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Biology and Biochemistry

D-Index
69
Citations
22445
World Ranking
7274
National Ranking
118

Overview

Holger Heyn is affiliated with Pompeu Fabra University in Spain. Their research is primarily concentrated in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. The main subfields of study include Molecular Biology, Immunology, Oncology, Genetics, and Cancer Research.

The scientist's work focuses on several key topics, notably Single-cell and spatial transcriptomics, Immune cells in cancer, Cancer Immunotherapy and Biomarkers, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, T-cell and B-cell Immunology, and Cancer Genomics and Diagnostics.

Heyn has published research extensively in various scientific venues. Some of the most frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Genome Biology, Annals of Oncology, and Nature Biotechnology.

Their recent papers cover important advancements in transcriptomics and cellular biology:

  • SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes, 2021, Nucleic Acids Research
  • Benchmarking single-cell RNA-sequencing protocols for cell atlas projects, 2020, Nature Biotechnology
  • The emerging landscape of spatial profiling technologies, 2022, Nature Reviews Genetics
  • Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data, 2020, Genome Biology
  • Dietary palmitic acid promotes a prometastatic memory via Schwann cells, 2021, Nature

Collaboration is a consistent part of Heyn's research activity. Frequent co-authors include Doménica Marchese, Ginevra Caratù, Elisabetta Mereu, Juan C. Nieto, and Paula Nieto, with multiple joint publications indicating sustained scientific partnerships.

Best Publications

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • Global Epigenomic Reconfiguration During Mammalian Brain Development

    Ryan Lister;Ryan Lister;Eran A. Mukamel;Joseph R. Nery;Mark Urich

  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

    Tathiane M Malta;Artem Sokolov;Andrew J Gentles;Tomasz Burzykowski

  • Comparative Analysis of Single-Cell RNA Sequencing Methods.

    Christoph Ziegenhain;Beate I.H. Vieth;Swati Parekh;Björn Reinius

  • Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome.

    Juan Sandoval;Holger Heyn;Sebastian Moran;Jordi Serra-Musach

  • Distinct DNA methylomes of newborns and centenarians

    Holger Heyn;Ning Li;Humberto J. Ferreira;Sebastian Moran

  • DNA methylation profiling in the clinic: applications and challenges

    Holger Heyn;Manel Esteller;Manel Esteller

  • SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes.

    Marc Elosua-Bayés;Paula Nieto;Elisabetta Mereu;Ivo Glynne Gut

  • Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

    Sebastian Moran;Anna Martínez-Cardús;Sergi Sayols;Eva Musulén

  • DNA methylation contributes to natural human variation

    Holger Heyn;Sebastian Moran;Irene Hernando-Herraez;Sergi Sayols

  • Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects

    Elisabetta Mereu;Atefeh Lafzi;Catia Moutinho;Christoph Ziegenhain

  • A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

    Juan Sandoval;Jesus Mendez-Gonzalez;Ernest Nadal;Guoan Chen

  • Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

    Christian H. Holland;Christian H. Holland;Jovan Tanevski;Jovan Tanevski;Javier Perales-Patón;Jan Gleixner;Jan Gleixner

  • DNA methylation map of human atherosclerosis.

    Silvio Zaina;Holger Heyn;F. Javier Carmona;Nuray Varol

  • Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response

    Inga Köllner;Beate Sodeik;Sabine Schreek;Holger Heyn

  • Dynamics of DNA Methylation in Recent Human and Great Ape Evolution

    Irene Hernando-Herraez;Javier Prado-Martinez;Paras Garg;Marcos Fernandez-Callejo

  • Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer.

    Holger Heyn;Enrique Vidal;Humberto J. Ferreira;Miguel Vizoso

  • Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging.

    Marion Claudia Salzer;Atefeh Lafzi;Antoni Berenguer-Llergo;Catrin Youssif

  • Single-cell transcriptomics unveils gene regulatory network plasticity

    Giovanni Iacono;Ramon Massoni-Badosa;Holger Heyn

  • Dietary palmitic acid promotes a prometastatic memory via Schwann cells

    Gloria Pascual;Diana Domínguez;Marc Elosúa-Bayes;Felipe Beckedorff

Frequent Co-Authors

Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute
Marta Gut
Marta Gut Centro Nacional de Análisis Genómico
Alberto Villanueva
Alberto Villanueva Memorial Sloan Kettering Cancer Center
Ivo Gut
Ivo Gut Centro Nacional de Análisis Genómico
August Vidal
August Vidal University of Barcelona
Oliver Stegle
Oliver Stegle German Cancer Research Center
Tomas Marques-Bonet
Tomas Marques-Bonet Pompeu Fabra University
Aviv Regev
Aviv Regev Genentech
Christine E. Seidman
Christine E. Seidman Harvard University
Joshua M. Stuart
Joshua M. Stuart University of California, Santa Cruz

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