Donald Kufe focuses on Molecular biology, Cancer research, Cell biology, Apoptosis and Immunology. His study in Molecular biology is interdisciplinary in nature, drawing from both DNA, DNA damage and Protein kinase C, Protein kinase A, Phosphorylation. The various areas that Donald Kufe examines in his Cancer research study include Tumor necrosis factor alpha, Cell culture, Ionizing radiation, MUC1 and Signal transduction.
Donald Kufe focuses mostly in the field of Signal transduction, narrowing it down to topics relating to Kinase and, in certain cases, Tyrosine kinase. His studies in Cell biology integrate themes in fields like Oxidative stress, Bcl-xL, Gene product and Heat shock protein. His Immunology study combines topics from a wide range of disciplines, such as Cytotoxic T cell and Radiation therapy.
Donald Kufe mostly deals with Cancer research, Molecular biology, Immunology, Cell biology and MUC1. He has researched Cancer research in several fields, including Tumor necrosis factor alpha, Apoptosis, Cancer and Signal transduction. His Molecular biology research includes themes of Cell culture, Gene expression, Biochemistry, DNA and Protein kinase C.
His Cell biology study frequently draws connections between related disciplines such as DNA damage. His work deals with themes such as Cancer cell, Breast cancer and Downregulation and upregulation, which intersect with MUC1. His research investigates the connection between Antigen and topics such as Monoclonal antibody that intersect with issues in Pathology.
His primary scientific interests are in Cancer research, MUC1, Immunology, Downregulation and upregulation and Gene silencing. His Cancer research study integrates concerns from other disciplines, such as T cell, Immune system and Cancer. He interconnects Cell culture, Protein kinase B, Cancer cell, Molecular biology and Drug resistance in the investigation of issues within MUC1.
His research in Molecular biology tackles topics such as Signal transduction which are related to areas like Cell growth and Kinase. His Immunology research incorporates elements of In vivo and Myeloid-derived Suppressor Cell. His Downregulation and upregulation study combines topics from a wide range of disciplines, such as Apoptosis, Transcription factor, PD-L1 and Breast cancer, Triple-negative breast cancer.
His primary areas of investigation include Cancer research, MUC1, Downregulation and upregulation, Gene silencing and Molecular biology. His Cancer research study incorporates themes from Cell growth, Apoptosis, PD-L1, Signal transduction and Epigenetics. His MUC1 study combines topics in areas such as Cell culture, In vitro, Cancer cell, Transmembrane protein and Intracellular.
Donald Kufe combines subjects such as Protein kinase B and Triple-negative breast cancer with his study of Downregulation and upregulation. His studies deal with areas such as TCF4, SKBR3, microRNA, Breast cancer and Regulation of gene expression as well as Gene silencing. Donald Kufe regularly links together related areas like Colorectal cancer in his Molecular biology studies.
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Mucins in cancer: function, prognosis and therapy.
Donald W. Kufe.
Nature Reviews Cancer (2009)
Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation
David H. Gorski;Michael A. Beckett;Nora T. Jaskowiak;Douglas P. Calvin.
Cancer Research (1999)
Combined effects of angiostatin and ionizing radiation in antitumour therapy
Helena J. Mauceri;Nader N. Hanna;Michael A. Beckett;David H. Gorski.
Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells.
Jlanlin Gong;Dongshu Chen;Masahiro Kashiwaba;Donald Kufe.
Nature Medicine (1997)
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
Zhi-Min Yuan;Hisashi Shioya;Takatoshi Ishiko;Xiangao Sun.
Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90
Pramod Pandey;Ayman Saleh;Atsuko Nakazawa;Shailendra Kumar.
The EMBO Journal (2000)
Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors.
Donald Kufe;Giorgio Inghirami;Miyako Abe;Daniel Hayes.
Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents
Surender Kharbanda;Ruibao Ren;Pramod Pandey;Timothy D. Shafman.
Interaction between ATM protein and c-Abl in response to DNA damage
T Shafman;K K Khanna;P Kedar;K Spring.
Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
Tariq Ghayur;Margaret Hugunin;Robert V. Talanian;Sheldon Ratnofsky.
Journal of Experimental Medicine (1996)
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