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Microbiology

D-Index
82
Citations
20360
World Ranking
1069
National Ranking
93

Overview

Alain Filloux is affiliated with Imperial College London in the United Kingdom and has contributed extensively to research within the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology, Endocrinology, Molecular Medicine, Genetics, and Ecology. Their work primarily explores bacterial biofilms and quorum sensing, Vibrio bacteria research studies, antibiotic resistance in bacteria, bacterial genetics and biotechnology, Escherichia coli research studies, as well as bacteriophages and microbial interactions and bacterial identification and susceptibility testing.

Recent publications authored or co-authored by Filloux include:

  • Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells, 2021, Nature Microbiology
  • An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs, 2022, Molecular Cell
  • Bacterial protein secretion systems: Game of types, 2022, Microbiology
  • A novel stabilization mechanism for the type VI secretion system sheath, 2021, Proceedings of the National Academy of Sciences
  • Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting, 2022, Frontiers in Microbiology

Filloux has collaborated frequently with several co-authors, including Despoina A. I. Mavridou, R. Christopher D. Furniss, Tiago R. D. Costa, Kira Eilers, and Laura M. Nolan, reflecting a diverse network of research partnerships.

Major venues for their published work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Microbiology
  • Microbiology
  • PLoS Pathogens
  • Microbiology Spectrum

In addition to articles, Filloux has contributed to academic literature through book publications such as "Pseudomonas aeruginosa," published by Springer Nature in 2022.

The research of Filloux covers multiple critical topics within microbiology and molecular biology, including mechanisms of bacterial secretion systems, quorum sensing, bacterial toxins, and interactions within microbial communities. This body of work contributes to understanding the behavior and pathogenicity of bacteria as well as potential therapeutic interventions influenced by microbial communication pathways.

Best Publications

  • Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria.

    Martina Valentini;Alain Filloux

  • Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

    Laura K. Jennings;Kelly M. Storek;Hannah E. Ledvina;Charlène Coulon

  • Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes

    Isabelle Ventre;Andrew L. Goodman;Isabelle Vallet-Gely;Perrine Vasseur

  • The bacterial type VI secretion machine: yet another player for protein transport across membranes.

    Alain Filloux;Alain Filloux;Abderrahman Hachani;Abderrahman Hachani;Sophie Bleves

  • Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening

    C. Leopold Kurz;Sophie Chauvet;Emmanuel Andres;Marianne Aurouze

  • Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons.

    Sophie Bleves;Véronique Viarre;Richard Salacha;Gérard P.F. Michel

  • The chaperone/usher pathways of Pseudomonas aeruginosa: Identification of fimbrial gene clusters (cup) and their involvement in biofilm formation

    Isabelle Vallet;John W. Olson;Stephen Lory;Andrée Lazdunski

  • Involvement of the twin-arginine translocation system in protein secretion via the type II pathway.

    Romé Voulhoux;Geneviève Ball;Bérengère Ize;Michael L. Vasil

  • Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen

    Andrew L. Goodman;Massimo Merighi;Mamoru Hyodo;Isabelle Ventre

  • A novel two‐component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes

    Hemantha D. Kulasekara;Isabelle Ventre;Bridget R. Kulasekara;Andrée Lazdunski

  • The underlying mechanisms of type II protein secretion

    Alain Filloux

  • Agrobacterium tumefaciens deploys a superfamily of type VI secretion DNase effectors as weapons for interbacterial competition in planta

    Lay-Sun Ma;Abderrahman Hachani;Jer-Sheng Lin;Alain Filloux

  • The pel genes of the Pseudomonas aeruginosa PAK strain are involved at early and late stages of biofilm formation.

    Perrine Vasseur;Isabelle Vallet-Gely;Chantal Soscia;Stéphane Genin

  • The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c‐di‐GMP signalling

    Joana A. Moscoso;Helga Mikkelsen;Stephan Heeb;Paul Williams

  • Type VI secretion and anti-host effectors

    Abderrahman Hachani;Thomas E Wood;Alain Filloux

  • Key two‐component regulatory systems that control biofilm formation in Pseudomonas aeruginosa

    Helga Mikkelsen;Melissa Sivaneson;Alain Filloux

  • The Pseudomonas putida T6SS is a plant warden against phytopathogens

    Patricia Bernal;Luke P Allsopp;Alain Filloux;María A Llamas

  • Protein Secretion Systems in Pseudomonas aeruginosa: An Essay on Diversity, Evolution, and Function

    Alain Filloux

  • Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase

    Marc Bally;Alain Filloux;Mohammed Akrim;Geneviéve Ball

  • The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells

    Thibault G. Sana;Abderrahman Hachani;Iwona Bucior;Chantal Soscia

  • GSP-dependent protein secretion in Gram-negative bacteria: the Xcp system of Pseudomonas aeruginosa

    Alain Filloux;Gérard Michel;Marc Bally

Frequent Co-Authors

Andrée Lazdunski
Andrée Lazdunski Centre national de la recherche scientifique, CNRS
Jan Tommassen
Jan Tommassen Utrecht University
Paul S. Freemont
Paul S. Freemont Imperial College London
Laurent Dortet
Laurent Dortet University of Paris-Saclay
Rémy A. Bonnin
Rémy A. Bonnin University of Paris-Saclay
Stephen Lory
Stephen Lory Harvard University
Julian Parkhill
Julian Parkhill University of Cambridge
Serge Mostowy
Serge Mostowy London School of Hygiene & Tropical Medicine
Andrew Bush
Andrew Bush Imperial College London
Thierry Naas
Thierry Naas University of Paris-Saclay

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