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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
19286
World Ranking
14166
National Ranking
5972

Overview

Ryan J. Watts is affiliated with Denali Therapeutics in the United States. Their research is primarily situated within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on subfields such as Neurology, Physiology, Molecular Biology, Oncology, and Cell Biology.

The scientist's work addresses several main topics, including:

  • Lysosomal Storage Disorders Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Drug Transport and Resistance Mechanisms
  • Cellular transport and secretion
  • RNA Interference and Gene Delivery
  • Amyotrophic Lateral Sclerosis Research

Their recent publications illustrate activity in neurological and molecular therapeutic research. Key papers include:

  • "TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge," published in Neuron in 2020
  • "Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys," published in Science Translational Medicine in 2020
  • "A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models," published in Nature Neuroscience in 2023
  • "Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic," published in Cell in 2021
  • "Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice," published in Science Translational Medicine in 2020

Watts frequently publishes in several scientific journals and platforms. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Cell
  • Nature Communications
  • Cureus

The collaboration network of this scientist includes frequent co-authors such as Timothy Earr, Joseph W. Lewcock, Mark S. Dennis, Michelle E. Pizzo, and Do Jin Kim. These professional relationships indicate a consistent collaborative approach within their research environment.

Best Publications

  • A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

    Thorlakur Jonsson;Jasvinder K. Atwal;Stacy Steinberg;Jon Snaedal

  • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

    John Ridgway;Gu Zhang;Yan Wu;Scott Stawicki

  • Therapeutic antibody targeting of individual Notch receptors

    Yan Wu;Carol Cain-Hom;Lisa Choy;Thijs J. Hagenbeek

  • Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

    Y. Joy Yu;Yin Zhang;Margaret Kenrick;Kwame Hoyte

  • Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

    Qi Pan;Yvan Chanthery;Wei-Ching Liang;Scott Stawicki

  • Engaging neuroscience to advance translational research in brain barrier biology

    Edward A. Neuwelt;Björn Bauer;Christoph Fahlke;Gert Fricker

  • The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

    Jennifer M. MacDonald;Margaret G. Beach;Ermelinda Porpiglia;Amy E. Sheehan

  • TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

    Alicia A. Nugent;Karin Lin;Bettina van Lengerich;Steve Lianoglou

  • Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system.

    Ryan J Watts;Eric D Hoopfer;Liqun Luo

  • Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

    Maresa Caunt;Judy Mak;Wei-Ching Liang;Scott Stawicki

  • An Effector-Reduced Anti-β-Amyloid (Aβ) Antibody with Unique Aβ Binding Properties Promotes Neuroprotection and Glial Engulfment of Aβ

    Oskar Adolfsson;Maria Pihlgren;Nicolas Toni;Yvan Varisco

  • Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration

    Qiwei Zhai;Jing Wang;Anna Kim;Qing Liu

  • VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

    Fan Zhang;Zhongshu Tang;Xu Hou;Johan Lennartsson

  • Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

    Y. Joy Yu;Jasvinder K. Atwal;Yin Zhang;Raymond K. Tong

  • Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

    Nga Bien-Ly;Y. Joy Yu;Daniela Bumbaca;Justin Elstrott

  • Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

    Reina N. Fuji;Michael Flagella;Miriam Baca;Marco A. S. Baptista

  • Wlds Protection Distinguishes Axon Degeneration following Injury from Naturally Occurring Developmental Pruning

    Eric D. Hoopfer;Todd McLaughlin;Ryan J. Watts;Ryan J. Watts;Oren Schuldiner

  • A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

    Jasvinder K. Atwal;Yongmei Chen;Cecilia Chiu;Deborah L. Mortensen

  • Neuropilin-1 Binds to VEGF121 and Regulates Endothelial Cell Migration and Sprouting

    Qi Pan;Yvan Chathery;Yan Wu;Nisha Rathore

  • Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.

    Megan Lo;Hok Seon Kim;Raymond K. Tong;Travis W. Bainbridge

Frequent Co-Authors

Marc Tessier-Lavigne
Marc Tessier-Lavigne Xaira Therapeutics
Liqun Luo
Liqun Luo Stanford University
Giuseppe Astarita
Giuseppe Astarita Georgetown University
Gilbert Di Paolo
Gilbert Di Paolo Columbia University Medical Center
Anne Eichmann
Anne Eichmann Yale University
Robert R. Graham
Robert R. Graham Maze Therapeutics
Timothy W. Behrens
Timothy W. Behrens Xaira Therapeutics
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai

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