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Genetics

D-Index
67
Citations
22435
World Ranking
2504
National Ranking
318

Overview

Thomas D. Otto is affiliated with the University of Glasgow in the United Kingdom. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Subfields of their work include Immunology, Public Health, Environmental and Occupational Health, Molecular Biology, Epidemiology, and Oncology.

Their scientific investigations cover a broad range of topics, notably Malaria Research and Control, Mosquito-borne diseases and control, Immune Cell Function and Interaction, Trypanosoma species research and implications, Invertebrate Immune Response Mechanisms, T-cell and B-cell Immunology, and the Complement system in diseases.

Thomas D. Otto has a record of publishing in several prominent venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • Frontiers in Immunology
  • eLife
  • Nature Communications

Selected recent papers authored or co-authored by Thomas D. Otto include:

  • Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis (2020, Nature Medicine)
  • Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (2020, Nature Medicine)
  • Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq (2020, BMC Genomics)
  • Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing (2021, Nature Communications)
  • COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes (2021, JCI Insight)

Thomas D. Otto frequently collaborates with several researchers, including:

  • Matthias Marti
  • Julian C. Rayner
  • Emma M. Briggs
  • Jenna Oberstaller
  • John H. Adams

Best Publications

  • A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers.

    Michael Quail;Miriam E. Smith;Paul Coupland;Thomas D. Otto

  • Circlator: automated circularization of genome assemblies using long sequencing reads

    Martin Hunt;Nishadi De Silva;Thomas D. Otto;Julian Parkhill

  • Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

    Min Zhang;Chengqi Wang;Thomas D. Otto;Jenna Oberstaller

  • Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species

    Keith R. Bradnam;Joseph N. Fass;Anton Alexandrov;Paul Baranay

  • Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species

    Keith R. Bradnam;Joseph N. Fass;Anton Alexandrov;Paul Baranay

  • Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.

    Stefano Alivernini;Lucy MacDonald;Aziza Elmesmari;Samuel Finlay

  • Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

    Samuel O. Oyola;Thomas D. Otto;Yong-ping Gu;Gareth Maslen

  • Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

    Matthew B. Rogers;James D. Hilley;Nicholas J. Dickens;Jon Wilkes

  • Two Nonrecombining Sympatric Forms of the Human Malaria Parasite Plasmodium ovale Occur Globally

    Colin J. Sutherland;Naowarat Tanomsing;Debbie Nolder;Mary Oguike

  • ABACAS: algorithm-based automatic contiguation of assembled sequences

    Samuel A. Assefa;Thomas M. Keane;Thomas D. Otto;Chris I Newbold

  • A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Beatriz Baragaña;Irene Hallyburton;Marcus C. S. Lee;Marcus C. S. Lee;Neil R. Norcross

  • New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

    Thomas D. Otto;Daniel Wilinski;Sammy Assefa;Thomas M. Keane

  • A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni.

    Anna V. Protasio;Isheng J. Tsai;Anne Babbage;Sarah Nichol

  • Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus.

    Taisei Kikuchi;James A. Cotton;Jonathan J. Dalzell;Koichi Hasegawa

  • REAPR: a universal tool for genome assembly evaluation.

    Martin Hunt;Taisei Kikuchi;Taisei Kikuchi;Mandy Sanders;Chris Newbold;Chris Newbold

  • Tumour class prediction and discovery by microarray-based DNA methylation analysis

    Péter Adorján;Jürgen Distler;Evelyne Lipscher;Fabian Model

  • A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

    Abhinav Sinha;Katie R. Hughes;Katarzyna K. Modrzynska;Thomas D. Otto

  • RATT: Rapid Annotation Transfer Tool

    Thomas D. Otto;Gary P. Dillon;Wim S. Degrave;Matthew Berriman

  • Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gaps.

    Isheng J Tsai;Thomas D Otto;Matthew Berriman

  • A comprehensive evaluation of rodent malaria parasite genomes and gene expression

    Thomas D Otto;Ulrike Böhme;Andrew P Jackson;Martin Hunt

Frequent Co-Authors

Matthew Berriman
Matthew Berriman University of Glasgow
Chris I. Newbold
Chris I. Newbold Wellcome Sanger Institute
Arnab Pain
Arnab Pain King Abdullah University of Science and Technology
Mandy Sanders
Mandy Sanders Wellcome Sanger Institute
Julian C. Rayner
Julian C. Rayner University of Cambridge
Dominic P. Kwiatkowski
Dominic P. Kwiatkowski University of Oxford
Julius Lukeš
Julius Lukeš Czech Academy of Sciences
David J. Conway
David J. Conway London School of Hygiene & Tropical Medicine
Ric N. Price
Ric N. Price Charles Darwin University
Simon R. Harris
Simon R. Harris Wellcome Sanger Institute

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