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Laurence G. Rahme

Laurence G. Rahme

D-Index & Metrics

Microbiology

D-Index
65
Citations
25357
World Ranking
2461
National Ranking
995

Overview

Laurence G. Rahme is affiliated with Harvard University in the United States and has contributed extensively to fields including biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields such as molecular biology, pulmonary and respiratory medicine, immunology, genetics, and molecular medicine.

The scientist's work covers various topics, prominently including bacterial biofilms and quorum sensing, antibiotic resistance in bacteria, bacterial genetics and biotechnology, Vibrio bacteria research studies, inhalation and respiratory drug delivery, immune responses and vaccinations, and gut microbiota and health.

Laurence G. Rahme's frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), mBio, eLife, JCI Insight, and Cells. These venues reflect a strong presence in biomedical and molecular biology research forums.

They have authored several recent papers, such as:

  • "Intestinal alkaline phosphatase targets the gut barrier to prevent aging" (2020, JCI Insight)
  • "Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy" (2022, Nature Communications)
  • "Targeting the gut to prevent sepsis from a cutaneous burn" (2020, JCI Insight)
  • "Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis" (2023, mBio)
  • "Characterization of antibiotic resistance profiles in Pseudomonas aeruginosa isolates from burn patients" (2021, Burns)

Laurence G. Rahme collaborates frequently with several co-authors, including Vijay Kumar Singh, Arijit Chakraborty, Marianna Almpani, A. Aria Tzika, and Amy Tsurumi, indicating a diverse network of scientific partnerships.

Best Publications

  • Genomic responses in mouse models poorly mimic human inflammatory diseases

    Seok Junhee Seok;Shaw Warren H. Shaw Warren;G. Cuenca Alex;N. Mindrinos Michael

  • A network-based analysis of systemic inflammation in humans

    Steve E. Calvano;Wenzhong Xiao;Daniel R. Richards;Ramon M. Felciano

  • Common virulence factors for bacterial pathogenicity in plants and animals

    Laurence G. Rahme;Emily J. Stevens;Sean F. Wolfort;Jing Shao

  • A genomic storm in critically injured humans

    Wenzhong Xiao;Wenzhong Xiao;Michael N. Mindrinos;Junhee Seok;Joseph Cuschieri

  • Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.

    Shalina Mahajan-Miklos;Man-Wah Tan;Laurence G. Rahme;Frederick M. Ausubel

  • Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

    Eric Déziel;François Lépine;Sylvain Milot;Jianxin He

  • Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors

    Man-Wah Tan;Laurence G. Rahme;Jeffrey A. Sternberg;Ronald G. Tompkins

  • Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial

    Daniel G Lee;Jonathan M Urbach;Gang Wu;Nicole T Liberati

  • Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

    Georg Jander;Laurence G. Rahme;Frederick M. Ausubel

  • The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.

    Eric Déziel;Suresh Gopalan;Anastasia P. Tampakaki;François Lépine

  • Pseudomonas aeruginosa-Plant Root Interactions. Pathogenicity, Biofilm Formation, and Root Exudation

    Travis S. Walker;Harsh Pal Bais;Eric Déziel;Herbert P. Schweizer

  • Plants and animals share functionally common bacterial virulence factors.

    Laurence G. Rahme;Frederick M. Ausubel;Hui Cao;Eliana Drenkard

  • The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes

    Jianxin He;Regina L. Baldini;Éric Déziel;Maude Saucier

  • A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism

    Hui Cao;Gomathi Krishnan;Boyan Goumnerov;John Tsongalis

  • Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors

    Laurence G. Rahme;Man-Wah Tan;Long Le;Sandy M. Wong

  • MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands

    Gaoping Xiao;Eric Déziel;Eric Déziel;Jianxin He;François Lépine

  • Drosophila melanogaster as a model for human intestinal infection and pathology.

    Yiorgos Apidianakis;Laurence G. Rahme

  • Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa

    François Lépine;Sylvain Milot;Eric Déziel;Jianxin He

  • Plant and environmental sensory signals control the expression of hrp genes in Pseudomonas syringae pv. phaseolicola.

    L G Rahme;M N Mindrinos;N J Panopoulos

  • Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

    Mélissa Starkey;François Lépine;Damien Maura;Arunava Bandyopadhaya

  • Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa.

    Biliana Lesic;Laurence G Rahme

Frequent Co-Authors

Ronald G. Tompkins
Ronald G. Tompkins Harvard University
Michael N. Mindrinos
Michael N. Mindrinos Stanford University
Wenzhong Xiao
Wenzhong Xiao Harvard University
François Lépine
François Lépine Institut National de la Recherche Scientifique
Eric Déziel
Eric Déziel Institut National de la Recherche Scientifique
Frederick M. Ausubel
Frederick M. Ausubel Harvard University
Ronald W. Davis
Ronald W. Davis Stanford University
Henry V. Baker
Henry V. Baker University of Florida
Nicole S. Gibran
Nicole S. Gibran University of Washington
Richard L. Gamelli
Richard L. Gamelli Loyola University Chicago

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