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Biology and Biochemistry

D-Index
46
Citations
7096
World Ranking
18977
National Ranking
608

Overview

Paola Bruni is affiliated with the University of Florence in Italy and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans molecular biology, reproductive medicine, immunology, cell biology, and physiology.

The scientist's main research topics include:

  • Sphingolipid Metabolism and Signaling
  • Endometriosis Research and Treatment
  • Cellular Transport and Secretion
  • Reproductive System and Pregnancy
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Protein Tyrosine Phosphatases
  • Adenosine and Purinergic Signaling

Paola Bruni has contributed to several recent papers, some of which are the following:

  • Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis, 2022, Reproductive Sciences
  • Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β-induced fibrosis, 2020, Fertility and Sterility
  • Ferritin nanocomposites for the selective delivery of photosensitizing ruthenium-polypyridyl compounds to cancer cells, 2022, Inorganic Chemistry Frontiers
  • Role of sphingosine 1-phosphate signalling in tissue fibrosis, 2020, Cellular Signalling
  • Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway, 2020, Biochemical Pharmacology

The preferred venues for publishing include:

  • International Journal of Molecular Sciences (4 publications)
  • Fertility and Sterility (3 publications)
  • Cellular Signalling (3 publications)
  • The FASEB Journal (2 publications)
  • FEBS Journal (2 publications)

Collaborative research is a significant aspect of their work, with frequent coauthors including:

  • Chiara Donati (18 collaborations)
  • Francesca Cencetti (17 collaborations)
  • Caterina Bernacchioni (15 collaborations)
  • Felice Petraglia (9 collaborations)
  • Valentina Vannuzzi (6 collaborations)

Best Publications

  • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27 Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

    Giuseppe Viglietto;Maria Letizia Motti;Paola Bruni;Rosa Marina Melillo

  • Endothelial Nitric Oxide Synthase Activation by Tumor Necrosis Factor α Through Neutral Sphingomyelinase 2, Sphingosine Kinase 1, and Sphingosine 1 Phosphate Receptors: A Novel Pathway Relevant to the Pathophysiology of Endothelium

    Clara De Palma;Elisabetta Meacci;Cristiana Perrotta;Paola Bruni

  • PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.

    Paola Bruni;Angelo Boccia;Gustavo Baldassarre;Francesco Trapasso

  • Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

    Francesca Cencetti;Caterina Bernacchioni;Paola Nincheri;Chiara Donati

  • Isolation, physical mapping, and northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2.

    M. D’Esposito;N. A. Quaderi;A. Ciccodicola;P. Bruni

  • Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

    Gustavo Baldassarre;Barbara Belletti;Paola Bruni;Angelo Boccia

  • The β-Amyloid Precursor Protein APP Is Tyrosine-phosphorylated in Cells Expressing a Constitutively Active Form of the Abl Protoncogene

    Nicola Zambrano;Paola Bruni;Giuseppina Minopoli;Rosario Mosca

  • Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization.

    Giuseppe Viglietto;Annunciata Romano;Giovanni Manzo;Gennaro Chiappetta

  • Rat Protein Tyrosine Phosphatase η Suppresses the Neoplastic Phenotype of Retrovirally Transformed Thyroid Cells through the Stabilization of p27Kip1

    Francesco Trapasso;Rodolfo Iuliano;Angelo Boccia;Antonella Stella

  • Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

    Francesca Telese;Paola Bruni;Aldo Donizetti;Davide Gianni

  • Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor.

    Chiara Donati;Elisabetta Meacci;Francesca Nuti;Laura Becciolini

  • An Active Form of Sphingosine Kinase-1 Is Released in the Extracellular Medium as Component of Membrane Vesicles Shed by Two Human Tumor Cell Lines

    Salvatrice Rigogliuso;Chiara Donati;Donata Cassarà;Simona Taverna

  • Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum.

    Alessia Melani;Francesca Corti;Holger Stephan;Christa E. Müller

  • Fe65, a Ligand of the Alzheimer's β-Amyloid Precursor Protein, Blocks Cell Cycle Progression by Down-regulating Thymidylate Synthase Expression

    Paola Bruni;Giuseppina Minopoli;Tiziana Brancaccio;Maria Napolitano

  • Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia.

    G Viglietto;S Dolci;P Bruni;G Baldassarre

  • Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia

    Alessia Melani;Sara Cipriani;Maria Giuliana Vannucchi;Daniele Nosi

  • Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.

    Gustavo Baldassarre;Angelo Boccia;Paola Bruni;Claudia Sandomenico

  • Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: Role of S1P receptors

    Serena Calise;Sabrina Blescia;Francesca Cencetti;Caterina Bernacchioni

  • Relaxin in human decidua.

    Mario Bigazzi;Emma Nardi;Paola Bruni;Fabrizia Petrucci

  • Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels.

    Lucia Formigli;Elisabetta Meacci;Chiasa Sassoli;Flaminia Chellini

Frequent Co-Authors

Alfredo Fusco
Alfredo Fusco University of Naples Federico II
Giuseppe Viglietto
Giuseppe Viglietto Magna Graecia University
Antonino Zichichi
Antonino Zichichi University of Bologna
Lucia Formigli
Lucia Formigli University of Florence
Felicita Pedata
Felicita Pedata University of Florence
Joel Moss
Joel Moss National Institutes of Health
A. Contin
A. Contin University of Bologna
M. Derrick
M. Derrick Argonne National Laboratory
Erik L. Hewlett
Erik L. Hewlett University of Virginia
Massimo Santoro
Massimo Santoro University of Padua

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