World's Best Scientists 2026 revealed!

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Immunology

D-Index
113
Citations
40571
World Ranking
439
National Ranking
39

Medicine

D-Index
113
Citations
40739
World Ranking
5009
National Ranking
492

Overview

Thomas T. MacDonald is a researcher affiliated with Queen Mary University of London in the United Kingdom. Their work spans several interconnected fields, mainly focusing on medicine, biochemistry, genetics, molecular biology, immunology, and microbiology.

Their research contributions are concentrated particularly within the study of inflammatory bowel disease and related immunological and molecular mechanisms. Key topics in their work include:

  • Inflammatory Bowel Disease
  • Galectins and Cancer Biology
  • Protein Degradation and Inhibitors
  • Ubiquitin and Proteasome Pathways
  • Multiple Myeloma Research and Treatments
  • Psoriasis: Treatment and Pathogenesis
  • Whipple's Disease and Interleukins

MacDonald has published research in a variety of journals, reflecting a diverse range of biological and clinical topics. Frequent publication venues include:

  • Communications Biology
  • Nature Communications
  • Journal of Inflammation Research
  • Scientific Reports
  • APOPTOSIS

They have collaborated repeatedly with several coauthors, indicating ongoing partnerships in their scientific work. Frequent coauthors include:

  • Anna Vossenkämper
  • Antonio Di Sabatino
  • Pamela A. Haile
  • Bartholomew J. Votta
  • Allison M. Beal

Selected research papers illustrate the scope and scale of their contributions:

  • "Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2," 2020, Communications Biology
  • "Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy," 2022, Nature Communications
  • "Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies," 2020, Journal of Inflammation Research
  • "Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease," 2021, Scientific Reports
  • "BindingDB Entry 50008194: Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[," 2021, PubMed

Their work primarily addresses mechanisms underlying inflammatory and immune-mediated diseases using molecular biology techniques. This includes examining cytokine pathways, protein degradation mechanisms, and therapeutic antibody resistance relevant to clinical conditions such as ulcerative colitis and multiple myeloma.

Best Publications

  • Immunity, Inflammation, and Allergy in the Gut

    Thomas T. MacDonald;Giovanni Monteleone

  • Tumour necrosis factor alpha in stool as a marker of intestinal inflammation

    C.P. Braegger;S. Nicholls;S.H. Murch;T.T. MacDonald

  • Human Intestinal Barrier Function in Health and Disease.

    Julia König;Jerry Wells;Patrice D. Cani;Clara L. García-Ródenas

  • Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

    Giovanni Monteleone;Andrea Kumberova;Nicholas M. Croft;Catriona McKenzie

  • Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

    Emma J. Breese;Colin A. Michie;Stuart W. Nicholls;Simon H. Murch

  • Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

    Ivan Monteleone;Angelamaria Rizzo;Massimiliano Sarra;Giuseppe Sica

  • Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

    S H Murch;C P Braegger;J A Walker-Smith;T T MacDonald

  • Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.

    V De Simone;E Franzè;G Ronchetti;A Colantoni

  • Homeostasis of the Gut Barrier and Potential Biomarkers.

    Jerry M. Wells;Robert J. Brummer;Muriel Derrien;Thomas T. MacDonald

  • Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

    Jenny Epstein;Ian R. Sanderson;Thomas T. MacDonald

  • Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.

    T T MacDonald;P Hutchings;M Y Choy;S Murch

  • Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

    S H Murch;V A Lamkin;M O Savage;J A Walker-Smith

  • Citrobacter rodentium of mice and man

    Rosanna Mundy;Thomas T. MacDonald;Gordon Dougan;Gad Frankel

  • Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

    Shyam Prasad;Roberto Mingrino;Katri Kaukinen;Katherine L Hayes

  • Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease.

    J. M. E. Fell;M. Paintin;F. Arnaud-Battandier;R. M. Beattie

  • Can probiotics modulate human disease by impacting intestinal barrier function

    Peter A. Bron;Michiel Kleerebezem;Robert Jan Brummer;Patrice D. Cani

  • Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency

    Bernhard Egger;Mona Bajaj-Elliott;Thomas T. MacDonald;Roman Inglin

  • Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

    T T MacDonald;J Spencer

  • Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

    Philip A. Harris;Scott B. Berger;Jae U. Jeong;Rakesh Nagilla

  • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

    E Breese;C P Braegger;C J Corrigan;J A Walker-Smith

  • S1731 Differential Regulation of Interleukin-17 and Interferon-γ Production in Inflammatory Bowel Disease

    L. Rovedatti;T. Kudo;P. Biancheri;M. Sarra

Frequent Co-Authors

Giovanni Monteleone
Giovanni Monteleone University of Rome Tor Vergata
Francesco Pallone
Francesco Pallone University of Rome Tor Vergata
Gino Roberto Corazza
Gino Roberto Corazza University of Pavia
Massimo Fantini
Massimo Fantini Precision Biologics
Graham M. Lord
Graham M. Lord University of Manchester
Jo Spencer
Jo Spencer King's College London
Gad Frankel
Gad Frankel Imperial College London
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Gordon Dougan
Gordon Dougan University of Cambridge
Giovanna Lombardi
Giovanna Lombardi King's College London

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