Rolf W. Hartmann spends much of his time researching Enzyme, Stereochemistry, Enzyme inhibitor, Chemical synthesis and Biochemistry. The study incorporates disciplines such as In vitro, Estrogen, Aldosterone synthase and In vivo in addition to Enzyme. His Stereochemistry research incorporates themes from Selectivity, IC50, Aromatase and Structure–activity relationship.
His Aromatase research includes themes of Lyase and Pharmacology. His Enzyme inhibitor study which covers Bicyclic molecule that intersects with Ether cleavage, Molecule, Heme and Aldol condensation. His study explores the link between Chemical synthesis and topics such as Docking that cross with problems in Active site.
The scientist’s investigation covers issues in Stereochemistry, Enzyme, Biochemistry, Aromatase and Pharmacology. His Stereochemistry research is multidisciplinary, incorporating perspectives in Biological activity, Selectivity, Steroid, Structure–activity relationship and Enzyme inhibitor. His work in Enzyme inhibitor covers topics such as Chemical synthesis which are related to areas like Docking.
His work is dedicated to discovering how Enzyme, Aldosterone synthase are connected with Aldosterone and other disciplines. His research investigates the connection between Biochemistry and topics such as Pseudomonas aeruginosa that intersect with problems in Pyocyanin. His Pharmacology research is multidisciplinary, incorporating elements of In vivo, Breast cancer and Steroid 11-beta-hydroxylase.
His main research concerns Biochemistry, Stereochemistry, Pharmacology, Pseudomonas aeruginosa and Microbiology. His work on Substituent as part of general Stereochemistry study is frequently connected to Linker, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His Pharmacology study incorporates themes from Aldosterone, Aromatase, Aldosterone synthase, IC50 and Steroid 11-beta-hydroxylase.
Rolf W. Hartmann has researched Pseudomonas aeruginosa in several fields, including Quorum sensing, Virulence factor, Virulence and Cystic fibrosis. The various areas that Rolf W. Hartmann examines in his Microbiology study include Pseudomonas aeruginosa Infections, In vivo and Biofilm. His Enzyme study integrates concerns from other disciplines, such as In vitro and Moiety.
His primary areas of study are Biochemistry, Pseudomonas aeruginosa, Quorum sensing, Stereochemistry and Microbiology. Enzyme, Mutant, IC50, Small molecule and Kinase are among the areas of Biochemistry where Rolf W. Hartmann concentrates his study. His study in the fields of Biosynthesis under the domain of Enzyme overlaps with other disciplines such as Linker.
His Pseudomonas aeruginosa research integrates issues from In vitro, Structure–activity relationship, In vivo and Biofilm. He combines subjects such as Virulence factor and Cell signaling with his study of Quorum sensing. His work carried out in the field of Stereochemistry brings together such families of science as Polymerase, Lead compound, Mode of action, Selectivity and Steroid 11-beta-hydroxylase.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
Sandrine Marchais-Oberwinkler;Claudia Henn;Gabriele Möller;Tobias Klein.
The Journal of Steroid Biochemistry and Molecular Biology (2011)
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
Stefanie Wagner;Roman Sommer;Stefan Hinsberger;Cenbin Lu.
Journal of Medicinal Chemistry (2016)
Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.
Francesco Leonetti;Angelo Favia;Angela Rao;Rosaria Aliano.
Journal of Medicinal Chemistry (2004)
Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.
Noha Nafee;Ayman Husari;Ayman Husari;Christine K. Maurer;Cenbin Lu.
Journal of Controlled Release (2014)
Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
Cenbin Lu;Benjamin Kirsch;Christina Zimmer;Johannes C. de Jong.
Chemistry & Biology (2012)
Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones
Rolf W. Hartmann;Christine Batzl.
Journal of Medicinal Chemistry (1986)
Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo
Samer Haidar;Peter B. Ehmer;Stephan Barassin;Christine Batzl-Hartmann.
The Journal of Steroid Biochemistry and Molecular Biology (2003)
Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)
Emmanuel Bey;Sandrine Marchais-Oberwinkler;Ruth Werth;Matthias Negri.
Journal of Medicinal Chemistry (2008)
Tetrahydronaphthalenes: Influence of Heterocyclic Substituents on Inhibition of Steroidogenic Enzymes P450 arom and P450 17
Gerald A. Wächter;Rolf W. Hartmann;Tom Sergejew;Gertrud L. Grün.
Journal of Medicinal Chemistry (1996)
Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
Rolf Hartmann;Ulrike Hille;Christina Zimmer;Carsten A. Vock.
ACS Medicinal Chemistry Letters (2011)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: