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Biology and Biochemistry

D-Index
70
Citations
14052
World Ranking
7167
National Ranking
525

Overview

Rolf W. Hartmann is affiliated with the Helmholtz Centre for Infection Research in Germany. Their research spans several interconnected fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, Medicine, and Materials Science. These areas encompass more specialized subfields including Materials Chemistry, Molecular Biology, Organic Chemistry, Molecular Medicine, and Epidemiology.

The scientist's research topics cover a broad range of subjects such as crystallization and solubility studies, X-ray diffraction in crystallography, bacterial biofilms and quorum sensing, antibiotic resistance in bacteria, antimicrobial peptides and activities, pneumonia and respiratory infections, and inhalation and respiratory drug delivery.

Hartmann has contributed to multiple scientific publications, with frequent appearances in the following venues:

  • The Cambridge Structural Database
  • Advanced Science
  • Angewandte Chemie International Edition
  • Journal of Medicinal Chemistry
  • ChemMedChem

Frequent co-authors collaborating with Hartmann include:

  • Anna K. H. Hirsch
  • Lara Rosenberger
  • Carolina von Eßen
  • Anupam Khutia
  • Clemens Kühn

Among recent papers authored or co-authored by Hartmann are:

  • Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (2020, Angewandte Chemie International Edition)
  • A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (2021, Advanced Science)
  • N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases (2020, Journal of Medicinal Chemistry)
  • Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics (2020, Chemistry - A European Journal)
  • Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites (2020, Drug Metabolism and Disposition)

Best Publications

  • 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

    Sandrine Marchais-Oberwinkler;Claudia Henn;Gabriele Möller;Tobias Klein

  • Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

    Stefanie Wagner;Roman Sommer;Stefan Hinsberger;Cenbin Lu

  • Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.

    Noha Nafee;Ayman Husari;Christine K. Maurer;Cenbin Lu

  • Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones

    Rolf W. Hartmann;Christine Batzl

  • Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

    Cenbin Lu;Benjamin Kirsch;Christina Zimmer;Johannes C. de Jong

  • Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors

    Michael P Storz;Christine K Maurer;Christina Zimmer;Nathalie Wagner

  • Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

    Emmanuel Bey;Sandrine Marchais-Oberwinkler;Ruth Werth;Matthias Negri

  • Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases

    Rolf Hartmann;Ulrike Hille;Christina Zimmer;Carsten A. Vock

  • Tetrahydronaphthalenes: Influence of Heterocyclic Substituents on Inhibition of Steroidogenic Enzymes P450 arom and P450 17

    Gerald A. Wächter;Rolf W. Hartmann;Tom Sergejew;Gertrud L. Grün

  • Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo

    Samer Haidar;Peter B. Ehmer;Stephan Barassin;Christine Batzl-Hartmann

  • In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

    Simon Lucas;Ralf Heim;Christina Ries;Katarzyna E. Schewe

  • Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing.

    Cenbin Lu;Christine K. Maurer;Benjamin Kirsch;Anke Steinbach

  • Synthesis and Evaluation of Novel Steroidal Oxime Inhibitors of P450 17 (17α-Hydroxylase/C17−20-Lyase) and 5α-Reductase Types 1 and 2

    Rolf W. Hartmann;Markus Hector;Samer Haidar;Peter B. Ehmer

  • Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

    Matthias Engel;Valerie Hindie;Valerie Hindie;Laura A Lopez-Garcia;Adriana Stroba

  • Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

    Roman Sommer;Stefanie Wagner;Katharina Rox;Annabelle Varrot

  • Development of a simple and rapid assay for the evaluation of inhibitors of human 17α-hydroxylase-C17,20-lyase (P450cl7) by coexpression of P450cl7 with NADPH-cytochrome-P450-reductase in Escherichia coli

    Peter B. Ehmer;Joachim Jose;Rolf W. Hartmann

  • Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

    Carsten Jagusch;Matthias Negri;Ulrike E Hille;Qingzhong Hu

  • Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

    Sarah Ulmschneider;Ursula Müller-Vieira;Christian D. Klein;Iris Antes

  • New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

    Emmanuel Bey;Sandrine Marchais-Oberwinkler;Matthias Negri;Patricia Kruchten

  • 3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds††PDB code of 2Z with PDK1: 3HRF.

    Adriana Stroba;Francis Schaeffer;Valerie Hindie;Laura Lopez-Garcia

Frequent Co-Authors

Rolf Müller
Rolf Müller Saarland University
Angelo Carotti
Angelo Carotti University of Bari Aldo Moro
Jerzy Adamski
Jerzy Adamski Helmholtz Association of German Research Centres
Claude Cochet
Claude Cochet Grenoble Alpes University
Andrea Cavalli
Andrea Cavalli Italian Institute of Technology
Rita Bernhardt
Rita Bernhardt Saarland University
Alex Odermatt
Alex Odermatt University of Basel
Matthias W. Laschke
Matthias W. Laschke Saarland University
Ronald Gust
Ronald Gust Freie Universität Berlin
Alexandra K. Kiemer
Alexandra K. Kiemer Saarland University

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