World's Best Scientists 2026 revealed!
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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
142
Citations
70373
World Ranking
153
National Ranking
103

Medicine

D-Index
142
Citations
70390
World Ranking
1570
National Ranking
916

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award

Overview

Jeffrey Schlom is affiliated with the National Institutes of Health in the United States and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research primarily focuses on Oncology, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Biotechnology.

Their work encompasses major topics such as Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, CAR-T cell therapy research, Prostate Cancer Treatment and Research, Cancer Research and Treatments, Immune Cell Function and Interaction, and Immune cells in cancer.

Frequently published in scientific venues, Schlom has a notable record in the following journals and collections:

  • Regular and Young Investigator Award Abstracts
  • Journal for ImmunoTherapy of Cancer
  • Journal of Clinical Oncology
  • Cancer Research
  • Cancer Immunology Research

Among the frequent co-authors in Schlom's collaborations are James L. Gulley, Renee N. Donahue, Julius Strauss, Jason M. Redman, and Claudia Palena.

Selected recent papers include:

  • Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances, 2020, Journal for ImmunoTherapy of Cancer
  • Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies, 2020, Journal for ImmunoTherapy of Cancer
  • Dual inhibition of TGF-β and PD-L1: a novel approach to cancer treatment, 2021, Molecular Oncology
  • PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations, 2020, Journal for ImmunoTherapy of Cancer
  • Therapeutic Vaccines for HPV-Associated Malignancies, 2020, ImmunoTargets and Therapy

Schlom's work often addresses mechanisms related to TGF-β and PD-L1 in cancer immunotherapy, with a focus on developing novel therapeutic strategies that involve immune checkpoint targeting and modulation of the tumor microenvironment.

Best Publications

  • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

    Eric A. Reits;James W Hodge;Carla A Herberts;Tom A M Groothuis

  • Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

    M. E. Christine Lutsiak;Roshanak T. Semnani;Roberto De Pascalis;Syed V. S. Kashmiri

  • Rapid Tumor Penetration of a Single-Chain Fv and Comparison with Other Immunoglobulin Forms

    Takashi Yokota;Diane E. Milenic;Marc Whitlow;Jeffrey Schlom

  • Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

    Philip W. Kantoff;Thomas J. Schuetz;Brent A. Blumenstein;L. Michael Glode

  • Grafting of “Abbreviated” Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody

    Roberto De Pascalis;Makoto Iwahashi;Midori Tamura;Eduardo A. Padlan

  • A spectrum of monoclonal antibodies reactive with human mammary tumor cells

    D Colcher;P H Hand;M Nuti;J Schlom

  • Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

    Tsang Ky;Zaremba S;Nieroda Ca;Zhu Mz

  • Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors.

    Donald Kufe;Giorgio Inghirami;Miyako Abe;Daniel Hayes

  • Distribution of Oncofetal Antigen Tumor-associated Glycoprotein-72 Defined by Monoclonal Antibody B72.3

    Ann Thor;Noriaki Ohuchi;Cheryl A. Szpak;William W. Johnston

  • Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes

    Charlie T. Garnett;Claudia Palena;Mala Chakarborty;Kwong-Yok Tsang

  • Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells.

    Benjamin Boyerinas;Caroline Jochems;Massimo Fantini;Christopher R. Heery

  • Analysis of a Human Tumor-associated Glycoprotein (TAG-72) Identified by Monoclonal Antibody B72.3

    Virginia G. Johnson;Jeffrey Schlom;Andrew J. Paterson;Jeffrey Bennett

  • Construction, Binding Properties, Metabolism, and Tumor Targeting of a Single-Chain Fv Derived from the Pancarcinoma Monoclonal Antibody CC49

    D. E. Milenic;T. Yokota;D. R. Filpula;M. A. J. Finkelman

  • Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

    John L. Marshall;Robert J. Hoyer;Mary Ann Toomey;Kristen Faraguna

  • External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.

    Mala Chakraborty;Scott I. Abrams;C. Norman Coleman;Kevin Camphausen

  • An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability.

    Mare Whitlow;Brian A. Bell;Sheau-Line Feng;David Filpula

  • Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies

    Martin W. Brechbiel;Otto A. Gansow;Robert W. Atcher;Jeffrey Schlom

  • Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity.

    Caroline Jochems;Jeffrey Schlom

  • A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen

    M. A. Morse;Yuping Deng;D. Coleman;S. Hull

  • In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

    David Colcher;Robert Bird;Mario Roselli;Karl D. Hardman

  • Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

    Sam Zaremba;Elena Barzaga;Mingzhu Zhu;Nirmolini Soares

Frequent Co-Authors

James L. Gulley
James L. Gulley National Institutes of Health
James W. Hodge
James W. Hodge National Institutes of Health
John W. Greiner
John W. Greiner National Institutes of Health
Kwong Y. Tsang
Kwong Y. Tsang National Institutes of Health
Philip M. Arlen
Philip M. Arlen National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Diane E. Milenic
Diane E. Milenic National Institutes of Health
Scott I. Abrams
Scott I. Abrams Roswell Park Cancer Institute
Albert F. LoBuglio
Albert F. LoBuglio University of Alabama at Birmingham
Ann D. Thor
Ann D. Thor University of Colorado Anschutz Medical Campus

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