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Biology and Biochemistry

D-Index
91
Citations
35149
World Ranking
2296
National Ranking
156

Research.com Recognitions

  • 2001 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Alan H. Fairlamb is affiliated with the University of Dundee in the United Kingdom. Their research primarily focuses on the field of Medicine, with specific emphasis on Public Health, Environmental and Occupational Health, Epidemiology, Molecular Biology, Organic Chemistry, and Parasitology.

The main topics covered in Fairlamb's work include:

  • Research on Leishmaniasis Studies
  • Trypanosoma species research and implications
  • Biochemical and Molecular Research
  • Synthesis and Biological Evaluation
  • Parasites and Host Interactions
  • RNA and protein synthesis mechanisms
  • Parasitic Infections and Diagnostics

Fairlamb has published research in a variety of scientific venues. Frequent publication venues include:

  • ACS Infectious Diseases
  • European Journal of Medicinal Chemistry
  • ACS Medicinal Chemistry Letters
  • Cell chemical biology
  • PLoS Pathogens

Recent papers authored or co-authored by Fairlamb are:

  • "The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani", 2020, ACS Infectious Diseases
  • "Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial", 2021, Cell chemical biology
  • "8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi", 2020, European Journal of Medicinal Chemistry
  • "Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase", 2020, ACS Infectious Diseases
  • "Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity", 2021, ACS Medicinal Chemistry Letters

Fairlamb has worked frequently with co-authors including:

  • Susan Wyllie
  • Ian H. Gilbert
  • Richard J. Wall
  • Lorna MacLean
  • Stephen Patterson

In addition to journal articles, Fairlamb has contributed to book publications, notably with the University of Dundee eBooks, including the title "Para-Site-Seeing" published in 2020.

Recognized by professional bodies, Fairlamb was named a Fellow of the Royal Society of Edinburgh in 2001 and is a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Genome sequence of the human malaria parasite Plasmodium falciparum

    Malcolm J. Gardner;Neil Hall;Eula Fung;Owen White

  • Drug Resistance in Leishmaniasis

    Simon L. Croft;Shyam Sundar;Alan H. Fairlamb

  • The Genome of the African Trypanosome Trypanosoma brucei

    Matthew Berriman;Elodie Ghedin;Elodie Ghedin;Christiane Hertz-Fowler;Gaelle Blandin

  • Metabolism and functions of trypanothione in the kinetoplastida

    Alan H. Fairlamb;Anthony Cerami

  • Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

    Alan H. Fairlamb;Peter Blackburn;Peter Ulrich;Brian T. Chait

  • Kinetoplastids: related protozoan pathogens, different diseases

    Ken Stuart;Reto Brun;Simon Croft;Alan Fairlamb

  • Structure of trypanothione reductase from Crithidia fasciculata at 2.6 Å resolution; enzyme–NADP interactions at 2.8 Å resolution

    S. Bailey;A.H. Fairlamb;W.N. Hunter

  • A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Beatriz Baragaña;Irene Hallyburton;Marcus C. S. Lee;Marcus C. S. Lee;Neil R. Norcross

  • Chemotherapy of human African trypanosomiasis: current and future prospects

    Alan H. Fairlamb

  • Arsenical-resistant trypanosomes lack an unusual adenosine transporter.

    Nicola S. Carter;Alan H. Fairlamb

  • Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

    S. Krieger;W. Schwarz;M. R. Ariyanayagam;A. H. Fairlamb

  • Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

    Mark C. Field;David Horn;Alan H. Fairlamb;Michael A. J. Ferguson

  • Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

    Carole Dumas;Marc Ouellette;Jorge Tovar;Mark L. Cunningham

  • Dual action of antimonial drugs on thiol redox metabolism in the human pathogen leishmania donovani

    Susan Wyllie;Mark L. Cunningham;Alan H. Fairlamb

  • N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.

    Julie A. Frearson;Stephen Brand;Stuart P. McElroy;Laura A.T. Cleghorn

  • Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.

    Spencer L. Shames;Alan H. Fairlamb;Anthony Cerami;Christopher T. Walsh

  • Trypanothione is the primary target for arsenical drugs against African trypanosomes

    Alan H. Fairlamb;Graeme B. Henderson;Anthony Cerami

  • Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

    Julio Aliberti;Jesus G. Valenzuela;Vern B. Carruthers;Sara Hieny

  • Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen- sensitive and -resistant Trypanosoma brucei brucei

    Nicola S. Carter;Bradley J. Berger;Alan H. Fairlamb

  • Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

    R. Luise Krauth-Siegel;Burkhard Enders;Graeme B. Henderson;Alan H. Fairlamb

Frequent Co-Authors

Ian H. Gilbert
Ian H. Gilbert University of Dundee
Anthony Cerami
Anthony Cerami Araim Pharmaceuticals (United States)
Simon L. Croft
Simon L. Croft London School of Hygiene & Tropical Medicine
Kenneth T. Douglas
Kenneth T. Douglas University of Manchester
Michael A. J. Ferguson
Michael A. J. Ferguson University of Dundee
Matthew Berriman
Matthew Berriman University of Glasgow
Charles S. Bond
Charles S. Bond University of Western Australia
William N. Hunter
William N. Hunter University of Dundee
Shyam Sundar
Shyam Sundar Banaras Hindu University
David Horn
David Horn University of Dundee

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