World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
66
Citations
23899
World Ranking
2579
National Ranking
99

Research.com Recognitions

  • 2020 - Fellow of the International Society for Computational Biology

Overview

Osamu Gotoh is affiliated with the Japanese Foundation For Cancer Research. Their research spans fields primarily within Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Oncology, Molecular Biology, Cancer Research, Genetics, and Obstetrics and Gynecology.

They have contributed to the study of various topics including:

  • Endometrial and Cervical Cancer Treatments
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • BRCA gene mutations in cancer
  • DNA Repair Mechanisms
  • Genetic factors in colorectal cancer
  • Colorectal Cancer Surgical Treatments

Some of the recent papers with which Osamu Gotoh has been involved include:

  • "Sequencing artifacts derived from a library preparation method using enzymatic fragmentation", 2020, published in PLoS ONE
  • "T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer", 2020, published in Cancer Immunology Immunotherapy
  • "Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome", 2020, published in npj Breast Cancer
  • "Genomic determinants impacting the clinical outcome of mogamulizumab treatment for adult T-cell leukemia/lymphoma", 2022, published in Haematologica
  • "Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma", 2024, published in The Journal of Pathology

Frequent coauthors collaborating in research efforts with Osamu Gotoh include:

  • Seiichi Mori
  • Norio Tanaka
  • Tetsuo Noda
  • Tomoko Kaneyasu
  • Sayuri Amino

Publication venues where Osamu Gotoh's work frequently appears include:

  • The Journal of Pathology
  • Gynecologic Oncology
  • PLoS ONE
  • Cancer Immunology Immunotherapy
  • npj Breast Cancer

In 2020, Osamu Gotoh was recognized as a Fellow of the International Society for Computational Biology. This affiliation acknowledges contributions within computational biology aspects related to their research domain.

Best Publications

  • P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature

    David R. Nelson;Luc Koymans;Tetsuya Kamataki;John J. Stegeman

  • An improved algorithm for matching biological sequences

    Osamu Gotoh

  • The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

    D R Nelson;T Kamataki;D J Waxman;F P Guengerich

  • Genome sequencing and analysis of Aspergillus oryzae

    Masayuki Machida;Kiyoshi Asai;Motoaki Sano;Toshihiro Tanaka

  • Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

    O Gotoh

  • Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene

    Yujiro Higashi;Hidefumi Yoshioka;Miyuki Yamane;Osamu Gotoh

  • cDNA cloning and structure of mouse putative Ah receptor

    M. Ema;K. Sogawa;N. Watanabe;Y. Chujoh

  • Significant Improvement in Accuracy of Multiple Protein Sequence Alignments by Iterative Refinement as Assessed by Reference to Structural Alignments

    Osamu Gotoh

  • Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.

    O Gotoh;T Asano;T Koide;K Takakura

  • Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

    Hideta Fujii;Takashi Sato;Sinya Kaneko;Osamu Gotoh

  • cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).

    Ken Hirose;Masanobu Morita;Masatsugu Ema;Junsei Mimura

  • Stabilities of nearest‐neighbor doublets in double‐helical DNA determined by fitting calculated melting profiles to observed profiles

    Osamu Gotoh;Yusaku Tagashira

  • Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.

    Junko Watanabe;Tsutomu Shimada;Elizabeth M. J. Gillam;Togo Ikuta

  • Benchmarking spliced alignment programs including Spaln2, an extended version of Spaln that incorporates additional species-specific features.

    Hiroaki Iwata;Osamu Gotoh

  • Hybrid origin of Japanese mice "Mus musculus molossinus": evidence from restriction analysis of mitochondrial DNA.

    H Yonekawa;K Moriwaki;O Gotoh;N Miyashita

  • Optimal alignment between groups of sequences and its application to multiple sequence alignment

    Osamu Gotoh

  • Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.

    Kazuhiro Sogawa;Osamu Gotoh;Kaname Kawajiri;Yoshiaki Fujii-Kuriyama

  • Prediction of melting profiles and local helix stability for sequenced DNA.

    Osamu Gotoh

  • Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

    Kaname Kawajiri;Osamu Gotoh;Kazuhiro Sogawa;Yusaku Tagashira

  • Nucleotide sequence of a functional cDNA for human thymidylate synthase

    Keiichi Takeishi;Sumiko Kaneda;Dai Ayusawa;Kimiko Shimizu

Frequent Co-Authors

Hiromichi Yonekawa
Hiromichi Yonekawa Tokyo Metropolitan Institute of Medical Science
Kazuhiro Sogawa
Kazuhiro Sogawa Tohoku University
Mitsuhide Noshiro
Mitsuhide Noshiro Hiroshima University
Jun-Ichi Hayashi
Jun-Ichi Hayashi University of Tsukuba
Tetsuo Noda
Tetsuo Noda Japanese Foundation For Cancer Research
Yoshiaki Fujii-Kuriyama
Yoshiaki Fujii-Kuriyama Tokyo Medical and Dental University
Kazuo Moriwaki
Kazuo Moriwaki National Institute of Genetics
Takeshi Kawamoto
Takeshi Kawamoto Hiroshima University
Ken-ichirou Morohashi
Ken-ichirou Morohashi Kyushu University
Yukio Kato
Yukio Kato Hiroshima University

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