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Biology and Biochemistry

D-Index
47
Citations
7507
World Ranking
18738
National Ranking
7655

Overview

Leslie A. Khawli is affiliated with the University of Southern California in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a concentration in subfields such as Radiology, Nuclear Medicine and Imaging, Molecular Biology, Immunology, Oncology, and Biomaterials.

The scientist's work covers several main topics, including Monoclonal and Polyclonal Antibodies Research, CAR-T Cell Therapy Research, Viral Infectious Diseases and Gene Expression in Insects, Glycosylation and Glycoproteins Research, Galectins and Cancer Biology, Nanoparticle-Based Drug Delivery, and RNA Interference and Gene Delivery.

Their publication record includes recent papers such as:

  • Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations, 2020, Antibodies
  • Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives, 2021, International Journal of Molecular Sciences
  • A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models, 2020, Clinical Cancer Research
  • Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model, 2021, Scientific Reports
  • Advances in Immuno-PET for the Detection of Cancer and Assessment of Response to Therapy, 2020, Current Medicinal Chemistry

These publications reflect Leslie A. Khawli's focus on antibody-based therapeutics, CAR-T cell therapy, and imaging techniques related to oncology and immunology.

Frequent collaborators in their research include Alan L. Epstein, Peisheng Hu, Aida Kouhi, Vyshnavi Pachipulusu, and Long Zheng. This network of co-authors indicates active participation in collaborative studies within related biomedical fields.

The scientist's work has appeared in diverse academic venues, specifically:

  • Antibodies
  • International Journal of Molecular Sciences
  • Clinical Cancer Research
  • Scientific Reports
  • Current Medicinal Chemistry

These journals cover immunology, molecular sciences, cancer research, and medicinal chemistry, aligning with their multidisciplinary research interests. The span of publication venues indicates engagement with both fundamental biochemical research and clinical applications.

Best Publications

  • Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

    Ben-Quan Shen;Keyang Xu;Luna Liu;Helga Raab

  • Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

    Leslie A. Khawli;Sirj Goswami;Ryan Hutchinson;Zephania W. Kwong

  • Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

    C. Andrew Boswell;Devin B. Tesar;Kiran Mukhyala;Frank-Peter Theil

  • Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges.

    Yulia Vugmeyster;Xin Xu;Frank-Peter Theil;Leslie A Khawli

  • Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

    C. Andrew Boswell;Eduardo E. Mundo;Crystal Zhang;Daniela Bumbaca

  • Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development.

    Jay Tibbitts;David Canter;Ryan Graff;Alison Smith

  • Enhanced Tumor Uptake of Macromolecules Induced by a Novel Vasoactive Interleukin 2 Immunoconjugate

    Brian LeBerthon;Leslie A. Khawli;Mian Alauddin;Gordon K. Miller

  • Pivotal Study of Iodine-131–Labeled Chimeric Tumor Necrosis Treatment Radioimmunotherapy in Patients With Advanced Lung Cancer

    Shaoliang Chen;Like Yu;Changying Jiang;Yan Zhao

  • Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

    Yanan Zheng;Devin B Tesar;Lisa Benincosa;Herbert Birnböck

  • Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors

    Jason L. Hornick;Leslie A. Khawli;Peisheng Hu;Jahangir Sharifi

  • Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

    Daniela Bumbaca;C. Andrew Boswell;Paul J. Fielder;Leslie A. Khawli

  • Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model

    Cinthia V Pastuskovas;Eduardo E Mundo;Simon P Williams;Tapan K Nayak

  • A Chimeric Lym-1/Interleukin 2 Fusion Protein for Increasing Tumor Vascular Permeability and Enhancing Antibody Uptake

    Peisheng Hu;Jason L. Hornick;Michelle S. Glasky;Aoyun Yun

  • A new chemically modified chimeric TNT-3 monoclonal antibody directed against DNA for the radioimmunotherapy of solid tumors.

    Jason L. Hornick;Jahangir Sharifi;Leslie A. Khawli;Peisheng Hu

  • Comparison of Three Different Targeted Tissue Factor Fusion Proteins for Inducing Tumor Vessel Thrombosis

    Peisheng Hu;Jianghua Yan;Jahangir Sharifi;Thomas Bai

  • Effect of seven new vasoactive immunoconjugates on the enhancement of monoclonal antibody uptake in tumors

    Leslie A. Khawli;Gordon K. Miller;Alan L. Epstein

  • Complete Regression of Experimental Solid Tumors by Combination LEC/ chTNT-3 Immunotherapy and CD25+ T-Cell Depletion

    Jiali Li;Peisheng Hu;Leslie A. Khawli;Alan L. Epstein

  • A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components.

    Hanne M. Kinnunen;Vikas Sharma;Luis Rodrigo Contreras-Rojas;Yafei Yu

  • Improving monoclonal antibody pharmacokinetics via chemical modification.

    J Sharifi;L A Khawli;J L Hornick;A L Epstein

  • Generation of rituximab polymer may cause hyper-cross-linking-induced apoptosis in non-Hodgkin's lymphomas.

    Nan Zhang;Leslie A. Khawli;Peisheng Hu;Alan L. Epstein

Frequent Co-Authors

Alan L. Epstein
Alan L. Epstein University of Southern California
Jason L. Hornick
Jason L. Hornick Brigham and Women's Hospital
Clive R. Taylor
Clive R. Taylor University of Southern California
Paul Polakis
Paul Polakis Genentech
Dan L. Longo
Dan L. Longo Harvard University
Yung-Chi Cheng
Yung-Chi Cheng Yale University
Russell E. Jacobs
Russell E. Jacobs University of Southern California
Ryan J. Watts
Ryan J. Watts Denali Therapeutics (United States)
Mahin D. Maines
Mahin D. Maines University of Rochester

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