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Immunology

D-Index
81
Citations
21174
World Ranking
1584
National Ranking
789

Overview

Larry S. Schlesinger is affiliated with the Texas Biomedical Research Institute in the United States. Their research primarily focuses on medicine, with a significant emphasis on immunology and microbiology. Within these fields, the scientist has extensively studied infectious diseases, immunology, molecular biology, epidemiology, and pulmonary and respiratory medicine.

The central topics addressed in their work include:

  • Tuberculosis Research and Epidemiology
  • SARS-CoV-2 and COVID-19 Research
  • Immune cells in cancer
  • COVID-19 Clinical Research Studies
  • Mycobacterium research and diagnosis
  • Long-Term Effects of COVID-19
  • Neonatal Respiratory Health Research

The scientist has published in several venues, with a notable presence in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Microbiology
  • The Journal of Immunology
  • UNC Libraries

Selected recent papers authored or co-authored by Larry S. Schlesinger include:

  • "Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice," 2020, Nature Communications
  • "Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets," 2020, Nature Microbiology
  • "IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection," 2021, Communications Biology
  • "Myeloid cell interferon responses correlate with clearance of SARS-CoV-2," 2022, Nature Communications
  • "Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their work include:

  • Jordi B. Torrelles
  • Eusondia Arnett
  • Deepak Kaushal
  • Joanne Turner
  • Andreu Garcia-Vilanova

Best Publications

  • Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors.

    L S Schlesinger

  • Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.

    L S Schlesinger;C G Bellinger-Kawahara;N R Payne;M A Horwitz

  • The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis

    Peter B. Kang;Abul K. Azad;Jordi B. Torrelles;Thomas M. Kaufman

  • Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages.

    L S Schlesinger;S R Hull;T M Kaufman

  • Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages.

    C D Gaynor;F X McCormack;D R Voelker;S E McGowan

  • Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.

    Fatai S. Oladunni;Jun-Gyu Park;Paula A. Pino;Olga Gonzalez

  • Macrophages in tuberculosis: friend or foe.

    Evelyn Guirado;Larry S. Schlesinger;Gilla Kaplan

  • Innate Immune Gene Polymorphisms in Tuberculosis

    Abul K. Azad;Wolfgang Sadee;Larry S. Schlesinger

  • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

    Murugesan V. S. Rajaram;Bin Ni;Jessica D. Morris;Michelle N. Brooks

  • Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease.

    Evelyn Guirado;Larry S. Schlesinger

  • Surfactant Protein D Binds to Mycobacterium tuberculosis Bacilli and Lipoarabinomannan via Carbohydrate-Lectin Interactions Resulting in Reduced Phagocytosis of the Bacteria by Macrophages1

    Ferguson Js;Voelker Dr;McCormack Fx;Schlesinger Ls

  • Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis.

    Fatoumata B. Sow;William C. Florence;Abhay R. Satoskar;Larry S. Schlesinger

  • Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization.

    Meenu Mishra;Matthew S. Byrd;Susan Sergeant;Abul K. Azad

  • Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor γ Linking Mannose Receptor Recognition to Regulation of Immune Responses

    Murugesan V. S. Rajaram;Michelle N. Brooks;Jessica D. Morris;Jordi B. Torrelles

  • Virulent Strains of Helicobacter pylori Demonstrate Delayed Phagocytosis and Stimulate Homotypic Phagosome Fusion in Macrophages

    Lee-Ann H. Allen;Larry S. Schlesinger;Byoung Kang

  • Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages

    Oyebode Olakanmi;Bradley E. Britigan;Larry S. Schlesinger

  • Exploitation of the Macrophage Mannose Receptor (CD206) in Infectious Disease Diagnostics and Therapeutics.

    Abul K. Azad;Murugesan V. S. Rajaram;Larry S. Schlesinger

  • Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophages.

    L S Schlesinger;T M Kaufman;S Iyer;S R Hull

  • Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors.

    Jordi B. Torrelles;Abul K. Azad;Larry S. Schlesinger

  • Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFN-gamma activation inhibits complement receptor function and phagocytosis of this bacterium.

    L S Schlesinger;M A Horwitz

  • Human Genetic Determinants of Viral Diseases.

    Adam D. Kenney;James A. Dowdle;Leonia Bozzacco;Leonia Bozzacco;Temet M. McMichael

  • Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

    Fatai S. Oladunni;Jun-Gyu Park;Paula Pino Tamayo;Olga Gonzalez

Frequent Co-Authors

John S. Gunn
John S. Gunn Nationwide Children's Hospital
Joanne Turner
Joanne Turner Texas Biomedical Research Institute
Bradley E. Britigan
Bradley E. Britigan University of Nebraska Medical Center
Wolfgang Sadee
Wolfgang Sadee The Ohio State University
Susheela Tridandapani
Susheela Tridandapani The Ohio State University
Ching-Shih Chen
Ching-Shih Chen The Ohio State University
Francis X. McCormack
Francis X. McCormack University of Cincinnati
Shabaana A. Khader
Shabaana A. Khader Washington University in St. Louis
Mark D. Wewers
Mark D. Wewers The Ohio State University
Avner Friedman
Avner Friedman The Ohio State University

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