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Neuroscience

D-Index
63
Citations
16606
World Ranking
3365
National Ranking
307

Overview

Michael P. Coleman is affiliated with the University of Cambridge in United Kingdom. Their research predominantly spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience, with specific concentration on Molecular Biology, Physiology, Neurology, Geriatrics and Gerontology, and Cellular and Molecular Neuroscience.

The main topics of work addressed by Coleman encompass Sirtuins and Resveratrol in Medicine, Calcium signaling and nucleotide metabolism, Alzheimer's disease research and treatments, Signaling Pathways in Disease, Mitochondrial Function and Pathology, Neuroinflammation and Neurodegeneration Mechanisms, and Amyotrophic Lateral Sclerosis Research.

Recent notable publications authored or co-authored by Coleman include:

  • Programmed axon degeneration: from mouse to mechanism to medicine, 2020, Nature reviews. Neuroscience
  • Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors, 2020, JCI Insight
  • SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by multiple physiologically relevant NAD metabolites, 2022, iScience
  • Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders, 2021, eLife
  • Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity, 2020, Nature Chemical Biology

Frequent co-authors collaborating with Coleman include Jonathan Gilley, Andrea Loreto, Giuseppe Orsomando, Elisa Merlini, and Peter Arthur-Farraj.

Coleman's work appears in several publication venues with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Neurotherapeutics, Nature Communications, eLife, and Nature reviews. Neuroscience.

Best Publications

  • Axon degeneration mechanisms: commonality amid diversity

    Michael Coleman

  • Neuronal Cell Death.

    Michael Fricker;Abby Miriam Tolkovsky;Vilmante Borutaite;Michael Philip Coleman

  • Wallerian degeneration: an emerging axon death pathway linking injury and disease

    Laura Conforti;Jonathan Gilley;Michael P. Coleman

  • dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

    Jeannette M. Osterloh;Jing Yang;Timothy M. Rooney;A. Nicole Fox

  • Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

    T G Mack;M Reiner;B Beirowski;W Mi

  • Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

    Jonathan Gilley;Michael P. Coleman

  • Axon pathology in neurological disease: a neglected therapeutic target.

    Michael P Coleman;V.Hugh Perry

  • Wallerian Degeneration, WldS, and Nmnat

    Michael P. Coleman;Marc R. Freeman

  • NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

    Shane Horsefield;Hayden Burdett;Xiaoxiao Zhang;Xiaoxiao Zhang;Mohammad K. Manik

  • The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves

    Bogdan Beirowski;Robert Adalbert;Robert Adalbert;Diana Wagner;Daniela S Grumme

  • Traumatic Axonal Injury: Mechanisms and Translational Opportunities

    Ciaran S. Hill;Michael P. Coleman;David K. Menon

  • Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease.

    Anna Ferri;Joshua R. Sanes;Michael P. Coleman;Jeanette M. Cunningham

  • TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.

    Matthew A. White;Matthew A. White;Eosu Kim;Eosu Kim;Amanda Duffy;Robert Adalbert

  • Programmed axon degeneration: from mouse to mechanism to medicine.

    Michael P. Coleman;Ahmet Höke

  • The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.

    Mohtashem Samsam;Weiqian Mi;Carsten Wessig;Jürgen Zielasek

  • Review: Axon pathology in age-related neurodegenerative disorders.

    R. Adalbert;M. P. Coleman

  • An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse.

    Unknown

  • Neuronal death: where does the end begin?

    Laura Conforti;Robert Adalbert;Michael P. Coleman

  • Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies

    Robert Adalbert;Antal Nogradi;Elisabetta Babetto;Lucie Janeckova

  • Mitochondria as a central sensor for axonal degenerative stimuli

    Felipe A. Court;Michael P. Coleman

  • Autophagy in axonal and dendritic degeneration

    Yi Yang;Yi Yang;Michael Coleman;Lihui Zhang;Xiaoxiang Zheng

Frequent Co-Authors

Richard R. Ribchester
Richard R. Ribchester University of Edinburgh
Brian J. Staskawicz
Brian J. Staskawicz University of California, Berkeley
Peter N. Dodds
Peter N. Dodds Commonwealth Scientific and Industrial Research Organisation
Simon Andrews
Simon Andrews Babraham Institute
Lisa M. Saksida
Lisa M. Saksida University of Western Ontario
Timothy J. Bussey
Timothy J. Bussey University of Western Ontario
Ziv Gan-Or
Ziv Gan-Or McGill University
Oliver Peters
Oliver Peters German Center for Neurodegenerative Diseases
Marc R. Freeman
Marc R. Freeman Oregon Health & Science University
Zsuzsanna Izsvák
Zsuzsanna Izsvák Max Delbrück Center for Molecular Medicine

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