D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 87 Citations 29,351 261 World Ranking 6760 National Ranking 3720

Research.com Recognitions

Awards & Achievements

2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • DNA

William Plunkett mainly investigates Leukemia, Chronic lymphocytic leukemia, Biochemistry, Internal medicine and Cancer research. The concepts of his Leukemia study are interwoven with issues in Myeloid, Reactive oxygen species and Refractory. His Chronic lymphocytic leukemia research incorporates themes from Myeloid Cell Leukemia Sequence 1 Protein and Programmed cell death.

His Biochemistry study integrates concerns from other disciplines, such as Molecular biology and Deoxycytidine kinase. William Plunkett has researched Internal medicine in several fields, including Gastroenterology, Surgery and Oncology. His studies deal with areas such as Cyclin-dependent kinase 9, Apoptosis, Immunology, Histone H1 and Chromatin remodeling as well as Cancer research.

His most cited work include:

  • Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer (2202 citations)
  • Early Results of a Chemoimmunotherapy Regimen of Fludarabine, Cyclophosphamide, and Rituximab As Initial Therapy for Chronic Lymphocytic Leukemia (857 citations)
  • Action of 2',2'-difluorodeoxycytidine on DNA synthesis. (746 citations)

What are the main themes of his work throughout his whole career to date?

William Plunkett mostly deals with Leukemia, Internal medicine, Cancer research, Chronic lymphocytic leukemia and Fludarabine. His biological study spans a wide range of topics, including Myeloid and Pharmacology. He combines subjects such as Gastroenterology, Surgery and Oncology with his study of Internal medicine.

His Cancer research study also includes

  • Apoptosis together with Molecular biology,
  • DNA damage that intertwine with fields like DNA replication and Sapacitabine. His study explores the link between Molecular biology and topics such as Cell culture that cross with problems in Biochemistry. His Fludarabine research incorporates elements of Regimen, Cladribine and Rituximab.

He most often published in these fields:

  • Leukemia (27.65%)
  • Internal medicine (26.61%)
  • Cancer research (22.22%)

What were the highlights of his more recent work (between 2012-2021)?

  • Cancer research (22.22%)
  • Chronic lymphocytic leukemia (21.96%)
  • Internal medicine (26.61%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cancer research, Chronic lymphocytic leukemia, Internal medicine, Cytarabine and Ibrutinib. His Cancer research research is multidisciplinary, relying on both Leukemia, Immunology, Histone deacetylase, DNA repair and Sapacitabine. His research in Chronic lymphocytic leukemia intersects with topics in Cancer, Cytotoxic T cell, Kinase and eIF4A.

His Internal medicine study combines topics in areas such as Gastroenterology, Surgery and Oncology. His work carried out in the field of Cytarabine brings together such families of science as Phases of clinical research, DNA damage and Transplantation. His work deals with themes such as Chemoimmunotherapy, Rituximab and [email protected], which intersect with Fludarabine.

Between 2012 and 2021, his most popular works were:

  • Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia (296 citations)
  • Ibrutinib and venetoclax for first-line treatment of CLL (160 citations)
  • Transport properties of pancreatic cancer describe gemcitabine delivery and response (122 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • DNA

Internal medicine, Chronic lymphocytic leukemia, Cancer research, Ibrutinib and Leukemia are his primary areas of study. As part of the same scientific family, he usually focuses on Internal medicine, concentrating on Oncology and intersecting with Deoxycytidine, Gemcitabine and Pancreatic cancer. His research in Chronic lymphocytic leukemia tackles topics such as Surgery which are related to areas like Rituximab.

William Plunkett interconnects Chemotherapy, Cyclin-dependent kinase, Immunology, KRAS and Adipose tissue in the investigation of issues within Cancer research. The various areas that William Plunkett examines in his Leukemia study include Cyclin-dependent kinase 9, Tyrosine kinase, Histone deacetylase, Myeloid leukemia and Gene silencing. His Fludarabine research includes themes of Gastroenterology, Cytarabine and Chemoimmunotherapy.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Kenneth P. Olive;Michael A. Jacobetz;Christian J. Davidson;Aarthi Gopinathan;Aarthi Gopinathan.
Science (2009)

2850 Citations

Early Results of a Chemoimmunotherapy Regimen of Fludarabine, Cyclophosphamide, and Rituximab As Initial Therapy for Chronic Lymphocytic Leukemia

Michael J. Keating;Susan O'Brien;Maher Albitar;Susan Lerner.
Journal of Clinical Oncology (2005)

1238 Citations

Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

Peng Huang;Sherri Chubb;Sherri Chubb;Larry W. Hertel;Gerald B. Grindey.
Cancer Research (1991)

1174 Citations

Superoxide dismutase as a target for the selective killing of cancer cells

Peng Huang;Li Feng;Elizabeth A. Oldham;Michael J. Keating.
Nature (2000)

1091 Citations

Gemcitabine : metabolism, mechanisms of action, and self-potentiation

W. Plunkett;Peng Huang;Yi-Zheng Xu;V. Heinemann.
Seminars in Oncology (1995)

985 Citations

Comparison of the Cellular Pharmacokinetics and Toxicity of 2′,2′-Difluorodeoxycytidine and 1-β-d-Arabinofuranosylcytosine

Volker Heinemann;Larry W. Hertel;Gerald B. Grindey;William K Plunkett.
Cancer Research (1988)

765 Citations

Fludarabine: a new agent with major activity against chronic lymphocytic leukemia

M. J. Keating;Hagop M Kantarjian;M. Talpaz;J. Redman.
Blood (1989)

695 Citations

Inhibition of Mitochondrial Respiration A NOVEL STRATEGY TO ENHANCE DRUG-INDUCED APOPTOSIS IN HUMAN LEUKEMIA CELLS BY A REACTIVE OXYGEN SPECIES-MEDIATED MECHANISM

Helene Pelicano;Li Feng;Yan Zhou;Jennifer S. Carew.
Journal of Biological Chemistry (2003)

642 Citations

Randomized Phase II Comparison of Dose-Intense Gemcitabine: Thirty-Minute Infusion and Fixed Dose Rate Infusion in Patients With Pancreatic Adenocarcinoma

Margaret Tempero;William Plunkett;Veronique Ruiz Van Haperen;John Hainsworth.
Journal of Clinical Oncology (2003)

579 Citations

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.

V. Heinemann;Yi-Zheng Xu;S. Chubb;A. Sen.
Molecular Pharmacology (1990)

474 Citations

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