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Mark X. Sliwkowski

Mark X. Sliwkowski

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
45666
World Ranking
4668
National Ranking
2261

Overview

Mark X. Sliwkowski is a researcher affiliated with Genentech in the United States, focusing primarily on medicine with a specialization in oncology and radiology, nuclear medicine, and imaging.

The scientist's recent publication record includes work on HER2-directed therapies in cancer treatment. Their most notable recent paper is titled "The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results," published in 2024 in Nature Communications. This paper has received citations in the field.

The main fields of study for Mark X. Sliwkowski are medicine, with a total of three publications. Subfields include oncology, which accounts for two publications, and radiology, nuclear medicine, and imaging, with one publication.

Key research topics explored include:

  • HER2/EGFR in Cancer Research
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer Treatment and Pharmacology

Frequent coauthors with whom they have collaborated include:

  • Gail D. Lewis Phillips
  • Guangmin Li
  • Jun Guo
  • Shang-Fan Yu
  • Carter T. Fields

Mark X. Sliwkowski's research has been published in venues such as:

  • Nature Communications

Best Publications

  • Untangling the ErbB signalling network

    Yosef Yarden;Mark X. Sliwkowski

  • Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

    Gail D. Lewis Phillips;Guangmin Li;Debra L. Dugger;Lisa M. Crocker

  • Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.

    Jennifer Stamos;Mark X. Sliwkowski;Charles Eigenbrot

  • Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

    Jagath R Junutula;Helga Raab;Suzanna Clark;Sunil Bhakta

  • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

    Matthew C Franklin;Kendall D Carey;Felix F Vajdos;Daniel J Leahy

  • Identification of heregulin, a specific activator of p185erbB2.

    William E. Holmes;Mark X. Sliwkowski;Robert W. Akita;William J. Henzel

  • An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

    Antony W. Burgess;Hyun Soo Cho;Hyun Soo Cho;Charles Eigenbrot;Kathryn M. Ferguson

  • conjugado de anticorpo-droga, composição farmacêutica, artigo de manufatura e uso de um conjugado de anticorpo-droga

    Allen J Ebens;Brian E Toki;Mark X Sliwkowski;Paul Polakis

  • Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth.

    David B Agus;Robert W Akita;William D Fox;Gail D Lewis

  • Treatment of HER2-positive breast cancer: current status and future perspectives

    Carlos L. Arteaga;Mark X. Sliwkowski;C. Kent Osborne;Edith A. Perez

  • Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

    Ben-Quan Shen;Keyang Xu;Luna Liu;Helga Raab

  • Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

    Sliwkowski Mx;Lofgren Ja;Lewis Gd;Hotaling Te

  • Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

    Teemu T. Junttila;Robert W. Akita;Kathryn Parsons;Carter Fields

  • Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

    M.X. Sliwkowski;G. Schaefer;R.W. Akita;J.A. Lofgren

  • HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

    Pietras Rj;Arboleda J;Reese Dm;Wongvipat N

  • Inhibitory effects of combinations of HER-2/ neu antibody and chemotherapeutic agents used for treatment of human breast cancers

    Mark Pegram;Sheree Hsu;Gail Lewis;Richard Pietras

  • A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy

    Si Tuen Lee-Hoeflich;Lisa Crocker;Evelyn Yao;Thinh Pham

  • Phase I Study of Trastuzumab-DM1, an HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer

    Ian E. Krop;Muralidhar Beeram;Shanu Modi;Suzanne F. Jones

  • Antibody therapeutics in cancer.

    Mark X. Sliwkowski;Ira Mellman

  • Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.

    Michael F. Press;Malcolm C. Pike;Victoria R. Chazin;Gene Hung

Frequent Co-Authors

Paul Polakis
Paul Polakis Genentech
Peter D. Senter
Peter D. Senter Seattle Genetics (United States)
Germaine Fuh
Germaine Fuh Genentech
Ira Mellman
Ira Mellman Parker Institute for Cancer Immunotherapy

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