliwell

  • Multiplicity distribution of reflections in Laue diffraction

    D. W. J. Cruickshank;J. R. Helliwell;K. Moffat

  • Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens

    Nicola Pasquato;Rodolfo Berni;Claudia Folli;Silvia Folloni

  • X-Ray and molecular dynamics studies of concanavalin-A glucoside and mannoside complexes Relating structure to thermodynamics of binding

    Gail M. Bradbrook;Thomas Gleichmann;Stephen J. Harrop;Jarjis Habash

  • The structure of concanavalin A and its bound solvent determined with small-molecule accuracy at 0.94 [Aring ]resolution

    A. Deacon;T. Gleichmann;A. J. Kalb;H. Price

  • Active site of trypanothione reductase: A target for rational drug design

    William N. Hunter;Susan Bailey;Jarjis Habash;Stephen J. Harrop

  • Time-resolved diffraction

    John R. Helliwell;Peter M. Rentzepis

  • Macromolecular crystallization in microgravity

    Edward H Snell;John R Helliwell;John R Helliwell

  • Unravelling the structural chemistry of the colouration mechanism in lobster shell.

    Naomi E. Chayen;Michele Cianci;J. Günter Grossmann;Jarjis Habash

  • Trends and challenges in experimental macromolecular crystallography.

    N. E. Chayen;T. J. Boggon;A. Cassetta;A. Deacon

  • Structure of Lobster Apocrustacyanin A1 Using Softer X-Rays

    M. Cianci;P.J. Rizkallah;A. Olczak;J. Raftery

  • Piperazine silicate (EU 19): the structure of a very small crystal determined with synchrotron radiation

    S. J. Andrews;M. Z. Papiz;R. McMeeking;A. J. Blake

  • The Determination of Protonation States in Proteins.

    H.U. Ahmed;M.P. Blakeley;M. Cianci;D.W.J. Cruickshank

Frequent Co-Authors

Naomi E. Chayen
Naomi E. Chayen Imperial College London
James Raftery
James Raftery University of Manchester
S. Samar Hasnain
S. Samar Hasnain University of Liverpool
Kay Diederichs
Kay Diederichs University of Konstanz
Michael Wulff
Michael Wulff European Synchrotron Radiation Facility
Wladek Minor
Wladek Minor University of Virginia
Keith Moffat
Keith Moffat University of Chicago
James H. Naismith
James H. Naismith Rosalind Franklin Institute
Quan Hao
Quan Hao University of Hong Kong
Susan J. Fisher
Susan J. Fisher University of California, San Francisco

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