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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
12410
World Ranking
11988
National Ranking
5144

Overview

Bradley E. Britigan is affiliated with the University of Nebraska Medical Center in the United States. Their research primarily focuses on Biochemistry, Genetics and Molecular Biology with significant contributions to subfields including Molecular Biology, Molecular Medicine, Immunology, Epidemiology, and Infectious Diseases.

The main topics covered in their work include:

  • Antibiotic Resistance in Bacteria
  • Mycobacterium research and diagnosis
  • Bacterial biofilms and quorum sensing
  • Nanoplatforms for cancer theranostics
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Immune Response and Inflammation
  • S100 Proteins and Annexins

Britigan has authored several papers across reputable journals. Notable recent publications include:

  • "Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial Species by Targeting Different Aspects of Iron/Heme Metabolism" (2020, ACS Infectious Diseases)
  • "Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma" (2021, Cancers)
  • "Nanoparticulate β-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium" (2021, ACS Infectious Diseases)
  • "Antimicrobial Activity of Gallium(III) Compounds: Pathogen-Dependent Targeting of Multiple Iron/Heme-Dependent Biological Processes" (2024, Current Issues in Molecular Biology)
  • "Combining Gallium Protoporphyrin and Gallium Nitrate Enhances In Vitro and In Vivo Efficacy against Pseudomonas aeruginosa: Role of Inhibition of Bacterial Antioxidant Enzymes and Resultant Increase in Cytotoxic Reactive Oxygen Species" (2022, ACS Infectious Diseases)

Frequent co-authors collaborating with Britigan include:

  • Prabagaran Narayanasamy
  • Seoung-ryoung Choi
  • Bryan N. Becker
  • Lars Berglund
  • Robert D. Blank

The venues where Britigan has most commonly published are:

  • Translational Research (8 publications)
  • ACS Infectious Diseases (5 publications)
  • UNC Libraries (5 publications)
  • Bioorganic & Medicinal Chemistry Letters (2 publications)
  • Advanced Therapeutics (2 publications)

Best Publications

  • The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

    Yukihiro Kaneko;Matthew Thoendel;Oyebode Olakanmi;Bradley E. Britigan

  • Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi

    Kira R. Gantt;Todd L. Goldman;Michael L. McCormick;Michael L. McCormick;Melissa A. Miller

  • Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

    Christopher H. Goss;Yukihiro Kaneko;Lisa Khuu;Gail D. Anderson

  • Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

    Carroll L. Ramos;Sovitj Pou;Bradley E. Britigan;Myron S. Cohen

  • Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages

    Oyebode Olakanmi;Bradley E. Britigan;Larry S. Schlesinger

  • Pseudomonas Pyocyanin Increases Interleukin-8 Expression by Human Airway Epithelial Cells

    Gerene M. Denning;Laura A. Wollenweber;Michelle A. Railsback;Charles D. Cox

  • Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells

    Yunxia Q. O'Malley;Krzysztof J. Reszka;Douglas R. Spitz;Gerene M. Denning

  • Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury.

    B E Britigan;T L Roeder;G T Rasmussen;D M Shasby;D M Shasby

  • Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses.

    Maher Y. Abdalla;Iman M. Ahmad;Douglas R. Spitz;Warren N. Schmidt

  • Modulation of lung epithelial functions by Pseudomonas aeruginosa

    Gee W. Lau;Daniel J. Hassett;Bradley E. Britigan;Bradley E. Britigan

  • Detection of the production of oxygen-centered free radicals by human neutrophils using spin trapping techniques: a critical perspective.

    Bradley E. Britigan;Myron S. Cohen;Gerald M. Rosen

  • Lactoferrin Binds CpG-Containing Oligonucleotides and Inhibits Their Immunostimulatory Effects on Human B Cells

    Bradley E. Britigan;Troy S. Lewis;Mari Waldschmidt;Michael L. McCormick

  • Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools IMPACT OF INTERFERON-γ AND HEMOCHROMATOSIS

    Oyebode Olakanmi;Larry S. Schlesinger;Ambar Ahmed;Bradley E. Britigan;Bradley E. Britigan

  • Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin

    Bradley E. Britigan;George T. Rasmussen;Charles D. Cox

  • Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide

    Krzysztof J. Reszka;Yunxia O'Malley;Michael L. McCormick;Gerene M. Denning

  • Interaction of lactoferrin and lipopolysaccharide (LPS): effects on the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation.

    Myron S. Cohen;Jinghe Mao;Jinghe Mao;George T. Rasmussen;George T. Rasmussen;Jonathan S. Serody;Jonathan S. Serody

  • Pseudomonas pyocyanine alters calcium signaling in human airway epithelial cells

    Gerene M. Denning;Michelle A. Railsback;George T. Rasmussen;Charles D. Cox

  • The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells

    Yunxia Q. O'Malley;Krzysztof J. Reszka;George T. Rasmussen;Maher Y. Abdalla

  • Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi

    Melissa A. Miller;Stephen E. McGowan;Kira R. Gantt;Matthew Champion

  • Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages.

    Oyebode Olakanmi;Oyebode Olakanmi;Larry S. Schlesinger;Bradley E. Britigan;Bradley E. Britigan

Frequent Co-Authors

Garry R. Buettner
Garry R. Buettner University of Iowa
Gerald M. Rosen
Gerald M. Rosen University of Maryland, Baltimore
Larry S. Schlesinger
Larry S. Schlesinger Texas Biomedical Research Institute
Daniel J. Hassett
Daniel J. Hassett University of Cincinnati Medical Center
Mary E. Wilson
Mary E. Wilson University of California, San Francisco
Myron S. Cohen
Myron S. Cohen University of North Carolina at Chapel Hill
John B. Stokes
John B. Stokes University of Iowa
Douglas R. Spitz
Douglas R. Spitz University of Iowa
Joel V. Weinstock
Joel V. Weinstock Tufts Medical Center
Larry W. Oberley
Larry W. Oberley University of Iowa

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