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Immunology

D-Index
68
Citations
15227
World Ranking
2608
National Ranking
1245

Overview

Kwong Y. Tsang is affiliated with the National Institutes of Health in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on radiology and molecular biology subfields including oncology, immunology, and organic chemistry.

Their work mainly revolves around topics such as monoclonal and polyclonal antibodies research, glycosylation and glycoproteins research, immunotherapy and immune responses, radiopharmaceutical chemistry and applications, cancer treatment and pharmacology, and cancer immunotherapy and biomarkers.

Frequent coauthors who have collaborated with Tsang include:

  • Philip M. Arlen
  • Massimo Fantini
  • Christina M. Annunziata
  • Sharon Mavroukakis
  • Anjum Zaki

Tsang has published extensively in several venues, with a particular concentration in:

  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Journal of Clinical Oncology
  • Journal of Experimental & Clinical Cancer Research
  • Cancers

Among recent notable publications are:

  • "Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy," 2023, Frontiers in Immunology
  • "First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors," 2023, Journal of Experimental & Clinical Cancer Research
  • "The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway," 2020, Cancer Biotherapy and Radiopharmaceuticals
  • "Development and Characterization of an Anti-Cancer Monoclonal Antibody for Treatment of Human Carcinomas," 2022, Cancers
  • "Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer," 2020, Clinical Cancer Research

Tsang's research contributions include the development and characterization of monoclonal antibodies for cancer treatment and the study of immune responses related to cancer immunotherapy. Their investigations often intersect with studies involving radiopharmaceutical chemistry applications and molecular mechanisms underlying antibody-based therapies.

Best Publications

  • Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

    Tsang Ky;Zaremba S;Nieroda Ca;Zhu Mz

  • Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes

    Charlie T. Garnett;Claudia Palena;Mala Chakarborty;Kwong-Yok Tsang

  • Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells.

    Benjamin Boyerinas;Caroline Jochems;Massimo Fantini;Christopher R. Heery

  • Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

    John L. Marshall;Robert J. Hoyer;Mary Ann Toomey;Kristen Faraguna

  • Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

    James L. Gulley;Philip M. Arlen;Anne Bastian;Steven Morin

  • A phase I trial of a recombinant vaccinia virus expressing prostate-specific antigen in advanced prostate cancer.

    Joseph Paul Eder;Philip W. Kantoff;Kristin Roper;GuangXian Xu

  • Phase I Study of Sequential Vaccinations With Fowlpox-CEA(6D)-TRICOM Alone and Sequentially With Vaccinia-CEA(6D)-TRICOM, With and Without Granulocyte-Macrophage Colony-Stimulating Factor, in Patients With Carcinoembryonic Antigen–Expressing Carcinomas

    John L. Marshall;James L. Gulley;Philip M. Arlen;Patricia K. Beetham

  • Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

    Sofia R. Gameiro;Momodou L. Jammeh;Max M. Wattenberg;Kwong Y. Tsang

  • Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial.

    Ravi A Madan;Mahsa Mohebtash;Philip M Arlen;Matteo Vergati

  • Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule.

    Heidi Hörig;David S. Lee;William Conkright;Joe Divito

  • Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer.

    James L. Gulley;Philip M. Arlen;Ravi A. Madan;Kwong-Yok Tsang

  • A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.

    Philip M Arlen;James L Gulley;Catherine Parker;Lisa Skarupa

  • In Vitro Generation of Human Cytotoxic T Lymphocytes Specific for Peptides Derived From Prostate-Specific Antigen

    Pierpaolo Correale;Konstantin Walmsley;Carol Nieroda;Sam Zaremba

  • Chemotherapy‐induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

    James W. Hodge;Charlie T. Garnett;Benedetto Farsaci;Claudia Palena

  • Phase I study in cancer patients of a replication-defective avipox recombinant vaccine that expresses human carcinoembryonic antigen.

    John L. Marshall;Michael J. Hawkins;Kwong Y. Tsang;Ellen Richmond

  • Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV-PSA) in patients with metastatic androgen-independent prostate cancer.

    James Gulley;Alice P. Chen;William Dahut;Philip M. Arlen

  • Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma

    James L. Gulley;Philip M. Arlen;Kwong-Yok Tsang;Junko Yokokawa

  • The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma

    M von Mehren;P Arlen;J Gulley;A Rogatko

  • Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy.

    Pierpaolo Correale;Maria Saveria Rotundo;Maria Teresa Del Vecchio;Cinzia Remondo

  • Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

    Junko Yokokawa;Vittore Cereda;Cinzia Remondo;James L. Gulley

  • Abstract 632: Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

    Sofia R. Gameiro;Momodou L. Jammeh;Max M. Wattenberg;Kwong Y. Tsang

Frequent Co-Authors

Jeffrey Schlom
Jeffrey Schlom National Institutes of Health
James L. Gulley
James L. Gulley National Institutes of Health
Philip M. Arlen
Philip M. Arlen National Institutes of Health
Massimo Fantini
Massimo Fantini Precision Biologics
James W. Hodge
James W. Hodge National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
John W. Greiner
John W. Greiner National Institutes of Health
Dennis Panicali
Dennis Panicali Harvard University
Ira Pastan
Ira Pastan Center for Cancer Research
Raymond P. Donnelly
Raymond P. Donnelly US Food and Drug Administration

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Related Online Degrees & Career Pathways

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