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Biology and Biochemistry

D-Index
62
Citations
16987
World Ranking
10639
National Ranking
4623

Overview

Massimo Fantini is affiliated with Precision Biologics in the United States and has contributed extensively to research in medicine, with a particular focus on biochemistry, genetics, and molecular biology. Their work spans multiple subfields, including radiology, nuclear medicine and imaging, molecular biology, oncology, immunology, and organic chemistry.

The scientist's research topics emphasize monoclonal and polyclonal antibodies, glycosylation and glycoproteins, immunotherapy and immune responses, radiopharmaceutical chemistry and applications, cancer treatment and pharmacology, cancer immunotherapy and biomarkers, as well as cancer research and treatments.

Among the recent papers involving Massimo Fantini are:

  • First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors, 2023, Journal of Experimental & Clinical Cancer Research
  • The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway, 2020, Cancer Biotherapy and Radiopharmaceuticals
  • Development and Characterization of an Anti-Cancer Monoclonal Antibody for Treatment of Human Carcinomas, 2022, Cancers
  • Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference, 2025, Inflammatory Bowel Diseases
  • Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer, 2020, Clinical Cancer Research

Frequent co-authors collaborating with Massimo Fantini include Kwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata, Sharon Mavroukakis, and Anjum Zaki. This indicates recurring collaborative relationships across various projects.

Massimo Fantini has published in several venues multiple times, notably:

  • Regular and Young Investigator Award Abstracts
  • Journal of Clinical Oncology
  • Cancer Research
  • Journal of Experimental & Clinical Cancer Research
  • Cancers

The scientist's work contributes broadly to understanding and developing treatments related to cancer, immunotherapy, and molecular targeted agents, with particular attention to monoclonal antibodies and their applications in oncology and related biomedical fields.

Best Publications

  • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7.

    Massimo C. Fantini;Christoph Becker;Giovanni Monteleone;Francesco Pallone

  • TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

    Christoph Becker;Massimo C. Fantini;Christoph Schramm;Hans A. Lehr

  • Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.

    V De Simone;E Franzè;G Ronchetti;A Colantoni

  • Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells.

    Benjamin Boyerinas;Caroline Jochems;Massimo Fantini;Christopher R. Heery

  • TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells ☆ ☆☆ ★ ★★ ♢

    Philip Rosenstiel;Massimo Fantini;Massimo Fantini;Karen Bräutigam;Tanja Kühbacher

  • Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

    Giovanni Monteleone;Markus F. Neurath;Sandro Ardizzone;Antonio Di Sabatino

  • High resolution colonoscopy in live mice.

    C Becker;M C Fantini;M F Neurath

  • IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

    Ilaria Peluso;Massimo Claudio Fantini;Daniele Fina;Roberta Caruso

  • In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment

    Massimo Fantini;Monica Benvenuto;Laura Masuelli;Giovanni Vanni Frajese

  • Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

    Daniele Fina;Massimiliano Sarra;Massimo C. Fantini;Angelamaria Rizzo

  • IL-6 signaling promotes tumor growth in colorectal cancer.

    C Becker;M C Fantini;S Wirtz;A Nikolaev

  • Regulation of homeostasis and inflammation in the intestine.

    Thomas T. MacDonald;Ivan Monteleone;Massimo Claudio Fantini;Giovanni Monteleone

  • Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

    Massimo C Fantini;Christoph Becker;Ingrid Tubbe;Alexei Nikolaev

  • Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease.

    Stefania Vetrano;Maria Rescigno;Maria Rosaria Cera;Carmen Correale

  • In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy

    C Becker;M C Fantini;S Wirtz;A Nikolaev

  • Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells

    Sabine Dominitzki;Massimo C. Fantini;Clemens Neufert;Alexei Nikolaev

  • Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis

    Christoph Becker;Heike Dornhoff;Clemens Neufert;Massimo C. Fantini

  • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1.

    Clemens Neufert;Christoph Becker;Stefan Wirtz;Massimo C. Fantini

  • Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21

    Giovanni Monteleone;Roberta Caruso;Daniele Fina;Ilaria Peluso

  • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL–6 trans-signaling

    C Becker;MC Fantini;C Schramm;HA Lehr

Frequent Co-Authors

Giovanni Monteleone
Giovanni Monteleone University of Rome Tor Vergata
Francesco Pallone
Francesco Pallone University of Rome Tor Vergata
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Thomas T. MacDonald
Thomas T. MacDonald University of Southampton
Kwong Y. Tsang
Kwong Y. Tsang National Institutes of Health
Christoph Becker
Christoph Becker University of Erlangen-Nuremberg
Andrea Modesti
Andrea Modesti University of Rome Tor Vergata
Philip M. Arlen
Philip M. Arlen National Institutes of Health
Jeffrey Schlom
Jeffrey Schlom National Institutes of Health
Peter R. Galle
Peter R. Galle Johannes Gutenberg University of Mainz

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