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Immunology

D-Index
58
Citations
18701
World Ranking
3464
National Ranking
132

Overview

Giuseppe Penna is affiliated with the European Institute of Oncology in Italy. Their research spans several areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on molecular biology, immunology, oncology, physiology, and food science. The scientist has contributed extensively to the understanding of gut microbiota, cancer immunotherapy, immune cell function, and barrier structures, among other topics.

The main topics covered in their work include:

  • Gut microbiota and health
  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • Probiotics and Fermented Foods
  • Immunotherapy and Immune Responses
  • Barrier Structure and Function Studies
  • Diet and metabolism studies

Among Giuseppe Penna's recent academic papers are:

  • "Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth," 2020, Nature Microbiology
  • "Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver," 2021, Cancer Cell
  • "Identification of a choroid plexus vascular barrier closing during intestinal inflammation," 2021, Science
  • "Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1," 2021, Journal for ImmunoTherapy of Cancer
  • "Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I," 2023, Cancer Cell

Giuseppe Penna has frequently collaborated with several co-authors, including:

  • María Rescigno
  • Daniele Braga
  • Michela Lizier
  • Chiara Pozzi
  • Sara Carloni

The scientist has published often in venues such as:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Cancer Cell
  • Frontiers in Microbiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Pediatric Research

Overall, Giuseppe Penna's body of work integrates extensive studies on the gut microbiome's relationship to cancer and immunity, exploring mechanisms of immune evasion and response, as well as the structural and functional aspects of biological barriers relevant to disease progression and therapy.

Best Publications

  • 1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

    Giuseppe Penna;Luciano Adorini

  • Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

    Claudia Winzler;Patrizia Rovere;Maria Rescigno;Francesca Granucci

  • Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

    Raffaella M Gadaleta;Karel J van Erpecum;Bas Oldenburg;Ellen C L Willemsen

  • Control of autoimmune diseases by the vitamin D endocrine system.

    Luciano Adorini;Giuseppe Penna

  • A gut-vascular barrier controls the systemic dissemination of bacteria

    Ilaria Spadoni;Elena Zagato;Alice Bertocchi;Roberta Paolinelli

  • Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development.

    Juliette Mouries;Paola Brescia;Alessandra Silvestri;Ilaria Spadoni

  • Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

    S Trembleau;G Penna;E Bosi;A Mortara

  • Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.

    Giuseppe Penna;Andrea Roncari;Susana Amuchastegui;Kenn C. Daniel

  • Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

    Elisa Mazzini;Lucia Massimiliano;Giuseppe Penna;Maria Rescigno

  • Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver

    Alice Bertocchi;Sara Carloni;Paola Simona Ravenda;Giovanni Bertalot

  • 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells.

    Giuseppe Penna;Susana Amuchastegui;Nadia Giarratana;Kenn C. Daniel

  • Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells

    Giuseppe Penna;Silvano Sozzani;Luciano Adorini

  • Seminal Plasma Cytokines and Chemokines in Prostate Inflammation: Interleukin 8 as a Predictive Biomarker in Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Benign Prostatic Hyperplasia

    Giuseppe Penna;Nicola Mondaini;Susana Amuchastegui;Selene Degli Innocenti

  • Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

    Katerina Tsilingiri;Theolis Barbosa;Giuseppe Penna;Flavio Caprioli

  • The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

    Lars Rogge;Daniele D’Ambrosio;Mauro Biffi;Giuseppe Penna

  • The control of T cell responses by dendritic cell subsets.

    Steven D Reid;Giuseppe Penna;Luciano Adorini

  • Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

    Francesca Aloisi;Francesco Ria;Giuseppe Penna;Luciano Adorini

  • Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.

    B. Fibbi;G. Penna;A. Morelli;L. Adorini

  • IL-12 Production by Central Nervous System Microglia is Inhibited by Astrocytes

    F Aloisi;G Penna;J Cerase;B Menéndez Iglesias

  • Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells.

    Giuseppe Penna;Marisa Vulcano;Silvano Sozzani;Luciano Adorini

  • Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases.

    Luciano Adorini;Giuseppe Penna;Nadia Giarratana;Milan Uskokovic

Frequent Co-Authors

Luciano Adorini
Luciano Adorini Intercept Pharmaceuticals (United States)
Maria Rescigno
Maria Rescigno Humanitas University
Mario Maggi
Mario Maggi University of Florence
Silvia Gregori
Silvia Gregori Vita-Salute San Raffaele University
Francesca Aloisi
Francesca Aloisi Istituto Superiore di Sanità
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome
Milan R. Uskokovic
Milan R. Uskokovic Roche (Switzerland)
Giuseppe Viale
Giuseppe Viale University of Milan
Pier Paolo Di Fiore
Pier Paolo Di Fiore University of Milan
Maurice K. Gately
Maurice K. Gately Roche (Switzerland)

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