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Neuroscience

D-Index
46
Citations
8501
World Ranking
6674
National Ranking
2900

Overview

Nicholas M. Kanaan is affiliated with Michigan State University in the United States. The primary focus of their research lies in the intersection of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to related subfields such as Physiology, Molecular Biology, Neurology, Cellular and Molecular Neuroscience, and Pharmacology.

Their scholarly work centers on topics including Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, neuroinflammation and neurodegeneration mechanisms, RNA research and splicing, cholinesterase and neurodegenerative diseases, RNA modifications and cancer, as well as mitochondrial function and pathology.

Published papers by Nicholas M. Kanaan span key journals and platforms. Notable recent publications include:

  • Liquid-liquid phase separation induces pathogenic tau conformations in vitro, 2020, Nature Communications
  • Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy, 2021, Molecular Cell
  • TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau, 2021, Proceedings of the National Academy of Sciences
  • Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease, 2022, Human Molecular Genetics
  • Tau: A Signaling Hub Protein, 2021, Frontiers in Molecular Neuroscience

Nicholas M. Kanaan frequently collaborates with several coauthors, with whom they have multiple joint publications. These include Tessa Grabinski, Benjamin Wolozin, Benjamin Combs, Mohammed M. Alhadidy, and Kelly N. Dubois.

The distribution of their research dissemination is evident through frequent publications in venues such as bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Acta Neuropathologica Communications, SSRN Electronic Journal, and Frontiers in Molecular Neuroscience.

Best Publications

  • Tau Kinetics in Neurons and the Human Central Nervous System

    Chihiro Sato;Nicolas R. Barthélemy;Kwasi G. Mawuenyega;Bruce W. Patterson

  • Axonal Transport Defects in Neurodegenerative Diseases

    Gerardo A. Morfini;Matthew Burns;Lester I. Binder;Nicholas M. Kanaan

  • Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

    Timothy J. Collier;Nicholas M. Kanaan;Jeffrey H. Kordower

  • Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

    Katrina L. Paumier;Kelvin C. Luk;Fredric P. Manfredsson;Nicholas M. Kanaan

  • Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

    Kristina R. Patterson;Christine Remmers;Yifan Fu;Sarah Brooker

  • Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

    Nicholas M. Kanaan;Gerardo A. Morfini;Gerardo A. Morfini;Nichole E. LaPointe;Gustavo F. Pigino;Gustavo F. Pigino

  • Aging and Parkinson's disease: Different sides of the same coin?

    Timothy J. Collier;Nicholas M. Kanaan;Jeffrey H. Kordower

  • Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

    M. Fá;D. Puzzo;D. Puzzo;R. Piacentini;Agnieszka Staniszewski

  • Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

    Daniel J. Apicco;Peter E. A. Ash;Brandon Maziuk;Chelsey LeBlang

  • Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

    Nicholas M. Kanaan;Gustavo F. Pigino;Scott T. Brady;Orly Lazarov

  • Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

    Megan F Duffy;Timothy J Collier;Joseph R Patterson;Christopher J Kemp

  • Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

    Lulu Jiang;Weiwei Lin;Cheng Zhang;Peter E.A. Ash

  • Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

    Jeffrey H. Kordower;Nicholas M. Kanaan;Yaping Chu;Rangasamy Suresh Babu

  • Erratum: Tau Kinetics in Neurons and the Human Central Nervous System (Neuron (2018) 97(6) (1284–1298.e7)(S0896627318301363)(10.1016/j.neuron.2018.02.015))

    Chihiro Sato;Nicolas R. Barthélemy;Kwasi G. Mawuenyega;Bruce W. Patterson

  • Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

    David J. Koss;Glynn Jones;Anna Cranston;Heidi Gardner

  • Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

    Kristina R. Patterson;Sarah M. Ward;Benjamin Combs;Kellen Voss

  • Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

    Laurel Vana;Nicholas M. Kanaan;Isabella C. Ugwu;Joanne Wuu

  • Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

    Nicholas M. Kanaan;Gerardo Morfini;Gerardo Morfini;Gustavo Pigino;Gustavo Pigino;Nichole E. LaPointe

  • A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures.

    Tessa M. Grabinski;Andrew Kneynsberg;Fredric P. Manfredsson;Nicholas M. Kanaan

  • Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.

    Nicholas M. Kanaan;Kristine Cox;Victor E. Alvarez;Thor D. Stein

  • Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability.

    Nicholas M. Kanaan;Jeffrey H. Kordower;Timothy J. Collier

Frequent Co-Authors

Caryl E. Sortwell
Caryl E. Sortwell Michigan State University
Jeffrey H. Kordower
Jeffrey H. Kordower Arizona State University
Jack W. Lipton
Jack W. Lipton Michigan State University
Kathy Steece-Collier
Kathy Steece-Collier Michigan State University
Scott E. Counts
Scott E. Counts Michigan State University
Stephen D. Ginsberg
Stephen D. Ginsberg Nathan Kline Institute for Psychiatric Research
Randall J. Bateman
Randall J. Bateman Washington University in St. Louis
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania

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